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Genes Phenotypes Help, News, Blog

Gene: Spag1 MGI:1349387

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
sperm associated antigen 1
Synonyms:
TPR-containing protein involved in spermatogenesis,  tpis

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Spag1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Spag1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Spag1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
SPAG17 mediates nuclear translocation of protamines during spermiogenesis. Frontiers in cell and developmental biology (September 2023) Spag17tm1b(KOMP)Wtsi PMC10520709
Analysis of the sperm flagellar axoneme using gene-modified mice. Experimental animals (June 2020) Spag17tm1b(KOMP)Wtsi PMC7677079
SPAG17 Is Required for Male Germ Cell Differentiation and Fertility. International journal of molecular sciences (April 2018) Spag17tm1b(KOMP)Wts1 PMC5979577
Spag17 deficiency results in skeletal malformations and bone abnormalities. PloS one (May 2015) Spag17tm1d(KOMP)Wtsi PMC4446355
Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival. American journal of respiratory cell and molecular biology (June 2013) Spag17tm1c(KOMP)Wtsi Spag17tm1a(KOMP)Wtsi Spag17tm1d(KOMP)Wtsi PMC3727877

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Spag1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Spag1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Spag1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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