Gene: Epc2

Name enhancer of polycomb homolog 2

Synonyms D2Ertd694e

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1e
phenotype data available

Links MGI:1278321   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Epc2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Epc2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Epc2tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased body weight Epc2tm1e(EUCOMM)Wtsi HET Male postnatal 2.11E-12
cataract Epc2tm1b(EUCOMM)Wtsi HET Male postnatal 5.01E-8
decreased IgG2b level Epc2tm1a(EUCOMM)Wtsi HOM Male postnatal 4.5E-7
abnormal lens morphology Epc2tm1b(EUCOMM)Wtsi HET Female Male postnatal 1.64E-6
decreased lactate dehydrogenase level Epc2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 6.24E-6
abnormal retinal blood vessel morphology Epc2tm1b(EUCOMM)Wtsi HET Male postnatal 9.93E-6
thrombocytopenia Epc2tm1a(EUCOMM)Wtsi HOM Male postnatal 1.23E-5
increased respiratory quotient Epc2tm1b(EUCOMM)Wtsi HET Female Male postnatal 1.83E-5
abnormal vertebral arch morphology Epc2tm1e(EUCOMM)Wtsi HET Female postnatal 4.47E-5
increased circulating alkaline phosphatase level Epc2tm1a(EUCOMM)Wtsi HOM Male postnatal 6.33E-5
decreased cardiac stroke volume Epc2tm1b(EUCOMM)Wtsi HET Female Male postnatal 7.03E-5

Download data as: TSV XLS



Expression

Secondary lacZ Expression Data
trunk (6)
  • Epc2tm1e(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    HEART, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    STOMACH, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI

show all 6 images

nervous system (4)
  • Epc2tm1e(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
reproductive system (2)
  • Epc2tm1e(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    UTERUS, HET, Female, WTSI
cardiovascular system (1)
  • Epc2tm1e(EUCOMM)Wtsi
    HEART, HET, Female, WTSI
digestive system (1)
  • Epc2tm1e(EUCOMM)Wtsi
    STOMACH, HET, Female, WTSI
endocrine system (1)
  • Epc2tm1e(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
set of connective tissues (1)
  • Epc2tm1e(EUCOMM)Wtsi
    CARTILAGE TISSUE, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
Legacy Phenotype Associated Images
Xray (189)
  • Epc2tm1e(EUCOMM)Wtsi
    HEAD, WT, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    HEAD, WT, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    TRUNK, HET, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    HEAD, HET, Male, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    HET, Male, WTSI

show all 189 images

Tail Epidermis Wholemount (3)
  • Epc2tm1e(EUCOMM)Wtsi
    HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    HET, Female, WTSI
  • Epc2tm1e(EUCOMM)Wtsi
    WT, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Epc2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Epc2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Epc2tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Epc2tm34341(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Epc2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele
Vector
Gene