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Gene: Sh3bp5 MGI:1344391

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Gene Summary

Name:
SH3-domain binding protein 5 (BTK-associated)
Synonyms:
Sab

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sh3bp5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sh3bp5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sh3bp5.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology (Baltimore, Md.) (October 2021) Sh3bp5tm1a(KOMP)Wtsi Sh3bp5tm1b(KOMP)Wtsi PMC8639630
Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. The Journal of clinical investigation (December 2019) Sh3bp5tm1a(KOMP)Wtsi PMC6877311
The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell death & disease (June 2017) Sh3bp5tm1a(KOMP)Wtsi PMC5584575
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology (Baltimore, Md.) (March 2016) Sh3bp5tm1a(KOMP)Wtsi PMC4874901

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sh3bp5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sh3bp5tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Sh3bp5tm45925(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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