Gene: Sufu

Order

Name SUFU negative regulator of hedgehog signaling

Synonyms
  • Su(Fu)
  • b2b273Clo
  • 2810026F04Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1345643    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Sufu

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sufu data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
abnormal embryo size Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal eye morphology Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
abnormal forebrain development Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal hindbrain development Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal limb bud morphology Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
abnormal liver size Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
abnormal midbrain development Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal neural tube closure Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal placenta size Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
abnormal stomach morphology Sufutm1b(KOMP)Wtsi HET Male postnatal 0.0
embryonic growth retardation Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Sufutm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
enlarged lymph nodes Sufutm1b(KOMP)Wtsi HET Male postnatal 0.0
pale liver Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
pale yolk sac Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
pallor Sufutm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Sufutm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased mean corpuscular volume Sufutm1b(KOMP)Wtsi HET Female postnatal 2.01E-5
decreased eosinophil cell number Sufutm1b(KOMP)Wtsi HET Female Male postnatal 6.22E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (1/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (1/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (1/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562) (1/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562)
Thymus 2 No
Thyroid gland 2 No (16/562) (1/2)
Trachea 2 No (3/562)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    sensory organ
    reproductive system exocrine system
    integumental system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 6 (6/440) Image Only
Ear 6 (1/440) Image Only
Embryo 6 (1/440) Image Only
Eye 6 (1/440) Image Only
Foot 6 Image Only
Forebrain 6 (1/440) Image Only
Forelimb 6 (1/440) Image Only
Hand 6 Image Only
Head 6 (5/440) Image Only
Heart 6 (1/440) Image Only
Hindbrain 6 (5/440) Image Only
Hindlimb 6 (1/440) Image Only
Liver 6 (1/440) Image Only
Lung 6 (1/440) Image Only
Mandibular process 6 (1/440) Image Only
Maxillary process 6 (1/440) Image Only
Midbrain 6 (1/440) Image Only
Oral cavity 6 (1/440) Image Only
Skin 6 (1/440) Image Only
Tail 6 (1/440) Image Only
Tail somite 6 (1/440) Image Only


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    24 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Adult LacZ: LacZ Images Section
    21 Images
  • Gross Pathology and Tissue Collection
    9 Images
  • Eye Morphology: Images Ophthalmoscopy
    2 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Sufutm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Sufutm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene