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Gene: Cbx7 MGI:1196439

Gene Summary

Name:

chromobox 7

Synonyms:

1600014J01Rik, D15Ertd417e

Order Alleles

IMPC Data Collections

Body Weight Measurements
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

No results meet the p-value threshold

Select physiological systems to view:

Viewing: all phenotypes

Select physiological systems to view:

Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

Cbx7^{tm1a(KOMP)Wtsi}
body, WT, Male, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
head, WT, Male, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
body, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
head, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
body, WT, Male, WTSI

View all 83 images

Cbx7^{tm1a(KOMP)Wtsi}
back skin, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
back skin, WT, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
back skin, HOM, Female, WTSI

View all 6 images

Cbx7^{tm1a(KOMP)Wtsi}
abnormal sebaceous gland morphology, HOM, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
tail skin, WT, Female, WTSI

Cbx7^{tm1a(KOMP)Wtsi}
abnormal sebaceous gland morphology, HOM, Female, WTSI

Human diseases caused by Cbx7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Cbx7 (0 diseases)
Human diseases predicted to be associated with Cbx7 (74 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cbx7 by phenotypic similarity.

Disease	Matching phenotypes	Source
Colorectal Cancer, Susceptibility To, 12	Carcinoma	OMIM:615083
Tumor Predisposition Syndrome 1	Uveal melanoma, Renal cell carcinoma, Cutaneous melanoma, Malignant mesothelioma, Lung adenocarci...	OMIM:614327
Lung Cancer	Alveolar cell carcinoma, Lung adenocarcinoma, Non-small cell lung carcinoma	OMIM:211980
Reticulum Cell Sarcoma	Neoplasm, Sarcoma	OMIM:267730
Tumor Predisposition Syndrome 4	Glioma, Meningioma, Breast carcinoma, Sarcoma	OMIM:609265
Li-Fraumeni Syndrome	Neoplasm of the pancreas, Adrenocortical carcinoma, Soft tissue sarcoma, Breast carcinoma, Acute ...	OMIM:151623
Ewing Sarcoma	Ewing sarcoma	OMIM:612219
Melanoma-Pancreatic Cancer Syndrome	Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano...	OMIM:606719
Alveolar Soft Part Sarcoma	Alveolar soft part sarcoma	OMIM:606243
Sarcoma, Synovial	Synovial sarcoma	OMIM:300813
Epidermodysplasia Verruciformis, Susceptibility To, 3	Basal cell carcinoma, Verrucae, Squamous cell carcinoma	OMIM:618267
Squamous Cell Carcinoma, Head And Neck	Squamous cell carcinoma	OMIM:275355
Nut Midline Carcinoma	Oropharyngeal squamous cell carcinoma, Pancreatoblastoma, Squamous cell carcinoma, Neoplasm, Panc...	ORPHA:443167
Disseminated Superficial Actinic Porokeratosis	Squamous cell carcinoma	ORPHA:79152
Cheilitis Glandularis	Neoplasm, Squamous cell carcinoma	ORPHA:1221
Familial Adenomatous Polyposis 1	Astrocytoma, Adrenocortical carcinoma, Fibroadenoma of the breast, Medulloblastoma, Desmoid tumor...	OMIM:175100
Bazex Syndrome	Neoplasm, Lung adenocarcinoma, Liposarcoma	ORPHA:166113
Acquired Ichthyosis	Neoplasm, Lymphoma, Multiple myeloma, Sarcoma	ORPHA:454
Multiple Endocrine Neoplasia, Type Iv	Pancreatic endocrine tumor, Pituitary adenoma, Carcinoma, Parathyroid adenoma, Renal angiomyolipo...	OMIM:610755
Hyperkeratosis Lenticularis Perstans	Basal cell carcinoma, Squamous cell carcinoma	ORPHA:409
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease	Squamous cell carcinoma	OMIM:613736
Maffucci Syndrome	Neoplasm of the adrenal cortex, Chondrosarcoma, Astrocytoma, Hemangiomatosis, Neoplasm of the par...	ORPHA:163634
Palmoplantar Carcinoma, Multiple Self-Healing	Carcinoma, Squamous cell carcinoma	OMIM:615225
Oncogenic Osteomalacia	Neoplasm of the skeletal system, Neoplasm of head and neck, Neurofibroma, Carcinoma, Giant cell t...	ORPHA:352540
Schöpf-Schulz-Passarge Syndrome	Ovarian neoplasm, Basal cell carcinoma, Squamous cell carcinoma	ORPHA:50944
Ollier Disease	Chondrosarcoma, Visceral angiomatosis, Multiple enchondromatosis, Neoplasm, Hemangioma, Sarcoma	ORPHA:296
Nthl1-Related Attenuated Familial Adenomatous Polyposis	Endometrial carcinoma, Pancreatic adenocarcinoma, Seborrheic keratosis, Breast carcinoma, Squamou...	ORPHA:454840
Opsoclonus-Myoclonus Syndrome	Ovarian teratoma, Small cell lung carcinoma, Breast carcinoma, Neoplasm of the lung, Melanoma, Ne...	ORPHA:1183
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease	Elevated hepatic transaminase, Acute myeloid leukemia, B-cell lymphoma, Myelodysplasia, Hematolog...	ORPHA:158057
Paraneoplastic Pemphigus	B-cell lymphoma, Thymoma, Sarcoma	ORPHA:63455
Fanconi Renotubular Syndrome 5	Lung adenocarcinoma	OMIM:618913
Xeroderma Pigmentosum Variant	Melanoma, Basal cell carcinoma, Squamous cell carcinoma	ORPHA:90342
Mast Cell Sarcoma	Hepatomegaly, Sarcoma	ORPHA:66661
Cowden Syndrome 1	Fibroadenoma of the breast, Breast carcinoma, Carcinoma, Hamartomatous polyposis, Meningioma, Thy...	OMIM:158350
Punctate Palmoplantar Keratoderma Type 1	Pancreatic adenocarcinoma, Brain neoplasm, Neoplasm of the skeletal system, Esophageal neoplasm, ...	ORPHA:79501
Large Congenital Melanocytic Nevus	Rhabdomyosarcoma, Neoplasm, Neoplasm of the skin, Cutaneous melanoma, Sarcoma	ORPHA:626
Schopf-Schulz-Passarge Syndrome	Basal cell carcinoma, Poroma, Apocrine hidrocystoma, Squamous cell carcinoma	OMIM:224750
Junctional Epidermolysis Bullosa Inversa	Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma	ORPHA:79405
Cancer-Associated Retinopathy	Neoplasm of the pancreas, Pancreatic adenocarcinoma, Testicular neoplasm, Hematological neoplasm,...	ORPHA:71505
Legius Syndrome	Acute monocytic leukemia, Non-small cell lung carcinoma, Neurofibroma, Desmoid tumors, Ovarian ne...	ORPHA:137605
Liposarcoma	Sarcoma	ORPHA:69078
Asbestos Intoxication	Malignant mesothelioma, Lung adenocarcinoma	ORPHA:2302
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal	Laryngeal carcinoma, Carcinoma	OMIM:610644
Late-Onset Junctional Epidermolysis Bullosa	Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma	ORPHA:79406
Combined Immunodeficiency Due To Dock8 Deficiency	Squamous cell carcinoma of the vulva, Verrucae, Squamous cell carcinoma	ORPHA:217390
Adrenocortical Carcinoma	Adrenocortical carcinoma, Increased body weight, Lung adenocarcinoma	ORPHA:1501
Xeroderma Pigmentosum, Complementation Group F	Seborrheic keratosis, Keratoacanthoma, Squamous cell carcinoma, Basal cell carcinoma, Neoplasm of...	OMIM:278760
Self-Improving Dystrophic Epidermolysis Bullosa	Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma	ORPHA:79411
Gardner Syndrome	Neoplasm of the pancreas, Brain neoplasm, Astrocytoma, Adrenocortical carcinoma, Pilomatrixoma, M...	ORPHA:79665
Desmoplastic Small Round Cell Tumor	Neoplasm of the pancreas, Hepatomegaly, Testicular neoplasm, Ovarian neoplasm, Neoplasm of the ce...	ORPHA:83469
Lambert-Eaton Myasthenic Syndrome	Small cell lung carcinoma	ORPHA:43393
Oral Submucous Fibrosis	Oropharyngeal squamous cell carcinoma	ORPHA:357154
Necrobiosis Lipoidica	Squamous cell carcinoma	ORPHA:542592
Epidermodysplasia Verruciformis	Verrucae, Squamous cell carcinoma	ORPHA:302
Ichthyosis, Hystrix-Like, With Deafness	Squamous cell carcinoma	OMIM:602540
Werner Syndrome	Renal neoplasm, Acral lentiginous melanoma, Breast carcinoma, Squamous cell carcinoma, Neoplasm o...	ORPHA:902
Familial Adenomatous Polyposis	Brain neoplasm, Astrocytoma, Soft tissue neoplasm, Angiofibromas, Papillary thyroid carcinoma, Ad...	ORPHA:733
Aicardi Syndrome	Teratoma, Carcinoma, Lipoma, Hepatoblastoma, Metastatic angiosarcoma, Hemangioma	OMIM:304050
Xeroderma Pigmentosum, Variant Type	Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma	OMIM:278750
Turcot Syndrome With Polyposis	Glioblastoma multiforme, Brain neoplasm, Astrocytoma, Soft tissue neoplasm, Glioma, Pilomatrixoma...	ORPHA:99818
Fanconi Anemia, Complementation Group E	Leukemia, Prolonged G2 phase of cell cycle	OMIM:600901
Recessive Dystrophic Epidermolysis Bullosa Inversa	Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma	ORPHA:79409
Fanconi Anemia, Complementation Group A	Leukemia, Prolonged G2 phase of cell cycle	OMIM:227650
Recurrent Respiratory Papillomatosis	Squamous cell carcinoma	ORPHA:60032
Dyskeratosis Congenita, X-Linked	Acute myeloid leukemia, Oropharyngeal squamous cell carcinoma, Myelodysplasia, Hodgkin lymphoma, ...	OMIM:305000
Cushing Syndrome Due To Ectopic Acth Secretion	Pancreatic adenocarcinoma, Pancreatoblastoma, Pituitary corticotropic cell adenoma, Neoplasm of t...	ORPHA:99889
Fanconi Anemia, Complementation Group C	Leukemia, Prolonged G2 phase of cell cycle	OMIM:227645
Dermatomyositis	Gastrointestinal stroma tumor, Lymphoma, Breast carcinoma, Neoplasm, Lung adenocarcinoma	ORPHA:221
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma	Squamous cell carcinoma	OMIM:618373
Fanconi Anemia, Complementation Group D2	Patent ductus arteriosus, Leukemia, Prolonged G2 phase of cell cycle	OMIM:227646
Retinoblastoma	Lymphoma, Retinoblastoma, Leukemia, Ewing sarcoma, Pinealoma, Osteosarcoma	OMIM:180200
Papillon-Lefèvre Syndrome	Melanoma, Liver abscess, Neoplasm of the skin, Squamous cell carcinoma	ORPHA:678
Fanconi Anemia, Complementation Group P	Squamous cell carcinoma	OMIM:613951
Sotos Syndrome	Sacrococcygeal teratoma, Tall stature, Astrocytoma, Small cell lung carcinoma, Patent ductus arte...	ORPHA:821

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cbx7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cbx7.

There are 6 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.	Circulation (May 2023)	Cbx7^{tm1c(KOMP)Wtsi} Cbx7^{tm1a(KOMP)Wtsi}	37158107
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Cbx7^{tm1a(KOMP)Wtsi}	PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PLoS biology (April 2019)	Cbx7^{tm1a(KOMP)Wtsi}	PMC6459510
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.	Nature communications (April 2014)	Cbx7^{tm1a(KOMP)Wtsi}	PMC3996542
KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes.	Molecular and cellular biology (March 2014)	Cbx7^{tm1a(KOMP)Wtsi}	PMC4019052
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.	Cell (July 2013)	Cbx7^{tm1a(KOMP)Wtsi}	PMC3717207

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Cbx7^{tm1e(KOMP)Wtsi}	Targeted, non-conditional allele	ES Cells
Cbx7^{tm1a(KOMP)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Cbx7^{tm42029(pL1L2_GT2_DelLacZ_bsd)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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