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Gene: Opn3 MGI:1338022

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Gene Summary

Name:
opsin 3
Synonyms:
Ecpn,  ERO,  encephalopsin,  panopsin

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Opn3em1(IMPC)Mbp HOM Early adult 0.00
increased basophil cell number Opn3em1(IMPC)Mbp HOM Early adult 3.88×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

57 Images

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X-ray

XRay Images Whole Body Lateral Orientation

19 Images

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Human diseases caused by Opn3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Opn3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fever, Familial Lifelong Persistent
Fever OMIM:228400
Chronic Myeloid Leukemia
Splenomegaly, Leukocytosis, Abnormal granulocyte morphology, Myeloproliferative disorder, Thrombo... ORPHA:521
Primary Erythromelalgia
Hypothermia ORPHA:90026
Riboflavin Deficiency
Hypothermia OMIM:615026
Neutropenia, Lethal Congenital, With Eosinophilia
Eosinophilia, Neutropenia OMIM:257100
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Kleine-Levin Syndrome
Fever, Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, A... ORPHA:33543
Obesity
Decreased resting energy expenditure OMIM:601665
Immunodeficiency 60 And Autoimmunity
Splenomegaly, Pancytopenia, Decreased proportion of memory B cells, Decreased basophil count OMIM:618394
Hereditary Central Diabetes Insipidus
Fever, Polydipsia ORPHA:30925
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Acute myeloid leukemia, Neutrophilia, Eosinophilia, Splenomegaly, Leukocytosis... ORPHA:98849
Coenzyme Q10 Deficiency, Primary, 5
Hypothermia OMIM:614654
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Central Diabetes Insipidus
Fever, Polydipsia, Anorexia ORPHA:178029
Idiopathic Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:95717
Nephronophthisis-Like Nephropathy 2
Polydipsia, Recurrent fever OMIM:619468
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Joint contracture, Inguinal hernia, Hypothermia OMIM:614498
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Obesity Due To Sim1 Deficiency
Polyphagia, Attention deficit hyperactivity disorder, Increased resting energy expenditure ORPHA:369873
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Meningococcal Meningitis
Fever, Hypothermia, Anorexia ORPHA:33475
Familial Cold Urticaria
Fever, Polydipsia ORPHA:47045
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Umbilical hernia, Hypothermia ORPHA:226313
Familial Thyroid Dyshormonogenesis
Umbilical hernia, Hypothermia ORPHA:95716
Menkes Disease
Hypothermia OMIM:309400
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Fever, Hip contracture, Abnormality of temperature regulation, Hypothermia, Elbow flexion contrac... OMIM:618493
Timothy Syndrome
Hypothermia OMIM:601005
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Huntington Disease
Aggressive behavior, Oral-pharyngeal dysphagia, Addictive alcohol use, Agitation, Compulsive beha... ORPHA:399
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Carnitine-Acylcarnitine Translocase Deficiency
Cyanosis, Hypothermia ORPHA:159
Congenital Enterovirus Infection
Fever, Hypothermia ORPHA:292
Ethylene Glycol Poisoning
Cyanosis, Addictive alcohol use, Hypothermia ORPHA:31826
Cystinosis
Fever, Polydipsia, Abnormal repetitive mannerisms ORPHA:213
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia, Unexplained fevers OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia, Unexplained fevers OMIM:304800
3-Hydroxy-3-Methylglutaric Aciduria
Fever, Hypothermia, Anorexia ORPHA:20
Acute Lung Injury
Fever, Addictive alcohol use, Hypoxemia ORPHA:178320
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Fever, Cyanosis, Hypothermia, Aggressive behavior, Self-injurious behavior, Compulsive behaviors,... ORPHA:293987
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Flexion contracture, Hypothermia, Dysphagia ORPHA:99027
Genetic Transient Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:226316
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use, Abnormality of connective tissue ORPHA:399180
Isolated Thyroid-Stimulating Hormone Deficiency
Umbilical hernia, Hypothermia, Attention deficit hyperactivity disorder ORPHA:90674
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Aromatic L-Amino Acid Decarboxylase Deficiency
Temperature instability, Tongue thrusting, Intermittent hypothermia OMIM:608643
Nephrogenic Diabetes Insipidus
Fever, Polydipsia, Anorexia ORPHA:223
Alexander Disease
Self-injurious behavior, Hypothermia, Dysphagia ORPHA:58
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia ORPHA:26793
Hereditary Sensory And Autonomic Neuropathy Type 4
Nail-biting, Fasciitis, Hyperactivity, Unexplained fevers, Impulsivity, Hypothermia, Corneal scar... ORPHA:642
Neuroleptic Malignant Syndrome
Fever, Agitation, Hypothermia, Dysphagia ORPHA:94093
Hypothyroidism Due To Tsh Receptor Mutations
Umbilical hernia, Hypothermia ORPHA:90673
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Flexion contracture, Hypothermia, Aggressive behavior ORPHA:17
Ochoa Syndrome
Polydipsia ORPHA:2704
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
Occipital Horn Syndrome
Inguinal hernia, Femoral hernia, Scarring, Hypothermia, Hiatus hernia, Atypical scarring of skin,... ORPHA:198
Teratoma, Pineal
Polydipsia OMIM:273120
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Pediatric-Onset Graves Disease
Hyperactivity, Polydipsia, Polyphagia ORPHA:525731
Mitochondrial Dna-Associated Leigh Syndrome
Fever, Hypothermia, Dysphagia ORPHA:255210
Marchiafava-Bignami Disease
Fever, Addictive alcohol use, Aggressive behavior ORPHA:221074
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Whipple Disease
Fever, Polydipsia, Anorexia ORPHA:3452
East Syndrome
Polydipsia, Salt craving ORPHA:199343
Menkes Disease
Inguinal hernia, Hypothermia, Atypical scarring of skin, Hernia, Umbilical hernia, Chondrocalcinosis ORPHA:565
Gitelman Syndrome
Polydipsia, Salt craving, Recurrent fever, Chondrocalcinosis OMIM:263800
Brain-Lung-Thyroid Syndrome
Hyperactivity, Abnormal eating behavior, Abnormal drinking behavior, Compulsive behaviors, Unexpl... ORPHA:209905
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Staphylococcal Necrotizing Pneumonia
Fever, Addictive alcohol use, Hypoxemia ORPHA:36238
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Helix Syndrome
Polydipsia, Heat intolerance OMIM:617671
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Isolated Osteopoikilosis
Keloids, Addictive alcohol use ORPHA:166119
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia ORPHA:79282
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia ORPHA:369929
Herpes Simplex Virus Encephalitis
Fever, Addictive alcohol use ORPHA:1930
Nephronophthisis 4
Polydipsia OMIM:606966
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Marburg Hemorrhagic Fever
Fever, Hypothermia, Anorexia, Aggressive behavior ORPHA:99826
Methanol Poisoning
Addictive alcohol use ORPHA:31825
Hyperparathyroidism-Jaw Tumor Syndrome
Lipoma, Polydipsia, Chondrocalcinosis, Dysphagia ORPHA:99880
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Oligomeganephronia
Polydipsia, Congenital diaphragmatic hernia ORPHA:2260
Nephronophthisis 1
Polydipsia OMIM:256100
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Umbilical hernia, Hypothermia ORPHA:226307
Rabson-Mendenhall Syndrome
Reduced subcutaneous adipose tissue, Polydipsia ORPHA:769
Parathyroid Carcinoma
Lipoma, Polydipsia, Chondrocalcinosis, Dysphagia ORPHA:143
Nephronophthisis 3
Polydipsia OMIM:604387
Hypothyroidism, Congenital, Nongoitrous, 2
Umbilical hernia, Hypothermia OMIM:218700
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving OMIM:612780
Acute Promyelocytic Leukemia
Fever, Addictive alcohol use, Anorexia ORPHA:520
Nephronophthisis 11
Polydipsia OMIM:613550
Renal Hypoplasia
Polydipsia ORPHA:93101
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Uterine prolapse, Hypothermia, Stereotypical hand wringing, Dysphagia ORPHA:438213
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Erdheim-Chester Disease
Fever, Polydipsia ORPHA:35687
Panhypophysitis
Polydipsia ORPHA:95513
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Limb joint contracture, Decreased resting energy expenditure, Achilles tendon contracture, Cornea... ORPHA:404454
Sarcoidosis
Fever, Scarring, Hypothermia ORPHA:797
Porphyria Cutanea Tarda
Addictive alcohol use, Scarring, Corneal scarring ORPHA:101330
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Bartter Syndrome, Type 2, Antenatal
Fever, Polydipsia, Chondrocalcinosis OMIM:241200
Acquired Aneurysmal Subarachnoid Hemorrhage
Addictive alcohol use ORPHA:90065
Gitelman Syndrome
Polydipsia, Salt craving, Chondrocalcinosis ORPHA:358
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Wolfram Syndrome
Polydipsia ORPHA:3463
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Cystinosis, Nephropathic
Polydipsia, Dysphagia, Oral-pharyngeal dysphagia OMIM:219800
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Proximal Renal Tubular Acidosis
Polydipsia, Enamel hypomineralization ORPHA:47159
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia OMIM:602522
Cirrhotic Cardiomyopathy
Addictive alcohol use ORPHA:57777
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Opn3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Opn3.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2. American journal of respiratory cell and molecular biology (January 2021) Opn3tm2b(EUCOMM)Wtsi PMC7780995
Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model. eNeuro (September 2020) Opn3tm2b(EUCOMM)Wtsi PMC7477952
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea. Investigative ophthalmology & visual science (June 2020) Opn3tm2b(EUCOMM)Wtsi PMC7415322
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell reports (January 2020) Opn3tm2a(EUCOMM)Wtsi PMC7341981
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proceedings of the National Academy of Sciences of the United States of America (September 2015) Opn3tm2a(EUCOMM)Wtsi Opn3tm2b(EUCOMM)Wtsi PMC4620855

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MGI Allele Allele Type Produced
Opn3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Opn3em1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Opn3tm40432(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Opn3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Opn3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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