Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cldn5 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Granulomas, Congenital Cerebral | Neonatal death | OMIM:306300 | |
Genitourinary Tract Anomalies | Neonatal death | OMIM:305690 | |
Pulmonary Hypoplasia, Primary | Neonatal death | OMIM:265430 | |
Hernia, Anterior Diaphragmatic | Neonatal death | OMIM:306950 | |
Epidermolysis Bullosa With Diaphragmatic Hernia | Neonatal death | OMIM:226735 | |
Mitochondrial Complex I Deficiency, Nuclear Type 30 | Neonatal death, Congestive heart failure | OMIM:301021 | |
Cardiomyopathy, Dilated, 2G | Aortic regurgitation, Tachycardia, Tricuspid regurgitation, Cerebral hemorrhage, Dilated cardiomy... | OMIM:619897 | |
Neutropenia, Lethal Congenital, With Eosinophilia | Neonatal death | OMIM:257100 | |
Cardiomyopathy, Dilated, 2H | Neonatal death, Reduced left ventricular ejection fraction | OMIM:620203 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cldn5.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. | eLife (September 2020) | Cldn5tm1a(EUCOMM)Wtsi | PMC7478896 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Cldn5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Cldn5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
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