Gene: Rnf10

Order

Name ring finger protein 10

Status ES CellsMice
em1
Mice
em1
Mice
tm1a
Mice
tm1b
Mice
em1
phenotype data available

Links MGI:1859162    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Rnf10

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rnf10 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Liver - glycogen deposition Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 0.0
abnormal kidney morphology Rnf10em1(IMPC)Mbp HOM Male postnatal 0.0
abnormal spleen morphology Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 0.0
enlarged heart Rnf10tm1b(KOMP)Wtsi HET Male postnatal 0.0
preweaning lethality, incomplete penetrance Rnf10tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.77E-14
abnormal behavior Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.67E-13
decreased startle reflex Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 6.48E-13
hyperactivity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.09E-12
abnormal sleep behavior Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.07E-10
abnormal lens morphology Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 4.01E-10
decreased total retina thickness Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.65E-9
decreased grip strength Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.35E-9
decreased startle reflex Rnf10em1(IMPC)J HOM Female Male postnatal 3.04E-9
decreased circulating HDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.69E-9
decreased circulating cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.88E-9
decreased body length Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 5.21E-9
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 6.92E-9
cataract Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 7.66E-9
decreased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 3.04E-8
increased circulating sodium level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.71E-7
decreased circulating glucose level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 4.94E-7
increased fluid intake Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 5.76E-7
decreased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 6.36E-7
increased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Female postnatal 6.36E-7
increased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.0E-7
abnormal behavioral response to light Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.95E-7
decreased circulating alkaline phosphatase level Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 1.27E-6
thin ventricular wall Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.3E-6
increased vertical activity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.52E-6
increased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.6E-6
limb grasping Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 1.9E-6
increased bone mineral content Rnf10em1(IMPC)J HOM Female postnatal 2.09E-6
hypoactivity Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.36E-6
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 2.5E-6
decreased circulating total protein level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.51E-6
increased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.69E-6
decreased bone mineral density Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.76E-6
increased heart weight Rnf10tm1b(KOMP)Wtsi HET Male postnatal 4.06E-6
decreased lean body mass Rnf10em1(IMPC)Bay HOM Female Male postnatal 4.66E-6
abnormal retinal blood vessel morphology Rnf10em1(IMPC)Bay HOM Female postnatal 8.46E-6
decreased hemoglobin content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 8.8E-6
abnormal bone structure Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 1.17E-5
decreased prepulse inhibition Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 1.17E-5
increased heart left ventricle size Rnf10em1(IMPC)Bay HOM Female Male postnatal 1.23E-5
decreased cornea thickness Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 1.26E-5
decreased startle reflex Rnf10em1(IMPC)Bay HOM Male postnatal 1.66E-5
decreased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 1.94E-5
increased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Female postnatal 1.94E-5
abnormal tibia morphology Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 1.98E-5
decreased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.06E-5
improved glucose tolerance Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.07E-5
increased KLRG1-positive NK cell number Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.42E-5
increased NK cell number Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 2.58E-5
decreased mean corpuscular hemoglobin concentration Rnf10tm1b(KOMP)Wtsi HOM Female postnatal 2.7E-5
increased red blood cell distribution width Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 3.22E-5
convulsive seizures Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 4.05E-5
decreased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 5.14E-5
decreased circulating bilirubin level Rnf10tm1a(KOMP)Wtsi HOM Female Male postnatal 5.5E-5
increased circulating triglyceride level Rnf10tm1a(KOMP)Wtsi HOM Male postnatal 6.07E-5
limb grasping Rnf10em1(IMPC)J HOM Female postnatal 6.76E-5
abnormal bone structure Rnf10em1(IMPC)J HOM Female postnatal 7.29E-5
increased cardiac muscle contractility Rnf10tm1b(KOMP)Wtsi HET Female Male postnatal 7.32E-5
increased circulating chloride level Rnf10tm1b(KOMP)Wtsi HOM Male postnatal 7.63E-5
decreased circulating LDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 8.62E-5
increased or absent threshold for auditory brainstem response Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.41E-5
decreased spleen weight Rnf10tm1b(KOMP)Wtsi HOM Female Male postnatal 9.65E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (4/4)
Adrenal gland 18 Yes (2/415) (14/20)
Aorta 22 Yes (16/24)
Blood 6 No
Blood vessel 4 No (4/4)
Bone 14 Yes (2/16)
Bone marrow 6 No
Brain 22 Yes (21/24)
Brainstem 22 No (15/24)
Brown adipose tissue 4 No (2/4)
Brown adipose tissue 18 Yes (14/20)
Cartilage tissue 22 No (11/24)
Cecum 12 Yes (12/383) (10/14)
Cerebellum 22 No (19/24)
Cerebral cortex 22 No (15/24)
Chest bone 10 Yes (10/12)
Colon 10 No (12/127) (10/12)
Cranium 6 No
Diaphragm 10 Yes (10/12)
Duodenum 8 Yes (2/127) (8/10)
Epididymis 12 Yes (18/134) (3/14)
Esophagus 18 Yes (7/415) (16/20)
Eye 22 Yes (5/24)
Gall bladder 18 Yes (10/20)
Gonadal fat pad 8 Yes (7/10)
Harderian gland 10 Yes (10/12)
Heart 22 Yes (19/24)
Hindlimb 10 Yes (6/12)
Hippocampus 22 No (15/24)
Hypothalamus 22 No (15/24)
Ileum 8 Yes (14/127) (9/10)
Jejunum 8 Yes (6/127) (8/10)
Kidney 22 Yes (18/584) (23/24)
Large intestine 22 Yes (10/584) (17/24)
Liver 22 Yes (13/24)
Lower urinary tract 22 No (15/24)
Lung 22 Yes (18/24)
Lymph node 22 Yes
Main olfactory bulb 6 Yes (6/8)
Mammary gland 22 Yes (4/24)
Mesenteric lymph node 10 Yes
Mesenteric adipose tissue 8 Yes (8/10)
Midbrain 10 No (11/12)
Esophagus 4 No (4/4)
Olfactory lobe 18 No (15/20)
Olfactory lobe 4 No (2/4)
Oral epithelium 10 No
Ovary 22 Yes (1/584) (10/24)
Oviduct 22 Yes (10/24)
Pancreas 22 Yes (5/584) (9/24)
Parathyroid gland 18 Yes (16/20)
Parotid gland 10 Yes (1/12)
Penis 10 Yes (5/12)
Peripheral nervous system 22 No (15/24)
Peyer's patch 4 No
Peyer's patch 18 No
Pituitary gland 22 Yes (17/24)
Prostate gland 22 Yes (12/584) (8/24)
Quadriceps 8 Yes (10/10)
Sciatic nerve 10 Yes (4/12)
Skeletal muscle 18 No (15/20)
Skeletal muscle tissue 4 No (4/4)
Skin 22 Yes (16/24)
Small intestine 22 No (9/584) (15/24)
Spinal cord 22 Yes (22/24)
Spleen 22 Yes (2/584) (11/24)
Stomach 22 Yes (12/584) (17/24)
Stomach pyloric region 10 No
Striatum 22 No (15/24)
Sublingual gland 10 Yes (1/12)
Submandibular gland 12 Yes (2/132) (3/14)
Testis 22 Yes (2/584) (12/24)
Thalamus 6 No (7/8)
Thymus 22 Yes (1/24)
Thyroid gland 22 Yes (15/584) (7/24)
Tongue 10 Yes (5/127) (10/12)
Trachea 22 Yes (21/24)
Trigeminal V nerve 12 Yes (10/14)
Urinary bladder 12 Yes (11/14)
Uterus 22 Yes (10/24)
Vagina 10 Yes (3/12)
Vas deferens 12 No (15/388) (2/14)
Vascular system 18 No (9/20)
Vesicular gland 12 Yes (3/14)
White adipose tissue 22 Yes (6/24)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(17)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/47)
Axial skeleton 2 (1/51)
Brain 9 (6/485) (8/12)
Central nervous system ganglion 2 (1/51)
Dorsal root ganglion 3 (1/47)
Ear 9 (1/485) (7/12)
Embryo 9 (1/485) (11/12)
Outer ear 2 (1/47) (2/2)
Eye 9 (1/485) (10/12)
Foot 9 (1/485) (4/12)
Forearm 5 (1/282) (5/5)
Forebrain 9 (1/485) (8/12)
Forelimb 9 (1/485) (11/12)
Fronto-nasal process 3 (1/48) (2/3)
Gut 2 (1/50) (2/2)
Hand 9 (1/485) (4/12)
Head 9 (5/485) (9/12)
Head mesenchyme 2 (1/47)
Heart 9 (1/485) (4/12)
Heart ventricle 2 (1/47)
Hindbrain 9 (6/485) (8/12)
Hindlimb 9 (1/485) (11/12)
Intestine 2 (1/47) (2/2)
Liver 9 (1/485) (2/12)
Lower leg 5 (1/282) (5/5)
Lung 9 (1/485) (2/12)
Mandibular process 9 (1/485) (8/12)
Maxillary process 9 (1/485) (8/12)
Meckel's cartilage 2
Midbrain 9 (1/485) (7/12)
Nasal septum 2 (1/47)
Nose 3 (1/51) (3/3)
Notochord 2 (1/47) (2/2)
Oral cavity 9 (1/485) (3/12)
Outflow tract 2 (1/47)
Pericardium 1 (1/46)
Pharynx 2 (1/46) (2/2)
2 (7/25)
Radius-ulna pre-cartilage condensation 2 (1/46) (2/2)
Rib pre-cartilage condensation 2 (1/46)
Skeleton 2 (1/51)
Skin 9 (1/485) (4/12)
Spinal cord 3 (1/50) (1/3)
Tail 9 (1/485) (11/12)
Tail somite 9 (1/485) (8/12)
Thoracic vertebral cartilage condensation 2 (1/46)
Tongue 2 (1/46)
Trachea 1 (1/50)
Trunk mesenchyme 2 (1/47)
Upper arm 5 (1/282) (3/5)
Upper leg 5 (1/282) (3/5)
Vibrissa 2 (1/47) (2/2)
  • alimentary system(2)
    Mandibular process ambiguous
    Maxillary process ambiguous
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb


Secondary lacZ Expression Data
postnatal mouse (43)
  • Rnf10tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    bone, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    mesenteric lymph node, lymph node, HET, Female, WTSI

show all 43 images

trunk (29)
  • Rnf10tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI

show all 29 images

digestive system (9)
  • Rnf10tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    oesophagus, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    gall bladder, HET, Male, WTSI

show all 9 images

nervous system (7)
  • Rnf10tm1a(KOMP)Wtsi
    peripheral nervous system, pituitary gland, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    hypothalamus, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI

show all 7 images

reproductive system (5)
  • Rnf10tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    uterus, ovary, oviduct, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
cardiovascular system (4)
  • Rnf10tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    blood vessel, spleen, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    aorta, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    blood vessel, HET, Female, WTSI
endocrine system (4)
  • Rnf10tm1a(KOMP)Wtsi
    trachea, parathyroid gland, thyroid gland, HET, Male, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    adrenal gland, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    parathyroid gland, HET, Female, WTSI
urinary system (4)
  • Rnf10tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    lower urinary tract, HET, Male, WTSI
immune system (3)
  • Rnf10tm1a(KOMP)Wtsi
    mesenteric lymph node, lymph node, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    blood vessel, spleen, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    thymus, HET, Female, WTSI
respiratory system (3)
  • Rnf10tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    trachea, parathyroid gland, thyroid gland, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    lung, HET, Female, WTSI
integumental system (2)
  • Rnf10tm1a(KOMP)Wtsi
    skin, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    skin, HET, Female, WTSI
adipose tissue (1)
  • Rnf10tm1a(KOMP)Wtsi
    brown adipose tissue, HET, Female, WTSI
exocrine system (1)
  • Rnf10tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
musculoskeletal system (1)
  • Rnf10tm1a(KOMP)Wtsi
    bone, HET, Female, WTSI
sensory organ (1)
  • Rnf10tm1a(KOMP)Wtsi
    eye, HET, Female, WTSI
set of connective tissues (1)
  • Rnf10tm1a(KOMP)Wtsi
    brown adipose tissue, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    153 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    78 Images
  • X-ray: XRay Images Dorso Ventral
    179 Images
  • Echo: M-Mode Images
    32 Images
  • Adult LacZ: LacZ Images Wholemount
    505 Images
  • Embryo LacZ: LacZ images wholemount
    87 Images
  • X-ray: XRay Images Skull Lateral Orientation
    62 Images
  • X-ray: XRay Images Hind Leg and Hip
    14 Images
  • X-ray: XRay Images Forepaw
    50 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
Legacy Phenotype Associated Images
Xray (155)
  • Rnf10tm1a(KOMP)Wtsi
    body, HOM, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    head, WT, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Rnf10tm1a(KOMP)Wtsi
    body, WT, Female, WTSI

show all 155 images

Brain Histopathology (9)
  • Rnf10tm1b(KOMP)Wtsi
    anterior commissure, decreased anterior commissure size, HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    corpus callosum, decreased corpus callosum size, HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    primary motor cortex, decreased primary motor cortex size, HOM, Male, WTSI

show all 9 images

Histology Slide (4)
  • Rnf10tm1b(KOMP)Wtsi
    TS20 eye, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Male, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    TS20 maxillary process, HET, Female, WTSI
  • Rnf10tm1b(KOMP)Wtsi
    TS20 forebrain, HET, Female, WTSI
Skin Histopathology (1)
  • Rnf10tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rnf10em1(IMPC)J Exon Deletion
Vector
Gene
Rnf10em1(IMPC)Mbp Indel causing a Frameshift Mutation
Vector
Gene
Fixed Tissue
Rnf10tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rnf10tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Rnf10em1(IMPC)Bay Exon Deletion
Vector
Gene
Rnf10tm303169(L1L2_Bact_P)
Vector
Gene