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Genes Phenotypes Help, News, Blog

Gene: Usp5 MGI:1347343

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Gene Summary

Name:
ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms:
Ucht

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Usp5tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased leukocyte cell number Usp5tm1a(EUCOMM)Hmgu HET   Early adult 5.45×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

4 Images

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X-ray

XRay Images Whole Body Dorso Ventral

4 Images

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DSS Histology

Images

8 Images

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Anti-nuclear antibody assay

Images

6 Images

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X-ray

XRay Images Whole Body Lateral Orientation

4 Images

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X-ray

XRay Images Skull Lateral Orientation

4 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

4 Images

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Eye Morphology

Images Ophthalmoscopy

1 Images

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Ear epidermis immunophenotyping

Images

12 Images

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Legacy Phenotype Associated Images
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI

View all 97 images

Usp5tm1a(EUCOMM)Hmgu
WT, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
WT, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
lateral ventricle, enlarged lateral ventricles, HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
WT, Male, WTSI

View all 15 images

Usp5tm1a(EUCOMM)Hmgu
abnormal snout morphology, upturned snout, head, HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
kinked tail, HET, Male, WTSI
Usp5tm1a(EUCOMM)Hmgu
abnormal retinal pigmentation, HET, Male, WTSI

Human diseases caused by Usp5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Usp5 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Myelolymphatic Insufficiency
Leukopenia, Hyposegmentation of neutrophil nuclei OMIM:310350
Myeloproliferative Syndrome, Transient
Leukocytosis, Transient myeloproliferative syndrome OMIM:159595
Reticular Dysgenesis
Leukopenia, Congenital agranulocytosis, Lymphopenia, Hypoplasia of the thymus OMIM:267500
Acute Erythroid Leukemia
Anemia, Erythroid hypoplasia, Pancytopenia, Leukopenia ORPHA:318

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Usp5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Usp5.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Usp5tm1a(EUCOMM)Hmgu Usp51em1(IMPC)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Usp5tm1a(EUCOMM)Hmgu PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Usp5tm1a(EUCOMM)Hmgu Usp51em1(IMPC)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Usp5tm1a(EUCOMM)Hmgu PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Usp5tm1a(EUCOMM)Hmgu PMC5827107
The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis. Oncotarget (November 2016) Usp54tm1a(KOMP)Wtsi PMC5342676

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Usp5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Usp5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Usp5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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