Gene: Rnf10

Order

Name ring finger protein 10

Status ES CellsMice
em1
Mice
em1
Mice
tm1b
Mice
tm1a
Mice
em1
phenotype data available

Links MGI:1859162    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Rnf10

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rnf10 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal kidney morphology Rnf10em1(IMPC)Mbp HOM Male postnatal 0.0
enlarged heart Rnf10tm1b(KOMP)Wtsi HET Male postnatal 0.0
preweaning lethality, incomplete penetrance Rnf10tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.77E-14
abnormal behavior Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 7.69E-13
hyperactivity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.44E-12
abnormal sleep behavior Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.08E-10
abnormal lens morphology Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 4.23E-10
decreased total retina thickness Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.65E-9
decreased grip strength Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.35E-9
decreased startle reflex Rnf10em1(IMPC)J HOM Female Male postnatal 2.94E-9
decreased circulating HDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.69E-9
decreased circulating cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.88E-9
decreased body length Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 5.24E-9
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 7.59E-9
cataract Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 8.09E-9
decreased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 3.04E-8
increased circulating sodium level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.71E-7
decreased circulating glucose level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 4.51E-7
decreased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 5.39E-7
increased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Female postnatal 5.39E-7
increased fluid intake Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 7.83E-7
abnormal behavioral response to light Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 7.92E-7
decreased circulating alkaline phosphatase level Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 8.19E-7
increased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.0E-7
increased bone mineral content Rnf10em1(IMPC)J HOM Female postnatal 1.14E-6
thin ventricular wall Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.3E-6
increased vertical activity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.56E-6
increased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.6E-6
limb grasping Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 2.06E-6
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 2.5E-6
decreased circulating total protein level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.51E-6
increased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.69E-6
decreased bone mineral density Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.7E-6
hypoactivity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.94E-6
increased heart weight Rnf10tm1b(KOMP)Wtsi HET Male postnatal 4.07E-6
decreased hemoglobin content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 8.8E-6
abnormal bone structure Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.17E-5
decreased prepulse inhibition Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 1.17E-5
decreased cornea thickness Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 1.26E-5
decreased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 1.79E-5
increased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Female postnatal 1.79E-5
abnormal tibia morphology Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 1.99E-5
improved glucose tolerance Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.07E-5
decreased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.07E-5
increased KLRG1-positive NK cell number Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.26E-5
increased NK cell number Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.58E-5
decreased mean corpuscular hemoglobin concentration Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 2.73E-5
increased red blood cell distribution width Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.14E-5
convulsive seizures Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 4.05E-5
decreased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 5.14E-5
decreased circulating bilirubin level Rnf10tm1a(KOMP)Wtsi HOM Female Male postnatal 5.26E-5
increased circulating triglyceride level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 5.34E-5
decreased vertical activity Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 5.88E-5
increased cardiac muscle contractility Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 7.32E-5
abnormal bone structure Rnf10em1(IMPC)J HOM Female postnatal 7.4E-5
increased circulating chloride level Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 7.63E-5
limb grasping Rnf10em1(IMPC)J HOM Female postnatal 8.6E-5
decreased circulating LDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 8.62E-5
increased or absent threshold for auditory brainstem response Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.41E-5
increased erythrocyte cell number Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 9.8E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (4/4)
Adrenal gland 14 Yes (5/393) (11/16)
Aorta 18 Yes (1/562) (13/20)
Blood 2 No
Blood vessel 4 No (4/4)
Bone 14 Yes (1/539) (2/16)
Bone marrow 2 No
Brain 18 Yes (6/562) (19/20)
Brainstem 18 No (4/562) (15/20)
Brown adipose tissue 4 No (2/4)
Brown adipose tissue 14 Yes (13/16)
Cartilage tissue 18 No (1/562) (11/20)
Cecum 8 Yes (1/355) (6/10)
Cerebellum 18 No (4/562) (15/20)
Cerebral cortex 18 No (5/562) (15/20)
Chest bone 6 Yes (8/8)
Colon 6 No (1/99) (6/8)
Cranium 6 No
Diaphragm 6 Yes (6/8)
Duodenum 4 Yes (1/99) (6/6)
Epididymis 8 Yes (4/106) (1/10)
Esophagus 14 Yes (2/393) (13/16)
Eye 18 Yes (1/562) (3/20)
Gall bladder 14 Yes (9/16)
Gonadal fat pad 4 Yes (6/6)
Harderian gland 6 Yes (6/8)
Heart 18 Yes (3/562) (19/20)
Hindlimb 6 Yes (6/8)
Hippocampus 18 No (5/562) (15/20)
Hypothalamus 18 No (4/562) (15/20)
Ileum 4 Yes (1/99) (6/6)
Jejunum 4 Yes (1/99) (6/6)
Kidney 18 Yes (20/562) (19/20)
Large intestine 18 Yes (12/562) (17/20)
Liver 18 Yes (10/20)
Lower urinary tract 18 No (3/562) (15/20)
Lung 18 Yes (3/562) (14/20)
Lymph node 18 Yes (1/562)
Main olfactory bulb 6 Yes (6/8)
Mammary gland 18 Yes (3/20)
Mesenteric lymph node 6 Yes
Mesenteric adipose tissue 4 Yes (6/6)
Midbrain 6 No (7/8)
Esophagus 4 No (4/4)
Olfactory lobe 14 No (4/393) (13/16)
Olfactory lobe 4 No (2/4)
Oral epithelium 10 No
Ovary 18 Yes (1/562) (8/20)
Oviduct 18 Yes (2/562) (8/20)
Pancreas 18 Yes (6/562) (9/20)
Parathyroid gland 14 Yes (2/540) (14/16)
Parotid gland 6 Yes
Penis 6 Yes (4/8)
Peripheral nervous system 18 No (3/562) (15/20)
Peyer's patch 4 No
Peyer's patch 14 No (1/393)
Pituitary gland 18 Yes (1/562) (13/20)
Prostate gland 18 Yes (5/562) (7/20)
Quadriceps 4 Yes (6/6)
Sciatic nerve 6 Yes (4/8)
Skeletal muscle 14 No (15/16)
Skeletal muscle tissue 4 No (4/4)
Skin 18 Yes (1/562) (14/20)
Small intestine 18 No (11/562) (15/20)
Spinal cord 18 Yes (3/562) (18/20)
Spleen 18 Yes (4/562) (9/20)
Stomach 18 Yes (9/562) (13/20)
Stomach pyloric region 6 No
Striatum 18 No (4/562) (15/20)
Sublingual gland 6 Yes
Submandibular gland 8 Yes (1/104) (3/10)
Testis 18 Yes (4/562) (10/20)
Thalamus 6 No (7/8)
Thymus 18 Yes (1/20)
Thyroid gland 18 Yes (16/562) (5/20)
Tongue 6 Yes (6/8)
Trachea 18 Yes (3/562) (17/20)
Trigeminal V nerve 8 Yes (8/10)
Urinary bladder 8 Yes (7/10)
Uterus 18 Yes (2/562) (8/20)
Vagina 6 Yes (3/8)
Vas deferens 8 No (1/360)
Vascular system 14 No (1/393) (9/16)
Vesicular gland 8 Yes (1/10)
White adipose tissue 18 Yes (6/20)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(17)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/45)
Axial skeleton 2 (1/47)
Brain 9 (6/482) (8/12)
Central nervous system ganglion 2 (1/47)
Dorsal root ganglion 3 (1/45)
Ear 9 (1/482) (7/12)
Embryo 9 (1/482) (11/12)
Outer ear 2 (1/45) (2/2)
Eye 9 (1/482) (10/12)
Foot 9 (1/482) (4/12)
Forearm 5 (1/280) (5/5)
Forebrain 9 (1/482) (8/12)
Forelimb 9 (1/482) (11/12)
Fronto-nasal process 3 (1/46) (2/3)
Gut 2 (1/46) (2/2)
Hand 9 (1/482) (4/12)
Head 9 (5/482) (9/12)
Head mesenchyme 2 (1/45)
Heart 9 (1/482) (4/12)
Heart ventricle 2 (1/45)
Hindbrain 9 (6/482) (8/12)
Hindlimb 9 (1/482) (11/12)
Intestine 2 (1/45) (2/2)
Liver 9 (1/482) (2/12)
Lower leg 5 (1/280) (5/5)
Lung 9 (1/482) (2/12)
Mandibular process 9 (1/482) (8/12)
Maxillary process 9 (1/482) (8/12)
Meckel's cartilage 2
Midbrain 9 (1/482) (7/12)
Nasal septum 2 (1/45)
Nose 3 (1/47) (3/3)
Notochord 2 (1/45) (2/2)
Oral cavity 9 (1/482) (3/12)
Outflow tract 2 (1/45)
Pericardium 1 (1/44)
Pharynx 2 (1/44) (2/2)
2 (11/27)
Radius-ulna pre-cartilage condensation 2 (1/44) (2/2)
Rib pre-cartilage condensation 2 (1/44)
Skeleton 2 (1/47)
Skin 9 (1/482) (4/12)
Spinal cord 3 (1/46) (1/3)
Tail 9 (1/482) (11/12)
Tail somite 9 (1/482) (8/12)
Thoracic vertebral cartilage condensation 2 (1/44)
Tongue 2 (1/44)
Trachea 1 (1/46)
Trunk mesenchyme 2 (1/45)
Upper arm 5 (1/280) (3/5)
Upper leg 5 (1/280) (3/5)
Vibrissa 2 (1/45) (2/2)
  • alimentary system(2)
    Mandibular process ambiguous
    Maxillary process ambiguous
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb


Secondary lacZ Expression Data
trunk (29)
  • Rnf10tm1a(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    ESOPHAGUS, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    TRACHEA, PARATHYROID GLAND, THYROID GLAND, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    ADRENAL GLAND, HET, Male, WTSI

show all 29 images

digestive system (9)
  • Rnf10tm1a(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    ESOPHAGUS, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    GALL BLADDER, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    GALL BLADDER, HET, Male, WTSI

show all 9 images

nervous system (7)
  • Rnf10tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, PITUITARY GLAND, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HYPOTHALAMUS, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Male, WTSI

show all 7 images

reproductive system (5)
  • Rnf10tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    UTERUS, OVARY, OVIDUCT, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    PROSTATE GLAND, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    OVARY, HET, Female, WTSI
cardiovascular system (4)
  • Rnf10tm1a(KOMP)Wtsi
    HEART, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    BLOOD VESSEL, SPLEEN, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    AORTA, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    BLOOD VESSEL, HET, Female, WTSI
endocrine system (4)
  • Rnf10tm1a(KOMP)Wtsi
    TRACHEA, PARATHYROID GLAND, THYROID GLAND, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    PARATHYROID GLAND, HET, Female, WTSI
urinary system (4)
  • Rnf10tm1a(KOMP)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    LOWER URINARY TRACT, HET, Male, WTSI
immune system (3)
  • Rnf10tm1a(KOMP)Wtsi
    MESENTERIC LYMPH NODE, LYMPH NODE, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    BLOOD VESSEL, SPLEEN, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    THYMUS, HET, Female, WTSI
respiratory system (3)
  • Rnf10tm1a(KOMP)Wtsi
    TRACHEA, PARATHYROID GLAND, THYROID GLAND, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    LUNG, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    LUNG, HET, Female, WTSI
integumental system (2)
  • Rnf10tm1a(KOMP)Wtsi
    SKIN, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    SKIN, HET, Female, WTSI
adipose tissue (1)
  • Rnf10tm1a(KOMP)Wtsi
    BROWN ADIPOSE TISSUE, HET, Female, WTSI
exocrine system (1)
  • Rnf10tm1b(KOMP)Wtsi
    PROSTATE GLAND, HET, Male, WTSI
musculoskeletal system (1)
  • Rnf10tm1a(KOMP)Wtsi
    BONE, HET, Female, WTSI
sensory organ (1)
  • Rnf10tm1a(KOMP)Wtsi
    EYE, HET, Female, WTSI
set of connective tissues (1)
  • Rnf10tm1a(KOMP)Wtsi
    BROWN ADIPOSE TISSUE, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    89 Images
  • X-ray: XRay Images Dorso Ventral
    190 Images
  • X-ray: XRay Images Lateral Orientation
    164 Images
  • X-ray: XRay Images Forepaw
    61 Images
  • X-ray: XRay Images Hind Leg and Hip
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    73 Images
  • Adult LacZ: LacZ Images Wholemount
    505 Images
  • Gross Pathology and Tissue Collection
    14 Images
  • Eye Morphology: Images Ophthalmoscopy
    9 Images
  • Embryo LacZ: LacZ images wholemount
    87 Images
Legacy Phenotype Associated Images
Xray (155)
  • Rnf10tm1a(KOMP)Wtsi
    TRUNK, HOM, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    TRUNK, HOM, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    HEAD, HOM, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    HEAD, HOM, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    TRUNK, HOM, Female, WTSI

show all 155 images

Brain Histopathology (9)
  • Rnf10tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    CORPUS CALLOSUM, decreased corpus callosum size, HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    ANTERIOR COMMISSURE, decreased anterior commissure size, HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    INTERNAL CAPSULE, decreased brain internal capsule size, HOM, Male, WTSI

show all 9 images

Histology Slide (4)
  • Rnf10tm1b(KOMP)Wtsi
    HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HET, Female, WTSI
Skin Histopathology (1)
  • Rnf10tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rnf10em1(IMPC)Mbp Indel causing a Frameshift Mutation
Vector
Gene
Rnf10em1(IMPC)J Exon Deletion
Vector
Gene
Rnf10tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Rnf10tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rnf10em1(IMPC)Bay Exon Deletion
Vector
Gene
Rnf10tm303169(L1L2_Bact_P)
Vector
Gene