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Gene: Atp2a3 MGI:1194503

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
ATPase, Ca++ transporting, ubiquitous
Synonyms:
Serca3

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Atp2a3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Atp2a3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Thomsen And Becker Disease
Myotonia ORPHA:614
Myotonia Congenita, Autosomal Dominant
Handgrip myotonia, Myotonia, Percussion myotonia, Myotonia with warm-up phenomenon, EMG: myotonic... OMIM:160800
Rippling Muscle Disease 1
Percussion-induced rapid rolling muscle contractions, Muscle mounding OMIM:600332
Proximal Myotonic Myopathy
Myotonia ORPHA:606
Paramyotonia Congenita Of Von Eulenburg
Handgrip myotonia, Myotonia of the upper limb, Myotonia, Myotonia of the face, Cold-sensitive myo... ORPHA:684
Normokalemic Periodic Paralysis
Percussion myotonia OMIM:170600
Myotonia Congenita, Autosomal Recessive
Percussion myotonia, Myotonia with warm-up phenomenon, Myotonia, EMG: myotonic runs OMIM:255700
Myopathy, Granulovacuolar Lobular, With Electrical Myotonia
Myotonia OMIM:254950
Paramyotonia Congenita
Percussion myotonia, Handgrip myotonia, Paradoxical myotonia OMIM:168300
Muscular Dystrophy, Barnes Type
Myotonia OMIM:158800
Rippling Muscle Disease 2
Percussion-induced rapid rolling muscle contractions, Muscle mounding OMIM:606072
Brody Disease
Percussion myotonia, Myotonia OMIM:601003
Hyperkalemic Periodic Paralysis
Myotonia OMIM:170500
Myotonia, Potassium-Aggravated
Percussion myotonia, Handgrip myotonia, Myotonia OMIM:608390
Myotonia Fluctuans
Handgrip myotonia, Myotonia of the upper limb, Myotonia of the lower limb, Cold-sensitive myotoni... ORPHA:99734
Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency
Myotonia ORPHA:371
Hypokalemic Periodic Paralysis, Type 1
Myotonia OMIM:170400
Myofibrillar Myopathy 10
Percussion myotonia, Prolonged QTc interval, Increased QRS voltage OMIM:619040
Hypokalemic Periodic Paralysis
Impaired myocardial contractility, Myotonia ORPHA:681
Myotonia With Skeletal Abnormalities And Mental Retardation
Myotonia OMIM:255710
Distal Myopathy, Tateyama Type
Percussion-induced rapid rolling muscle contractions, Palpitations ORPHA:488650
Acetazolamide-Responsive Myotonia
Myotonia ORPHA:99736
Dnajb6-Related Limb-Girdle Muscular Dystrophy D1
Percussion myotonia ORPHA:34516
Myotonic Dystrophy 1
Atrial flutter, Myotonia, First degree atrioventricular block, Atrial fibrillation OMIM:160900
Myotonic Dystrophy 2
Handgrip myotonia, Tachycardia, Myotonia, Premature ventricular contraction, Right bundle branch ... OMIM:602668
Myopathy, X-Linked, With Excessive Autophagy
Myotonia OMIM:310440
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy
Myotonia ORPHA:209335
Autosomal Recessive Axonal Neuropathy With Neuromyotonia
Handgrip myotonia, Percussion-induced rapid rolling muscle contractions, Myotonia ORPHA:324442
Episodic Ataxia, Type 2
Myotonia OMIM:108500
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy
Ventricular escape rhythm, Myotonia, Sudden cardiac death, Supraventricular arrhythmia, Dilated c... ORPHA:98855
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy
Ventricular escape rhythm, Myotonia, Sudden cardiac death, Supraventricular arrhythmia, Dilated c... ORPHA:98853
Emery-Dreifuss Muscular Dystrophy
Ventricular escape rhythm, Myotonia, Sudden cardiac death, Supraventricular arrhythmia, Dilated c... ORPHA:261
Myotonia Permanens
Myotonia ORPHA:99735
Hyperkalemic Periodic Paralysis
Congestive heart failure, Arrhythmia, Myotonia ORPHA:682
X-Linked Emery-Dreifuss Muscular Dystrophy
Ventricular escape rhythm, Myotonia, Sudden cardiac death, Supraventricular arrhythmia, Atriovent... ORPHA:98863
Episodic Ataxia Type 1
Myotonia ORPHA:37612
Congenital-Onset Steinert Myotonic Dystrophy
Bundle branch block, Myotonia, First degree atrioventricular block ORPHA:589821
Zebra Body Myopathy
Handgrip myotonia ORPHA:97240
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Myotonia ORPHA:391307
Gamma-Sarcoglycan-Related Limb-Girdle Muscular Dystrophy R5
Left ventricular systolic dysfunction, EMG: myotonic runs ORPHA:353
Spastic Paraplegia 79B, Autosomal Recessive
Myotonia OMIM:615491
Richieri Costa-Da Silva Syndrome
Handgrip myotonia, Myotonia of the upper limb ORPHA:3101
Thyrotoxic Periodic Paralysis
Prolonged QT interval, Myotonia, Shortened PR interval, Impaired myocardial contractility, Second... ORPHA:79102
Schwartz-Jampel Syndrome, Type 1
Percussion myotonia OMIM:255800
Mitochondrial Complex Iv Deficiency, Nuclear Type 23
Percussion myotonia OMIM:620275
Stuve-Wiedemann Syndrome 1
Pulmonary arterial hypertension, Myotonia OMIM:601559
Idiopathic Camptocormia
Myotonia ORPHA:1320
Schwartz-Jampel Syndrome
Pulmonary arterial hypertension, Arrhythmia, Myotonia ORPHA:800
Lipodystrophy, Congenital Generalized, Type 4
Prolonged QT interval, Tachycardia, Atrial fibrillation, Muscle mounding, Bradycardia OMIM:613327
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Handgrip myotonia ORPHA:438216
Anoctamin-5-Related Limb-Girdle Muscular Dystrophy R12
Cardiomyopathy, EMG: myotonic runs ORPHA:206549
Steinert Myotonic Dystrophy
Handgrip myotonia, Myotonia of the upper limb, Atrial fibrillation, Prolonged QRS complex, Left v... ORPHA:273

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atp2a3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atp2a3.

No publications found that use IMPC mice or data for Atp2a3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atp2a3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Atp2a3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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