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Gene: Zeb2 MGI:1344407

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger E-box binding homeobox 2
Synonyms:
9130203F04Rik,  SIP1,  Zfx1b,  Zfhx1b,  D130016B08Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zeb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Zeb2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Delayed eruption of teeth, Polymicrogyria, Periventricular heterotopia ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Delayed eruption of teeth, Polymicrogyria, Periventricular heterotopia ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

The table below shows human diseases predicted to be associated to Zeb2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect, Type II lissencephaly OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida, Abnormality of neuronal migration ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Subependymal Nodular Heterotopia
Occipital encephalocele, Myelomeningocele, Meningocele, Abnormality of neuronal migration, Gray m... ORPHA:101030
Lambert Syndrome
Branchial anomaly ORPHA:1296
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Wildervanck Syndrome
Webbed neck, Meningocele, Low posterior hairline, Short neck ORPHA:3456
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Chiari Malformation Type Ii
Spina bifida, Myelomeningocele, Hydrocephalus, Gray matter heterotopia, Cervical myelopathy OMIM:207950
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Schisis Association
Encephalocele, Anencephaly, Spina bifida ORPHA:63862
Isolated Klippel-Feil Syndrome
Congenital muscular torticollis, Spina bifida, Short neck, Low posterior hairline, Webbed neck ORPHA:2345
Diaphanospondylodysostosis
Myelomeningocele, Short neck ORPHA:66637
Humero-Radial Synostosis
Meningocele ORPHA:3265
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Meckel Syndrome, Type 2
Encephalocele, Cystic hygroma, Meningocele, Anencephaly OMIM:603194
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Meningocele, Anencephaly OMIM:611134
X-Linked Mandibulofacial Dysostosis
Branchial anomaly, Webbed neck ORPHA:1131
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holoprosencephaly ORPHA:1908
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Limitation of neck motion, Neural tube defect, ... ORPHA:268810
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula ORPHA:50815
Verheij Syndrome
Branchial cyst, Short neck OMIM:615583
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Neurocutaneous Melanocytosis
Meningocele, Abnormality of neuronal migration ORPHA:2481
Enlarged Parietal Foramina
Occipital encephalocele, Myelomeningocele ORPHA:60015
Camptodactyly Syndrome, Guadalajara Type 1
Abnormality of dental eruption, Spina bifida ORPHA:1327
Czeizel-Losonci Syndrome
Thickened nuchal skin fold, Spina bifida, Myelomeningocele, Hydrocephalus, Spina bifida occulta ORPHA:2437
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Iniencephaly
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Lis... ORPHA:63259
Amish Lethal Microcephaly
Lissencephaly, Spina bifida ORPHA:99742
Triploidy
Hydrocephalus, Meningocele, Holoprosencephaly, Short neck ORPHA:3376
Bor Syndrome
Branchial cyst ORPHA:107
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Autosomal Recessive Spondylocostal Dysostosis
Umbilical hernia, Meningocele, Spina bifida occulta, Short neck ORPHA:2311
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Neu-Laxova Syndrome 2
Lissencephaly, Spina bifida, Short neck OMIM:616038
Cerebrocostomandibular Syndrome
Spina bifida, Myelomeningocele, Meningocele, Webbed neck, Hydranencephaly ORPHA:1393
Joubert Syndrome 14
Encephalocele, Hydrocephalus, Meningocele OMIM:614424
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Increased nuchal translucency, Gray matter heterotopia, Branchial anomaly, Cystic hygroma ORPHA:453499
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Holoprosencephaly
Encephalocele, Short neck, Hydrocephalus, Abnormality of neuronal migration, Spinal dysraphism, B... ORPHA:2162
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Lateral Meningocele Syndrome
Umbilical hernia, Meningocele, Low posterior hairline, Short neck ORPHA:2789
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele ORPHA:1827
Chromosome 17P13.1 Deletion Syndrome
Spina bifida, Short neck, Hydrocephalus, Webbed neck, Umbilical hernia, Broad neck OMIM:613776
Neu-Laxova Syndrome
Abnormal cortical gyration, Spina bifida, Pachygyria, Abnormality of neuronal migration, Macrogyr... ORPHA:2671
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Oligomeganephronia
Branchial cyst ORPHA:2260
Lateral Meningocele Syndrome
Umbilical hernia, Hydrocephalus, Meningocele, Short neck OMIM:130720
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele, Polymicrogyria OMIM:601707
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Short neck, Hydrocephalus, Anencephaly, Occipital meningocele, Polymicrogyria OMIM:616546
Trisomy 20P
Umbilical hernia, Low posterior hairline, Spina bifida, Short neck ORPHA:261318
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Increased nuchal translucency, Gray matter heterotopia, Branchial anomaly, Cystic hygroma ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Increased nuchal translucency, Gray matter heterotopia, Branchial anomaly, Cystic hygroma ORPHA:352665
Pagod Syndrome
Encephalocele, Meningocele, Abnormality of neuronal migration, Spina bifida ORPHA:991
Mosaic Trisomy 9
Webbed neck, Cystic hygroma, Spina bifida, Short neck ORPHA:99776
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Vacterl With Hydrocephalus
Aqueductal stenosis, Hydrocephalus, Spina bifida ORPHA:3412
Distal 22Q11.2 Microdeletion Syndrome
Branchial fistula ORPHA:261330
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Distal 22Q11.2 Microduplication Syndrome
Branchial fistula, Hydrocephalus, Low posterior hairline, Webbed neck ORPHA:261337
Limb Body Wall Complex
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Short umbilical cord, ... ORPHA:2369
Trisomy 18
Anencephaly, Holoprosencephaly, Spina bifida, Webbed neck ORPHA:3380
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Redundant neck skin, Occipital encephalocele, Meningocele ORPHA:397715
Treacher-Collins Syndrome
Encephalocele, Branchial fistula ORPHA:861
Nail-Patella Syndrome
Spina bifida OMIM:161200
Lathosterolosis
Meningocele ORPHA:46059
Fibular Hemimelia
Spina bifida ORPHA:93323
Orofaciodigital Syndrome Vi
Occipital meningocele, Periventricular nodular heterotopia, Polymicrogyria OMIM:277170
Aicardi Syndrome
Gray matter heterotopia, Pachygyria, Polymicrogyria, Spina bifida OMIM:304050
Phocomelia, Schinzel Type
Meningocele, Short neck ORPHA:2879
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Neu-Laxova Syndrome 1
Spina bifida, Short neck, Stillbirth, Lissencephaly, Short umbilical cord, Small placenta, Neonat... OMIM:256520
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Hallermann-Streiff Syndrome
Natal tooth, Spina bifida OMIM:234100
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Branchial cyst, Natal tooth OMIM:620186
Jacobsen Syndrome
Webbed neck, Pachygyria, Spina bifida, Short neck ORPHA:2308
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Split Cord Malformation
Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydrocephalus ORPHA:573278
8Q24.3 Microdeletion Syndrome
Branchial cyst, Spina bifida occulta, Short neck ORPHA:508488
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida, Short neck ORPHA:508498
Arima Syndrome
Gray matter heterotopia, Occipital meningocele OMIM:243910
Knobloch Syndrome 1
Occipital meningocele, Occipital encephalocele, Spina bifida occulta, Polymicrogyria OMIM:267750
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Torticollis, Spina bifida OMIM:619480
22Q11.2 Deletion Syndrome
Spina bifida, Short neck, Hydrocephalus, Meningocele, Occipital myelomeningocele, Umbilical hernia ORPHA:567
Campomelic Dysplasia
Hydrocephalus, Spina bifida, Spinal dysraphism OMIM:114290
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Branchiooculofacial Syndrome
Branchial anomaly, Low posterior hairline, Short neck OMIM:113620
Fanconi Anemia
Umbilical hernia, Hydrocephalus, Spina bifida ORPHA:84
Witteveen-Kolk Syndrome
Branchial fistula, Bilateral polymicrogyria OMIM:613406
Marfan Syndrome
Meningocele ORPHA:558
Vater/Vacterl Association
Occipital encephalocele, Spina bifida, Patent urachus OMIM:192350
Rubinstein-Taybi Syndrome 1
Spina bifida occulta, Spina bifida, Low posterior hairline OMIM:180849
Otopalatodigital Syndrome, Type Ii
Spina bifida, Short neck, Hydrocephalus, Stillbirth, Umbilical hernia OMIM:304120
Craniofacial Microsomia 1
Occipital encephalocele, Hydrocephalus, Branchial anomaly OMIM:164210
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele, Broad neck, Short neck OMIM:276820
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Delayed eruption of teeth, Polymicrogyria, Periventricular heterotopia ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Delayed eruption of teeth, Polymicrogyria, Periventricular heterotopia ORPHA:261552
Mowat-Wilson Syndrome
Delayed eruption of teeth OMIM:235730

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zeb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zeb2.

No publications found that use IMPC mice or data for Zeb2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Zeb2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zeb2tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zeb2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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