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Gene: Chst4 MGI:1349479

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

carbohydrate sulfotransferase 4

Synonyms:

high endothelial cell GlcNAC-6-sulphotransferase, GST-3, HEC-GlcNAc6ST

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chst4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Chst4 (0 diseases)
Human diseases predicted to be associated with Chst4 (235 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chst4 by phenotypic similarity.

Disease	Matching phenotypes	Source
Hepatic Venoocclusive Disease With Immunodeficiency	Decreased circulating IgG level, Absence of lymph node germinal center	OMIM:235550
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency	Lymphadenopathy	ORPHA:319600
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)	Abnormal lymph node morphology	OMIM:136580
Immunodeficiency With Hyper-Igm, Type 3	Impaired Ig class switch recombination, Absence of lymph node germinal center, Impaired memory B ...	OMIM:606843
Immunodeficiency 38 With Basal Ganglia Calcification	Lymphadenopathy	OMIM:616126
Immunodeficiency With Hyper-Igm, Type 5	Impaired Ig class switch recombination, Lymphadenopathy, Increased circulating IgM level, Decreas...	OMIM:608106
Immunodeficiency With Hyper-Igm, Type 2	Impaired Ig class switch recombination, Lymphadenopathy, Increased circulating IgM level, Decreas...	OMIM:605258
Hereditary Progressive Mucinous Histiocytosis	Lymphadenopathy	ORPHA:158025
Kimura Disease	Increased circulating IgE level, Lymphadenopathy, Follicular hyperplasia	ORPHA:482
Squamous Cell Carcinoma Of The Esophagus	Lymphadenopathy	ORPHA:99977
Pulmonary Nodular Lymphoid Hyperplasia	Mediastinal lymphadenopathy, Follicular hyperplasia	ORPHA:60026
Reticuloendotheliosis, X-Linked	Hepatosplenomegaly, Lymphadenopathy	OMIM:312500
Lymphoproliferative Syndrome 3	Hepatosplenomegaly, Partial absence of specific antibody response to tetanus vaccine, Decreased c...	OMIM:618261
Mantle Cell Lymphoma	Splenomegaly, Lymphadenopathy	ORPHA:52416
Immunodeficiency 75 With Lymphoproliferation	Hepatosplenomegaly, Lymphadenopathy, Follicular hyperplasia	OMIM:619126
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia	Decreased circulating total IgM, Cervical lymphadenopathy, Decreased circulating IgG level	OMIM:618987
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant	Splenomegaly, Lymphadenopathy, Increased circulating IgM level, Decreased circulating IgG2 level,...	OMIM:615513
Caspase 8 Deficiency	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc...	OMIM:607271
Kerion Celsi	Lymphadenopathy	ORPHA:499
Mast Cell Sarcoma	Mastocytosis, Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:66661
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias	Absent specific antibody response, Decreased circulating antibody level, Lymphadenopathy, Follicu...	OMIM:619846
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation	Hepatosplenomegaly, Increased circulating IgG level, Increased circulating IgE level, Lymphadenop...	OMIM:618982
Immunodeficiency 78 With Autoimmunity And Developmental Delay	Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy, Fluctuating sp...	OMIM:619220
Immunodeficiency, Common Variable, 2	Impaired T cell function, Follicular hyperplasia, Splenomegaly, Lymphadenopathy, Decreased circul...	OMIM:240500
Rosaï-Dorfman Disease	Dysgammaglobulinemia, Lymphadenopathy	ORPHA:158014
Adenocarcinoma Of The Esophagus	Lymphadenopathy	ORPHA:99976
Immunodeficiency 64 With Lymphoproliferation	Increased circulating IgA level, Splenomegaly, Mediastinal lymphadenopathy, Cervical lymphadenopa...	OMIM:618534
Immunodeficiency With Hyper-Igm, Type 4	Impaired Ig class switch recombination, Absence of lymph node germinal center	OMIM:608184
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Splenomegaly, Mediastinal lymphadenopathy, Decreased specific anti-polysaccharide antibody level,...	OMIM:300853
Immunodeficiency 109 With Lymphoproliferation	Generalized lymphadenopathy, Splenomegaly, Decreased circulating IgG level, Complete or near-comp...	OMIM:620282
Mu-Heavy Chain Disease	Splenomegaly, Increased circulating antibody level, Lymphadenopathy	ORPHA:100024
Alpha-Heavy Chain Disease	Splenomegaly, Dysgammaglobulinemia, Lymphadenopathy	ORPHA:100025
Immunodeficiency 105	Absence of lymph node germinal center, Hepatosplenomegaly, Decreased circulating antibody level, ...	OMIM:619924
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy, Abnormal natural killer cell...	OMIM:613101
Immunodeficiency 32A	Lymphadenitis, Lymphadenopathy	OMIM:614893
Immunodeficiency 104	Splenomegaly, Lymphadenopathy	OMIM:608971
Deafness, Autosomal Dominant 34, With Or Without Inflammation	Lymphadenopathy	OMIM:617772
Immunodeficiency 52	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy	OMIM:617514
Immunodeficiency, Common Variable, 1	Impaired T cell function, Splenomegaly, Lymphadenopathy, Decreased circulating total IgM, Decreas...	OMIM:607594
Autoinflammation With Episodic Fever And Lymphadenopathy	Splenomegaly, Recurrent tonsillitis, Lymphadenopathy	OMIM:618852
Immunodeficiency 103, Susceptibility To Fungal Infections	Increased circulating IgE level, Lymphadenopathy	OMIM:212050
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Increased circulating IgE level, Lack of T cell function, Absent tonsils, Absence of lymph node g...	ORPHA:277
Indolent Systemic Mastocytosis	Splenomegaly, Lymphadenopathy, Increased proportion of CD25+ mast cells, Mastocytosis, Abnormal m...	ORPHA:98848
Immunodeficiency 27A	Splenomegaly, Enlarged mesenteric lymph node, Lymphadenopathy, Increased circulating IgG level, H...	OMIM:209950
Autoimmune Lymphoproliferative Syndrome, Type Iii	Generalized lymphadenopathy, Follicular hyperplasia, Reduced natural killer cell activity, Medias...	OMIM:615559
Follicular Lymphoma	Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:545
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:444463
Nodular Lymphocyte Predominant Hodgkin Lymphoma	Splenomegaly, Lymphadenopathy	ORPHA:86893
Activated Pi3K-Delta Syndrome	Splenomegaly, Recurrent tonsillitis, Decreased circulating antibody level, Lymphadenopathy, Incre...	ORPHA:397596
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	Splenomegaly, Increased circulating IgG level, Lymphadenopathy	OMIM:618495
Granulomatous Slack Skin	Abnormal lymph node morphology	ORPHA:33111
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia	Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology	ORPHA:97290
Schnitzler Syndrome	Splenomegaly, Increased circulating IgM level, Lymphadenopathy	ORPHA:37748
Familial Papillary Or Follicular Thyroid Carcinoma	Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology	ORPHA:319487
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency	Absent peripheral lymph nodes in presence of infection, Abnormal immunoglobulin level, Increased ...	ORPHA:98813
Immunodeficiency 27B	Generalized lymphadenopathy	OMIM:615978
Immunodeficiency With Hyper-Igm, Type 1	Dysgammaglobulinemia, Impaired Ig class switch recombination, Absence of lymph node germinal cent...	OMIM:308230
Lymphoproliferative Syndrome, X-Linked, 1	Dysgammaglobulinemia, Reduced natural killer cell activity, Splenomegaly, Decreased circulating a...	OMIM:308240
Autoimmune Lymphoproliferative Syndrome	Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Increased circulating IgA level, S...	OMIM:601859
Immunodeficiency 76	Splenomegaly, Lymphadenopathy	OMIM:619164
Ras-Associated Autoimmune Leukoproliferative Disorder	Splenomegaly, Increased circulating antibody level, Follicular hyperplasia	OMIM:614470
Generalized Eruptive Histiocytosis	Lymphadenopathy	ORPHA:157991
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy, Decreased circulating total ...	OMIM:616100
Laryngeal Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100083
Burkitt Lymphoma	Abnormality of the spleen, Abnormal lymph node morphology	ORPHA:543
Papa Syndrome	Increased circulating antibody level, Lymphadenopathy	ORPHA:69126
Tularemia	Abnormal nasopharyngeal adenoid morphology, Cervical lymphadenopathy, Mediastinal lymphadenopathy...	ORPHA:3392
Fish-Eye Disease	Splenomegaly, Lymphadenopathy	ORPHA:79292
Lymphoproliferative Syndrome 2	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy, Hepatosplenomegaly	OMIM:615122
Autoimmune Lymphoproliferative Syndrome, Type Iia	Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Increased circulating IgA level, S...	OMIM:603909
Pfapa Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:42642
Hemophagocytic Lymphohistiocytosis, Familial, 4	Splenomegaly, Lymphadenopathy	OMIM:603552
Boutonneuse Fever	Increased circulating IgG level, Cervical lymphadenopathy, Increased circulating IgM level, Lymph...	ORPHA:83313
Classic Hodgkin Lymphoma	Splenomegaly, Bone marrow hypocellularity, Lymphadenopathy	ORPHA:391
Mycosis Fungoides	Lymphadenopathy	OMIM:254400
Proteasome-Associated Autoinflammatory Syndrome 2	Increased circulating IgG level, Abnormal circulating IgM level, Increased circulating IgA level,...	OMIM:618048
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Generalized lymphadenopathy, Aplasia of the thymus, Splenomegaly, Increased circulating IgE level...	OMIM:602450
Roifman Syndrome	Decreased circulating antibody level, Decreased T cell activation, Lymphadenopathy, Hepatosplenom...	ORPHA:353298
Sézary Syndrome	Splenomegaly, Abnormal immunoglobulin level, Lymphadenopathy	ORPHA:3162
Leukocyte Adhesion Deficiency, Type Iii	Splenomegaly, Abnormal lymph node morphology, Hepatosplenomegaly	OMIM:612840
Leishmaniasis	Splenomegaly, Increased circulating antibody level, Lymphadenopathy	ORPHA:507
Familial Cold Autoinflammatory Syndrome 2	Splenomegaly, Lymphadenopathy	OMIM:611762
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies	Decreased circulating antibody level, Lymphadenopathy, Hepatosplenomegaly	OMIM:619750
Pseudomyxoma Peritonei	Lymphadenopathy	ORPHA:26790
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency	Increased circulating IgA level, Increased circulating IgE level, Lymphadenopathy, Hepatosplenome...	ORPHA:169154
Classic Mycosis Fungoides	Splenomegaly, Lymphadenopathy	ORPHA:2584
Pleural Mesothelioma	Lymphadenopathy	ORPHA:50251
Lymphoproliferative Syndrome 1	Splenomegaly, Decreased circulating antibody level, Decreased circulating IgG level, Lymphadenopathy	OMIM:613011
Immunodeficiency 97 With Autoinflammation	Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy, Hepatosplenomegaly, Decreased circula...	OMIM:619802
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Abnormality of B cell physiology, Cutaneous anergy, Panhypogammaglobulinemia, Absent peripheral l...	OMIM:600802
Granulomatous Disease, Chronic, Autosomal Recessive, 5	Splenomegaly, Lymphadenitis, Recurrent tonsillitis, Lymphadenopathy, Hepatosplenomegaly, Impaired...	OMIM:618935
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy, Decreased circulating total ...	ORPHA:436159
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome	Splenomegaly, Lymphadenopathy	OMIM:150550
Congenital Toxoplasmosis	Lymphadenopathy	ORPHA:858
Griscelli Syndrome	Splenomegaly, Decreased circulating antibody level, Bone marrow hypocellularity, Lymphadenopathy	ORPHA:381
Cold Agglutinin Disease	Splenomegaly, Lymphadenopathy	ORPHA:56425
Immunodeficiency 98 With Autoinflammation, X-Linked	Splenomegaly, Decreased circulating IgG level, Bone marrow hypocellularity, Lymphadenopathy	OMIM:301078
Immunodeficiency 54	Splenomegaly, Lymphadenopathy	OMIM:609981
Middle Ear Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100084
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia	Generalized lymphadenopathy, Partial absence of specific antibody response to Haemophilus influen...	OMIM:618986
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency	Splenomegaly, Lymphadenopathy	OMIM:619375
Deafness-Lymphedema-Leukemia Syndrome	Splenomegaly, Bone marrow hypocellularity, Lymphadenopathy	ORPHA:3226
Corticosteroid-Sensitive Aseptic Abscess Syndrome	Abnormality of the lymphatic system, Abnormal lymph node morphology	ORPHA:54251
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Increased circulating IgM level, Increased circulating IgA level, Lymphadenopathy	OMIM:617099
Heme Oxygenase 1 Deficiency	Asplenia, Cervical lymphadenopathy, Lymphadenopathy	OMIM:614034
Systemic-Onset Juvenile Idiopathic Arthritis	Splenomegaly, Lymphadenopathy	ORPHA:85414
Immunodeficiency 7	Splenomegaly, Lymphadenopathy	OMIM:615387
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity	Increased circulating IgE level, Enlarged tonsils, Decreased specific anti-polysaccharide antibod...	OMIM:606367
Aggressive Systemic Mastocytosis	Hypersplenism, Lymphadenopathy, Hepatosplenomegaly, Increased proportion of CD25+ mast cells, Abn...	ORPHA:98850
Immunodeficiency 10	Lymphadenopathy	OMIM:612783
Nephroblastoma	Lymphadenopathy	ORPHA:654
Cinca Syndrome	Lymphadenopathy, Hepatosplenomegaly	OMIM:607115
Hyperimmunoglobulinemia D With Periodic Fever	Increased circulating IgA level, Lymphadenopathy	ORPHA:343
Griscelli Syndrome Type 2	Splenomegaly, Lymphadenopathy	ORPHA:79477
Acquired Hypertrichosis Lanuginosa	Lymphadenopathy	ORPHA:2221
Combined Immunodeficiency Due To Zap70 Deficiency	Lymphadenitis, Abnormal lymph node morphology, Lymphadenopathy, Hepatosplenomegaly	ORPHA:911
Rhabdoid Tumor	Lymphadenopathy	ORPHA:69077
Immunodeficiency, Common Variable, 8, With Autoimmunity	Generalized lymphadenopathy, Splenomegaly, Lymphadenopathy, Decreased circulating total IgM, Decr...	OMIM:614700
Squamous Cell Carcinoma Of The Anal Canal	Lymphadenopathy	ORPHA:424019
Roifman Syndrome	Splenomegaly, Lymphadenopathy	OMIM:616651
Thyroid Lymphoma	Lymphadenopathy	ORPHA:97285
Hyper-Igd Syndrome	Increased circulating IgA level, Splenomegaly, Lymphadenitis, Lymphadenopathy, Hepatosplenomegaly...	OMIM:260920
Desmoplastic Small Round Cell Tumor	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:83469
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	Increased circulating IgE level, Lymphadenopathy	OMIM:304790
Cutaneous Mastocytoma	Lymphadenopathy	ORPHA:79455
Proteasome-Associated Autoinflammatory Syndrome 4	Splenomegaly, Lymphadenopathy	OMIM:619183
Familial Hemophagocytic Lymphohistiocytosis	Splenomegaly, Decreased circulating antibody level, Reduced natural killer cell activity, Lymphad...	ORPHA:540
Pulmonary Non-Tuberculous Mycobacterial Infection	Lymphadenopathy	ORPHA:411703
Proteasome-Associated Autoinflammatory Syndrome 3	Splenomegaly, Increased circulating antibody level, Lymphadenopathy	OMIM:617591
Niemann-Pick Disease, Type A	Splenomegaly, Lymphadenopathy	OMIM:257200
Granulomatous Disease, Chronic, Autosomal Recessive, 1	Splenomegaly, Lymphadenitis, Impaired oxidative burst, Lymphadenopathy	OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2	Splenomegaly, Lymphadenitis, Impaired oxidative burst, Lymphadenopathy	OMIM:233710
Klatskin Tumor	Lymphadenopathy	ORPHA:99978
Melkersson-Rosenthal Syndrome	Lymphadenopathy	ORPHA:2483
Multiple Myeloma	Increased circulating IgA level, Splenomegaly, Decreased circulating antibody level, Lymphadenopa...	ORPHA:29073
Felty Syndrome	Splenomegaly, Bone marrow hypocellularity, Lymphadenopathy	ORPHA:47612
Cyclic Neutropenia	Cervical lymphadenopathy, Recurrent tonsillitis, Lymphadenopathy	ORPHA:2686
Immunodeficiency 91 And Hyperinflammation	Lymphadenopathy, Hepatosplenomegaly	OMIM:619644
Medullary Thyroid Carcinoma	Lymphadenopathy	ORPHA:1332
Granulomatous Disease, Chronic, Autosomal Recessive, 4	Splenomegaly, Lymphadenitis, Impaired oxidative burst, Lymphadenopathy	OMIM:233690
Sting-Associated Vasculopathy, Infantile-Onset	Increased circulating IgG level, Follicular hyperplasia, Increased circulating IgA level, Paratra...	OMIM:615934
Anaplastic Thyroid Carcinoma	Lymphadenopathy	ORPHA:142
American Trypanosomiasis	Splenomegaly, Lymphadenopathy	ORPHA:3386
Scrub Typhus	Splenomegaly, Lymphadenopathy	ORPHA:83317
Adult-Onset Still Disease	Splenomegaly, Generalized lymphadenopathy, Bone marrow hypocellularity	ORPHA:829
Primary Myelofibrosis	Splenomegaly, Lymphadenopathy, Hepatosplenomegaly	ORPHA:824
Mevalonic Aciduria	Fluctuating splenomegaly, Increased circulating IgD level, Lymphadenopathy, Hepatosplenomegaly	OMIM:610377
Hemophagocytic Lymphohistiocytosis, Familial, 2	Splenomegaly, Reduced natural killer cell activity, Lymphadenopathy, Hepatosplenomegaly	OMIM:603553
Diffuse Cutaneous Mastocytosis	Abnormality of the spleen, Lymphadenopathy	ORPHA:79456
Pancreatoblastoma	Abnormal lymph node morphology	ORPHA:677
Thymic Neuroendocrine Tumor	Neoplasm of the thymus, Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy	ORPHA:97289
Omenn Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:39041
Aregenerative Anemia	Bone marrow hypocellularity, Lymphadenopathy	ORPHA:101096
Legionnaires Disease	Splenomegaly, Bone marrow hypocellularity, Lymphadenopathy	ORPHA:549
Castleman Disease	Mediastinal lymphadenopathy, Follicular hyperplasia, Generalized lymphadenopathy, Lymphadenopathy	ORPHA:160
Gamma-Heavy Chain Disease	Splenomegaly, Lymphadenopathy	ORPHA:100026
Omenn Syndrome	Splenomegaly, Hypoplasia of the thymus, Lymphadenopathy	OMIM:603554
Combined Immunodeficiency Due To Crac Channel Dysfunction	Splenomegaly, Lymphadenopathy	ORPHA:169090
Hereditary Amyloidosis With Primary Renal Involvement	Abnormal lymph node morphology, Lymphadenopathy, Hepatosplenomegaly	ORPHA:85450
Cinca Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:1451
Common Variable Immunodeficiency	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy	ORPHA:1572
Meige Disease	Lymph node hypoplasia, Absence of lymph node germinal center	ORPHA:90186
Igg4-Related Submandibular Gland Disease	Increased circulating IgG4 level, Increased circulating IgE level, Lymphadenopathy, Increased cir...	ORPHA:449432
Autoimmune Lymphoproliferative Syndrome	Chronic noninfectious lymphadenopathy, Increased circulating IgA level, Hypersplenism, Splenomega...	ORPHA:3261
T-Cell Immunodeficiency With Thymic Aplasia	Oligoclonal T cell expansion, Aplasia of the thymus, Lymphadenopathy	ORPHA:83471
Selective Igm Deficiency	Lymphadenitis, Paraproteinemia, Lymphadenopathy, Decreased circulating total IgM, Decreased speci...	ORPHA:331235
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome	Absence of lymph node germinal center, Panhypogammaglobulinemia, Hepatosplenomegaly	ORPHA:79124
Joint Contractures, Osteochondromas, And B-Cell Lymphoma	Generalized lymphadenopathy	OMIM:620232
Hypocomplementemic Urticarial Vasculitis	Splenomegaly, Lymphadenopathy	ORPHA:36412
Macrophage Activation Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:158061
Waldenström Macroglobulinemia	Splenomegaly, Monoclonal immunoglobulin M proteinemia, Lymphadenopathy	ORPHA:33226
Cutaneous Neuroendocrine Carcinoma	Chronic noninfectious lymphadenopathy	ORPHA:79140
Mixed Connective Tissue Disease	Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:809
Poems Syndrome	Increased circulating antibody level, Lymphadenopathy	ORPHA:2905
Chediak-Higashi Syndrome	Impaired neutrophil bactericidal activity, Splenomegaly, Lymphadenopathy	OMIM:214500
Lig4 Syndrome	Lymphadenopathy	ORPHA:99812
Granulomatous Disease, Chronic, X-Linked	Splenomegaly, Lymphadenitis, Impaired oxidative burst, Lymphadenopathy	OMIM:306400
Acute Interstitial Pneumonia	Lymphadenopathy	ORPHA:79126
Malt Lymphoma	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:52417
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency	Splenomegaly, Lymphadenitis, Lymphadenopathy	OMIM:615895
Hennekam Syndrome	Splenomegaly, Pulmonary lymphangiectasia, Lymphadenopathy, Decreased circulating antibody level, ...	ORPHA:2136
Systemic Mastocytosis With Associated Hematologic Neoplasm	Splenomegaly, Abnormal mast cell morphology, Lymphadenopathy	ORPHA:98849
Q Fever	Splenomegaly, Increased circulating antibody level, Lymphadenopathy, Hepatosplenomegaly	ORPHA:781
Pulmonary Capillary Hemangiomatosis	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:199241
Hemophagocytic Lymphohistiocytosis, Familial, 1	Splenomegaly, Lymphadenopathy	OMIM:267700
Acute Promyelocytic Leukemia	Lymphadenopathy	ORPHA:520
Carney Triad	Mediastinal lymphadenopathy, Lymphadenopathy	ORPHA:139411
Drug Reaction With Eosinophilia And Systemic Symptoms	Lymphadenopathy	ORPHA:139402
Graft Versus Host Disease	Lymphadenopathy, Hepatosplenomegaly	ORPHA:39812
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome	Splenomegaly, Decreased circulating antibody level, Lymphadenopathy, Hepatosplenomegaly, Bone mar...	OMIM:615688
Lymphatic Filariasis	Lymphadenitis, Abnormality of the lymphatic system, Lymphangiectasis, Lymphadenopathy	ORPHA:2035
Pediatric Systemic Lupus Erythematosus	Lymphadenopathy	ORPHA:93552
Farber Disease	Lymphadenopathy, Hepatosplenomegaly	ORPHA:333
Riddle Syndrome	Decreased circulating IgG level, Decreased circulating total IgM, Generalized lymphadenopathy, De...	ORPHA:420741
Kikuchi-Fujimoto Disease	Generalized lymphadenopathy, Splenomegaly, Cervical lymphadenopathy, Abnormal lymph node morpholo...	ORPHA:50918
Chédiak-Higashi Syndrome	Splenomegaly, Lymphadenopathy, Hepatosplenomegaly, Increased proportion of CD25+ mast cells, Abno...	ORPHA:167
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Splenomegaly, Increased circulating IgE level, Lymphadenopathy	ORPHA:37042
Acute Generalized Exanthematous Pustulosis	Lymphadenopathy	ORPHA:293173
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia	Cervical lymphadenopathy, Lymphadenopathy	OMIM:617718
Immunodeficiency 55	Lymphadenopathy	OMIM:617827
Coccidioidomycosis	Abnormality of the spleen, Mediastinal lymphadenopathy, Lymphadenopathy, Increased circulating Ig...	ORPHA:228123
Histiocytosis-Lymphadenopathy Plus Syndrome	Splenomegaly, Cervical lymphadenopathy, Lymphadenopathy, Hepatosplenomegaly	OMIM:602782
Familial Pancreatic Carcinoma	Lymphadenopathy, Hepatosplenomegaly	ORPHA:1333
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2	Accessory spleen, Splenomegaly, Polysplenia, Lymphadenopathy	OMIM:619418
Igg4-Related Dacryoadenitis And Sialadenitis	Increased circulating IgM level, Increased circulating IgA level, Increased circulating IgG4 leve...	ORPHA:79078
H Syndrome	Lymphadenopathy, Hepatosplenomegaly	ORPHA:168569
Cherubism	Submandibular lymph node enlargement	OMIM:118400
Tangier Disease	Orange discolored tonsils, Chronic noninfectious lymphadenopathy, Hepatosplenomegaly	ORPHA:31150
Sarcoidosis, Susceptibility To, 1	Abnormality of T cell physiology, Generalized lymphadenopathy, Splenomegaly, Mediastinal lymphade...	OMIM:181000
Immunodeficiency 82 With Systemic Inflammation	Follicular hyperplasia, Splenomegaly, Lymphadenopathy, Decreased circulating total IgA, Decreased...	OMIM:619381
Adenocarcinoma Of The Anal Canal	Lymphadenopathy	ORPHA:424016
Spondyloenchondrodysplasia With Immune Dysregulation	Lymphadenopathy	OMIM:607944
Lymphangioleiomyomatosis	Pulmonary lymphangiomyomatosis, Abnormality of the lymphatic system, Lymphadenopathy	ORPHA:538
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Lymphadenopathy, Hepatosplenomegaly	ORPHA:85408
Gallbladder Neuroendocrine Tumor	Chronic noninfectious lymphadenopathy	ORPHA:100086
Igg4-Related Kidney Disease	Increased circulating IgG4 level, Lymphadenitis, Increased circulating IgE level, Lymphadenopathy...	ORPHA:449395
Brucellosis	Hypersplenism, Splenomegaly, Lymphadenopathy, Increased circulating IgG level, Increased circulat...	ORPHA:1304
Immunodeficiency 31C	Splenomegaly, Lymphadenopathy	OMIM:614162
Igg4-Related Ophthalmic Disease	Increased circulating IgE level, Increased circulating IgG4 level, Lymphadenopathy	ORPHA:449563
Proteasome-Associated Autoinflammatory Syndrome 1	Increased circulating IgA level, Splenomegaly, Lymphadenopathy, Increased circulating IgG level, ...	OMIM:256040
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:32960
Familial Mediterranean Fever	Splenomegaly, Lymphadenopathy	ORPHA:342
Ileal Neuroendocrine Tumor	Lymphadenopathy	ORPHA:100078
Primary Sjögren Syndrome	Decreased circulating antibody level, Increased circulating antibody level, Lymphadenopathy	ORPHA:289390
Chikungunya	Cervical lymphadenopathy, Lymphadenopathy	ORPHA:324625
Crimean-Congo Hemorrhagic Fever	Splenomegaly, Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy	ORPHA:99827
Autosomal Recessive Malignant Osteopetrosis	Splenomegaly, Lymphadenopathy	ORPHA:667
Marburg Hemorrhagic Fever	Increased circulating antibody level, Lymphadenopathy	ORPHA:99826
Behçet Disease	Splenomegaly, Lymphadenopathy	ORPHA:117
Systemic Lupus Erythematosus	Lymphadenopathy	ORPHA:536
Sarcoidosis	Abnormal lymph node morphology, Lymphadenopathy	ORPHA:797
Blau Syndrome	Splenomegaly, Lymphadenopathy	ORPHA:90340
Cushing Syndrome Due To Ectopic Acth Secretion	Neoplasm of the thymus, Abnormal lymph node morphology	ORPHA:99889
African Trypanosomiasis	Splenomegaly, Hepatosplenomegaly, Lymphadenopathy	ORPHA:3385
Leptospirosis	Lymphadenopathy	ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chst4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chst4.

No publications found that use IMPC mice or data for Chst4.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Chst4^{tm96744(L1L2_Bact_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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