Gene: Adar

Order

Name adenosine deaminase, RNA-specific

Synonyms
  • ADAR1
  • mZaADAR
  • Adar1p150
  • Adar1p110

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1889575    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Adar

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Adar data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Adartm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.0
abnormal neural tube closure Adartm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.0
abnormal placenta size Adartm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.0
pale yolk sac Adartm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.0
pallor Adartm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.0
preweaning lethality, complete penetrance Adartm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Adartm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
abnormal bone structure Adartm1b(EUCOMM)Wtsi HET Female postnatal 2.0E-6
decreased body length Adartm1b(EUCOMM)Wtsi HET Female postnatal 2.04E-5
decreased bone mineral content Adartm1b(EUCOMM)Wtsi HET Female postnatal 2.3E-5
increased circulating HDL cholesterol level Adartm1b(EUCOMM)Wtsi HET Male postnatal 6.6E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Adrenal gland 2 No (5/393) (2/2)
Aorta 4 No (1/562) (2/4)
Blood vessel 2 No
Bone 4 No (1/539) (4/4)
Brain 4 No (6/562) (4/4)
Brainstem 4 No (4/562) (2/4)
Brown adipose tissue 2 No
Brown adipose tissue 2 No
Cartilage tissue 4 No (1/562) (3/4)
Cerebellum 4 No (4/562) (1/4)
Cerebral cortex 4 No (5/562) (2/4)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 4 No (1/562) (2/4)
Gall bladder 2 No (1/2)
Heart 4 No (3/562) (4/4)
Hippocampus 4 No (5/562) (2/4)
Hypothalamus 4 No (4/562) (2/4)
Kidney 4 No (20/562) (4/4)
Large intestine 4 No (12/562) (4/4)
Liver 4 No (2/4)
Lower urinary tract 4 No (3/562) (2/4)
Lung 4 No (3/562) (4/4)
Lymph node 4 No (1/562) (1/4)
Mammary gland 4 No (1/4)
Midbrain 2 No (2/2)
Esophagus 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Olfactory lobe 2 No
Ovary 4 No (1/562) (1/4)
Oviduct 4 No (2/562) (1/4)
Pancreas 4 No (6/562) (2/4)
Parathyroid gland 2 No (2/540) (1/2)
Peripheral nervous system 4 No (3/562) (4/4)
Peyer's patch 2 No
Peyer's patch 2 No (1/393) (1/2)
Pituitary gland 4 No (1/562) (2/4)
Prostate gland 4 No (5/562)
Skeletal muscle 2 No
Skeletal muscle tissue 2 No
Skin 4 No (1/562) (2/4)
Small intestine 4 No (11/562) (4/4)
Spinal cord 4 No (3/562) (4/4)
Spleen 4 No (4/562) (4/4)
Stomach 4 No (9/562) (4/4)
Striatum 4 No (4/562) (1/4)
Submandibular gland 2 No (1/104) (2/2)
Testis 4 No (4/562) (2/4)
Thalamus 2 No (2/2)
Thymus 4 No (4/4)
Thyroid gland 4 No (16/562) (3/4)
Trachea 4 No (3/562) (4/4)
Urinary bladder 2 No (2/2)
Uterus 4 No (2/562) (2/4)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/3)
Dorsal root ganglion 1 (1/45) (1/2)
Ear 2 (1/482) Image Only
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (2/3)
Foot 2 (1/482) (1/3)
Forebrain 2 (1/482) (1/3)
Forelimb 2 (1/482) (2/3)
Fronto-nasal process 1 (1/46) Image Only
Hand 2 (1/482) (1/3)
Head 2 (5/482) (2/3)
Heart 2 (1/482) (2/3)
Hindbrain 2 (6/482) (2/3)
Hindlimb 2 (1/482) (2/3)
Liver 2 (1/482)
Lung 2 (1/482) Image Only
Mandibular process 2 (1/482) (2/3)
Maxillary process 2 (1/482) (2/3)
Midbrain 2 (1/482) (2/3)
Nose 1 (1/47) (1/2)
Oral cavity 2 (1/482) (1/3)
Skin 2 (1/482) (2/3)
Spinal cord 2 (1/46) (2/3)
Tail 2 (1/482) (2/3)
Tail somite 2 (1/482) Image Only


Secondary lacZ Expression Data
postnatal mouse (18)
  • Adartm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    stomach, oesophagus, HET, Female, WTSI

show all 18 images

trunk (13)
  • Adartm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    stomach, oesophagus, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI

show all 13 images

digestive system (4)
  • Adartm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    stomach, oesophagus, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    small intestine, HET, Female, WTSI
immune system (3)
  • Adartm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
nervous system (3)
  • Adartm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    peripheral nervous system, pituitary gland, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
endocrine system (2)
  • Adartm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Male, WTSI
respiratory system (2)
  • Adartm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Male, WTSI
urinary system (2)
  • Adartm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    lower urinary tract, HET, Female, WTSI
cardiovascular system (1)
  • Adartm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
reproductive system (1)
  • Adartm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
set of connective tissues (1)
  • Adartm1a(EUCOMM)Wtsi
    cartilage tissue, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Skull Lateral Orientation
    11 Images
  • Combined SHIRPA and Dysmorphology
    2 Images
  • Electroretinography: Cone waveform (pdf format)
    4 Images
  • Electroretinography: Rod waveform (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
Legacy Phenotype Associated Images
Xray (48)
  • Adartm1a(EUCOMM)Wtsi
    HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    head, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    head, HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    HET, Male, WTSI
  • Adartm1a(EUCOMM)Wtsi
    body, HET, Female, WTSI

show all 48 images

Skin Histopathology (3)
  • Adartm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Adartm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
Eye Morphology (1)
  • Adartm1a(EUCOMM)Wtsi
    eye, cataracts, HET, Male, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Adartm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Adartm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene