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Gene: Tnpo3 MGI:1196412

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
transportin 3
Synonyms:
C430013M08Rik,  D6Ertd313e,  5730544L10Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tnpo3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tnpo3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Primary Biliary Cholangitis
ORPHA:186
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2
OMIM:608423

The table below shows human diseases predicted to be associated to Tnpo3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Primary Biliary Cholangitis
ORPHA:186
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2
OMIM:608423

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tnpo3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tnpo3.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells. Nature communications (June 2023) Tnpo3tm1a(KOMP)Wtsi PMC10282035
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Genes & development (August 2022) Tnpo3tm1c(KOMP)Wtsi 36167471
Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell reports (November 2016) Tnpo3tm1c(KOMP)Wtsi Tnpo3tm1a(KOMP)Wtsi Tnpo3tm1d(KOMP)Wtsi PMC5149563

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tnpo3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Tnpo3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tnpo3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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