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Gene: Arhgap31 MGI:1333857

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Gene Summary

Name:
Rho GTPase activating protein 31
Synonyms:
CdGAP

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased prepulse inhibition Arhgap31em1(IMPC)Bay HET Early adult 1.61×10-09
edema Arhgap31em1(IMPC)Bay HOM E15.5 0.00
preweaning lethality, incomplete penetrance Arhgap31em1(IMPC)Bay HOM   Early adult 0.00
hemorrhage Arhgap31em1(IMPC)Bay HOM E15.5 0.00
abnormal embryo size Arhgap31em1(IMPC)Bay HET E18.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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MicroCT E14.5-E15.5

Embryo reconstruction

6 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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MicroCT E18.5

Embryo reconstruction

1 Images

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Human diseases caused by Arhgap31 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Arhgap31 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Alopecia, Portal hypertension, Congenital hepatic fibrosis, Cirrhosi... ORPHA:974
Adams-Oliver Syndrome 1
Hypertension, Aortic valve stenosis, Pulmonary arterial hypertension, Pulmonic stenosis OMIM:100300

The table below shows human diseases predicted to be associated to Arhgap31 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lipedema
Edema OMIM:614103
Angioedema, Hereditary, 6
Facial edema, Angioedema, Edema of the dorsum of hands OMIM:619363
Pulmonary Edema Of Mountaineers, Susceptibility To
Elevated pulmonary artery pressure, Edema, Pulmonary edema OMIM:178400
Kaposi Sarcoma, Susceptibility To
Edema OMIM:148000
Lymphatic Malformation 11
Pedal edema, Lymphedema OMIM:619401
Lymphedema And Cerebral Arteriovenous Anomaly
Pulmonary arterial hypertension, Lymphedema OMIM:152900
Preeclampsia/Eclampsia 1
Hypertension, Edema OMIM:189800
Edema, Familial Idiopathic, Prepubertal
Edema OMIM:129840
Lymphatic Malformation 2
Lymphedema OMIM:611944
Macular Dystrophy, Dominant Cystoid
Cystoid macular edema, Edema OMIM:153880
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pericardial effusion, Pleural effusion, Generalized edema OMIM:618773
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
Mastocytosis, Cutaneous
Edema, Telangiectasia macularis eruptiva perstans OMIM:154800
White Sponge Nevus 2
Edema OMIM:615785
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Facial edema, Pericardial effusion, Increased nucha... OMIM:617300
Lymphatic Malformation 10
Lymphedema OMIM:619369
Congenital Enterocyte Heparan Sulfate Deficiency
Hematochezia, Edema, Dehydration ORPHA:103910
Deafness, Unilateral, With Delayed Endolymphatic Hydrops
Edema OMIM:612097
Lymphangiectasia, Pulmonary, Congenital
Palpebral edema, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Chylous ascites,... OMIM:265300
Corneal Dystrophy, Fuchs Endothelial, 2
Edema OMIM:610158
Aneurysm Of Sinus Of Valsalva
Aortic regurgitation, Congestive heart failure, Heart murmur, Edema ORPHA:1054
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Alopecia, Portal hypertension, Congenital hepatic fibrosis, Cirrhosi... ORPHA:974
Adams-Oliver Syndrome 1
Hypertension, Aortic valve stenosis, Pulmonary arterial hypertension, Pulmonic stenosis OMIM:100300

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arhgap31

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arhgap31.

No publications found that use IMPC mice or data for Arhgap31.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Arhgap31tm41948(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Arhgap31em1(IMPC)Bay Exon Deletion Mice
Arhgap31tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgap31tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Arhgap31tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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