Gene: Mthfd2

Name methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

Synonyms NMDMC

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1338850   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Mthfd2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mthfd2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal cranium morphology Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal embryo development Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal embryo size Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal eye morphology Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal facial morphology Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal placenta size Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal umbilical cord morphology Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
embryonic growth retardation Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
microphthalmia Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
pale liver Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
pale yolk sac Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
pallor Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
preweaning lethality, incomplete penetrance Mthfd2tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Mesenteric lymph node 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Trigeminal V nerve 2 No
Urinary bladder 2 No
Uterus 2 No (2/562)
Vas deferens 2 No (1/360)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse nervous system set of connective tissues reproductive system musculoskeletal system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/3) (2/2)
Axial skeleton 2 (1/5) (2/2)
Brain 2 (6/440) (2/2)
Central nervous system ganglion 2 (1/5) (2/2)
Cranium 2 Image Only (2/2)
Dorsal root ganglion 2 (1/3) (2/2)
Ear 2 (1/440) (2/2)
Embryo 2 (1/440) (2/2)
Outer ear 2 (2/2)
Eye 2 (1/440) (2/2)
Femur pre-cartilage condensation 2 Image Only (2/2)
Foot 2 (2/2)
Forearm 2 (2/2)
Forebrain 2 (1/440) (2/2)
Forelimb 2 (1/440) (2/2)
Fronto-nasal process 2 (1/4) (2/2)
Gut 2 (1/4) (2/2)
Hand 2 (2/2)
Head 2 (5/440) (2/2)
Head mesenchyme 2 (1/3) (2/2)
Heart 2 (1/440) (2/2)
Heart ventricle 2 (1/3) (2/2)
Hindbrain 2 (5/440) (2/2)
Hindlimb 2 (1/440) (2/2)
Humerus pre-cartilage condensation 2 Image Only (2/2)
Inner ear 2 Image Only (2/2)
Intestine 2 (2/2)
Liver 2 (1/440) (2/2)
Lower leg 2 (2/2)
Lung 2 (1/440) (2/2)
Mandibular process 2 (1/440) (2/2)
Maxillary process 2 (1/440) (2/2)
Mesonephros of female 2 Image Only (1/2)
Mesonephros of male 2 Image Only (1/2)
Metanephros 2 Image Only (2/2)
Midbrain 2 (1/440) (2/2)
Nasal septum 2 (2/2)
Nose 2 (1/5) (2/2)
Notochord 2 (2/2)
Oral cavity 2 (1/440) (2/2)
Outflow tract 2 (1/3) (2/2)
Pancreas 2 Image Only (2/2)
Pericardium 2 (1/2) (2/2)
Pharynx 2 Image Only (2/2)
Radius-ulna pre-cartilage condensation 2 Image Only (2/2)
Rib pre-cartilage condensation 2 (1/2) (2/2)
Skeleton 2 (1/5) (2/2)
Skin 2 (1/440) (2/2)
Spinal cord 2 (1/4) (2/2)
Stomach 2 Image Only (2/2)
Tail 2 (1/440) (2/2)
Tail somite 2 (1/440) (2/2)
Thoracic vertebral cartilage condensation 2 (1/2) (2/2)
Tongue 2 Image Only (2/2)
Trachea 2 Image Only (2/2)
Trunk mesenchyme 2 (1/3) (2/2)
Umbilical artery embryonic part 2 (2/2)
Umbilical vein embryonic part 2 (2/2)
Upper arm 2 (2/2)
Upper leg 2 (2/2)
Urinary system 2 Image Only (2/2)
Vibrissa 2 (2/2)


Associated Images

Phenotype associated images not available

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mthfd2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene