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Gene: Ubr3 MGI:1861100

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
ubiquitin protein ligase E3 component n-recognin 3
Synonyms:
4833421P10Rik,  1110059H15Rik,  A130030D10Rik,  Zfp650

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ubr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ubr3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Body Mass Index Quantitative Trait Locus 19
Anosmia, Hyperinsulinemia, Obesity, Increased serum leptin, Hyposmia, Polyphagia OMIM:617885
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Diabetes mellitus, Hypogonadotropic hypogonadism, Anosmia, Obesity, Absence of pubertal developme... OMIM:610628
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Hypogonadotropic hypogonadism, Anosmia, Decreased circulating luteinizing hormone level, Decrease... OMIM:614842
Thumb Agenesis, Short Stature, And Immunodeficiency
Anosmia, Delayed puberty OMIM:274190
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Hypogonadotropic hypogonadism, Anosmia, Decreased circulating luteinizing hormone level, Decrease... OMIM:614839
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
Anosmia, Hypogonadism, Delayed puberty OMIM:615270
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Reduced response to gonadotropin-releasing hormone stimulation test, Anosmia, Decreased circulati... OMIM:616030
Hypogonadotropic Hypogonadism 25 With Anosmia
Hypothalamic gonadotropin-releasing hormone deficiency, Anosmia, Hypoplasia of the ovary, Decreas... OMIM:618841
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Anosmia, Decreased circulating luteinizing hormone level, Decreased circulating follicle stimulat... OMIM:614897
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia
Anosmia, Hypogonadism, Absence of pubertal development OMIM:615267
Anosmia For Butyl Mercaptan
Anosmia OMIM:270350
Isovaleric Acid, Inability To Smell
Anosmia OMIM:243450
Anosmia, Isolated Congenital, X-Linked
Anosmia OMIM:301700
Anosmia, Isolated Congenital
Anosmia OMIM:107200
Anosmia For Isobutyric Acid
Partial anosmia OMIM:207000
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Anosmia, Hypogonadotropic hypogonadism OMIM:614858
Musk, Inability To Smell
Anosmia OMIM:254150
Kallmann Syndrome With Spastic Paraplegia
Hypothalamic gonadotropin-releasing hormone deficiency, Eunuchoid habitus, Hypogonadotropic hypog... OMIM:308750
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypogonadotropic hypogonadism, Anosmia, Decreased circulating gonadotropin concentration, Hypopla... OMIM:614841
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Hypothalamic gonadotropin-releasing hormone deficiency, Eunuchoid habitus, Hypogonadotropic hypog... OMIM:308700
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Hypogonadotropic hypogonadism, Anosmia, Small pituitary gland, Delayed puberty, Hyposmia OMIM:612702
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Hyposmia, Anosmia, Hypogonadotropic hypogonadism, Bifid nose OMIM:614838
Hypogonadotropic Hypogonadism 17 With Or Without Anosmia
Hyposmia, Hypogonadotropic hypogonadism OMIM:615266
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Anosmia, Hypogonadotropic hypogonadism OMIM:612370
Chondrodysplasia Punctata 1, X-Linked Recessive
Depressed nasal bridge, Anosmia, Hypogonadism, Short nose, Short nasal septum OMIM:302950
Leber Congenital Amaurosis 10
Hyposmia OMIM:611755
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Hyposmia, Delayed puberty OMIM:615271
Apnea, Obstructive Sleep
Anosmia OMIM:107650
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Hypogonadotropic hypogonadism, Anosmia, Absence of pubertal development, Decreased circulating lu... OMIM:614837
Huntington Disease
Oral-pharyngeal dysphagia, Aggressive behavior, Weight loss, Abnormality of the sense of smell, A... ORPHA:399
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Hyposmia, Anosmia, Hypogonadotropic hypogonadism OMIM:244200
Bardet-Biedl Syndrome 17
Anosmia, Obesity, Hypogonadism, Hyposmia, Polydipsia OMIM:615994
Isolated Follicle Stimulating Hormone Deficiency
Decreased serum testosterone concentration, Hypogonadotropic hypogonadism, Female hypogonadism, G... ORPHA:52901
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Hypogonadotropic hypogonadism, Choanal atresia, Anosmia, Delayed puberty, Hyposmia OMIM:147950
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Anosmia, Small pituitary gland OMIM:614880
Peroxisome Biogenesis Disorder 9B
Anosmia, Total anosmia OMIM:614879
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Agitatio... ORPHA:33543
Septo-Optic Dysplasia Spectrum
Anterior pituitary hypoplasia, Maternal diabetes, Anosmia, Obesity, Polydipsia, Abnormality of th... ORPHA:3157
Johnson Neuroectodermal Syndrome
Choanal atresia, Bulbous nose, Anosmia, Hypogonadism, Failure to thrive ORPHA:2316
Hyperostosis Cranialis Interna
Hyposmia, Anosmia OMIM:144755
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Hypogonadotropic hypogonadism, Abnormality of the sense of smell OMIM:146110
Solitary Median Maxillary Central Incisor
Abnormal nasopharynx morphology, Midnasal stenosis, Choanal atresia, Decreased response to growth... OMIM:147250
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Aplasia/Hypoplasia involving the nose, Hypogonadotropic hypogonadism, Choanal atresia, Abnormalit... ORPHA:1135
Kufor-Rakeb Syndrome
Hyposmia, Anosmia, Dysphagia, Aggressive behavior OMIM:606693
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Abnormal nostril morphology, Anosmia, Hypogonadotropic hypogonadism, Short nose ORPHA:1295
Blepharophimosis With Ptosis, Syndactyly, And Short Stature
Anosmia, Wide nasal bridge OMIM:210745
Blepharophimosis-Ptosis-Esotropia-Syndactyly-Short Stature Syndrome
Anosmia ORPHA:2057
Indifference To Pain, Congenital, Autosomal Recessive
Hyposmia, Anosmia OMIM:243000
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Hypogonadotropic hypogonadism, Decreased circulating dihydrotestosterone concentration, Decreased... OMIM:228300
Leukoencephalopathy With Dystonia And Motor Neuropathy
Hyposmia, Hypergonadotropic hypogonadism OMIM:613724
Aural Atresia, Congenital
Hyposmia OMIM:607842
Bardet-Biedl Syndrome 19
Hyposmia, Hypogonadism, Obesity OMIM:615996
Kallmann Syndrome
Hypothalamic gonadotropin-releasing hormone deficiency, Hypogonadotropic hypogonadism, Anosmia, O... ORPHA:478
Polyendocrine-Polyneuropathy Syndrome
Hypogonadotropic hypogonadism, Anterior pituitary hypoplasia, Central hypothyroidism, Abnormality... OMIM:616113
Refsum Disease, Classic
Anosmia OMIM:266500
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Anosmia OMIM:601152
Refsum Disease
Anosmia ORPHA:773
Ciliary Dyskinesia, Primary, 1
Nasal polyposis, Anosmia, Chronic rhinitis OMIM:244400
Holoprosencephaly
Aplasia/Hypoplasia involving the nose, Diabetes mellitus, Anteverted nares, Choanal atresia, Fail... ORPHA:2162
Kallmann Syndrome-Heart Disease Syndrome
Total anosmia, Hypogonadotropic hypogonadism, Partial anosmia, Delayed puberty ORPHA:2326
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anosmia, Single naris, Absent nares, Hypogonadism, Hyposmia ORPHA:2250
8P11.2 Deletion Syndrome
Depressed nasal bridge, Hypogonadotropic hypogonadism, Anosmia, Hypogonadism, Abnormality of the ... ORPHA:251066
Gorlin Syndrome
Hypogonadotropic hypogonadism, Wide nasal bridge, Abnormality of the sense of smell ORPHA:377
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, Glomus tympan... OMIM:168000
Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Anosmia, Hypogonadotropic hypogonadism, Delayed puberty OMIM:619718
Pheochromocytoma/Paraganglioma Syndrome 3
Extraadrenal pheochromocytoma, Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Para... OMIM:605373
Waardenburg Syndrome, Type 4C
Anosmia, Hypogonadism OMIM:613266
Ventricular Extrasystoles With Syncopal Episodes-Perodactyly-Robin Sequence Syndrome
Abnormality of the sense of smell ORPHA:3201
Hereditary Late-Onset Parkinson Disease
Impulsivity, Weight loss, Agitation, Dysphagia, Hyposmia ORPHA:411602
Marcus-Gunn Syndrome
Choanal atresia, Abnormality of the sense of smell ORPHA:91412
Superficial Siderosis
Anosmia, Partial anosmia ORPHA:247245
Waardenburg Syndrome, Type 2E
Anosmia OMIM:611584
Young-Onset Parkinson Disease
Hyposmia, Restless legs, Agitation, Impulsivity ORPHA:2828
Bosma Arhinia Microphthalmia Syndrome
Anosmia, Hypogonadotropic hypogonadism, Aplasia of the nose, Choanal atresia OMIM:603457
Meningioma
Enlarged pituitary gland, Decreased circulating cortisol level, Hypogonadotropic hypogonadism, Re... ORPHA:2495
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Anosmia OMIM:609136
Charge Syndrome
Hypogonadotropic hypogonadism, Choanal atresia, Depressed nasal bridge, Anosmia, Abnormality of t... ORPHA:138
Hydrolethalus
Abnormality of the sense of smell ORPHA:2189
Parkinson Disease 8, Autosomal Dominant
Hyposmia OMIM:607060
8Q21.11 Microdeletion Syndrome
Wide nose, Underdeveloped nasal alae, Abnormality of the sense of smell ORPHA:284160
Moebius Syndrome
Hypogonadotropic hypogonadism, Dysphagia, Abnormality of the sense of smell ORPHA:570
Neuropathy, Hereditary Sensory And Autonomic, Type Viii
Hyposmia OMIM:616488
Acro-Renal-Mandibular Syndrome
Abnormality of the sense of smell ORPHA:958
Charge Syndrome
Hypoparathyroidism, Hypogonadotropic hypogonadism, Decreased response to growth hormone stimulati... OMIM:214800
Lacrimoauriculodentodigital Syndrome
Anosmia, Choanal atresia, Dysphagia ORPHA:2363
Campomelic Dysplasia
Depressed nasal bridge, Abnormality of the sense of smell ORPHA:140
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Hyposmia, Abnormal repetitive mannerisms, Obesity OMIM:618653
Wilson Disease
Hypoparathyroidism, Hyposmia, Dysphagia OMIM:277900
Amoebiasis Due To Free-Living Amoebae
Hyposmia, Restlessness, Abnormality of the adrenal glands ORPHA:68
Occipital Horn Syndrome
Dysphagia, Abnormality of the sense of smell ORPHA:198
Leopard Syndrome 1
Depressed nasal ridge, Hypoplasia of the ovary, Delayed puberty, Hyposmia, Delayed menarche OMIM:151100
Von Hippel-Lindau Disease
Pancreatic islet cell adenoma, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paragangliom... ORPHA:892

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ubr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ubr3.

No publications found that use IMPC mice or data for Ubr3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ubr3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Ubr3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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