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Gene: Myt1 MGI:1100535

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
myelin transcription factor 1
Synonyms:
NZF-2b,  Nztf2,  Nzf2,  NZF-2a

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Myt1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Myt1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death, Congenital diaphragmatic hernia OMIM:226735
Hernia, Anterior Diaphragmatic
Neonatal death, Congenital diaphragmatic hernia OMIM:306950
Lethal Congenital Contracture Syndrome 3
Neonatal death, Skeletal muscle atrophy, Multiple joint contractures, Arthrogryposis multiplex co... OMIM:611369
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Hyperinsulinemic Hypoglycemia, Familial, 2
Nesidioblastosis, Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 1
Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia OMIM:256450
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemia, Pancreatic islet-cell hyperplasia, Hyperinsulinemic hypoglycemia OMIM:610021
Diaphragmatic Hernia, Congenital
Congenital diaphragmatic hernia OMIM:142340
Diaphragmatic Hernia 3
Congenital diaphragmatic hernia OMIM:610187
Diabetes Mellitus, Ketosis-Prone
Beta-cell dysfunction, Diabetes mellitus OMIM:612227
Hyperinsulinemic Hypoglycemia, Familial, 6
Abnormality of the pancreatic islet cells, Hyperinsulinemic hypoglycemia OMIM:606762
Mahvash Disease
Recurrent pancreatitis, Type II diabetes mellitus, Pancreatic alpha-cell hyperplasia, Increased g... OMIM:619290
Congenital Myopathy 2B, Severe Infantile, Autosomal Recessive
Death in infancy, Nemaline bodies, Increased variability in muscle fiber diameter, Death in child... OMIM:620265
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Hereditary Continuous Muscle Fiber Activity
Congenital diaphragmatic hernia, Type 1 muscle fiber predominance ORPHA:972
Hjv Or Hamp-Related Hemochromatosis
Abnormality of endocrine pancreas physiology, Congenital hepatic fibrosis, Diabetes mellitus, Hyp... ORPHA:79230
Diaphragmatic Hernia 2
Agenesis of the diaphragm, Congenital diaphragmatic hernia OMIM:222400
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death, Hepatosplenomegaly OMIM:273680
Arthrogryposis Multiplex Congenita 6
Death in infancy, Increased variability in muscle fiber diameter, Death in childhood, Neonatal de... OMIM:619334
8p23.1 deletion syndrome
Congenital diaphragmatic hernia DECIPHER:39
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Microphthalmia, Syndromic 12
Neonatal death, Congenital diaphragmatic hernia OMIM:615524
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Hyperinsulinemic hypoglycemia, Hyperinsulinemia, Pancreatic islet-cell hyperplasia, Hyperhidrosis ORPHA:276608
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hepatomegaly, Episodic hyperhidrosis, Hyperinsulinemia, Type I diabetes mellitus, Hyperinsulinemi... ORPHA:276575
Isolated Anencephaly
Thymus hyperplasia, Congenital diaphragmatic hernia, Adrenal hypoplasia, Maternal diabetes ORPHA:563609
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Elevated circulating growth hormone concentration, Multiple pancreatic beta-cell adenomas, Increa... ORPHA:79644
Insulinoma
Abnormality of the pancreatic islet cells, Fasting hyperinsulinemia, Primary hyperparathyroidism,... ORPHA:97279
Cutis Laxa-Marfanoid Syndrome
Flexion contracture, Congenital diaphragmatic hernia ORPHA:171719
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hepatomegaly, Maternal diabetes, Episodic hyperhidrosis, Hyperinsulinemia, Type I diabetes mellit... ORPHA:276580
Cutis Laxa, Neonatal, With Marfanoid Phenotype
Congenital diaphragmatic hernia OMIM:614100
Congenital Diaphragmatic Hernia
Aplasia/Hypoplasia of the diaphragm, Congenital diaphragmatic hernia ORPHA:2140
Neuronal Intestinal Pseudoobstruction
Congenital diaphragmatic hernia ORPHA:99811
Distal 7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:261102
Hyperinsulinism Due To Ucp2 Deficiency
Hepatomegaly, Episodic hyperhidrosis, Hyperinsulinemic hypoglycemia, Excessive insulin response t... ORPHA:276556
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Neonatal death, Rhabdomyolysis OMIM:602199
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Congenital diaphragmatic hernia ORPHA:438134
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Abnormality of the diaphragm, Testicular atrophy, Congenital diaphragmatic hernia OMIM:601163
Fetal Encasement Syndrome
Congenital diaphragmatic hernia OMIM:613630
Diaphragmatic Defect-Limb Deficiency-Skull Defect Syndrome
Congenital diaphragmatic hernia ORPHA:2141
Donohue Syndrome
Skeletal muscle atrophy, Precocious puberty, Hyperinsulinemia, Cholestasis, Hepatic fibrosis, Pan... OMIM:246200
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Hepatic steatosis, Diabetes mellitus, Jaundice, Aplasia/Hypoplasia of the pancreas, Abnormality o... ORPHA:93111
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Hepatomegaly, Hyperinsulinemia, Hyperhidrosis, Pancreatic islet-cell hyperplasia, Hyperinsulinemi... ORPHA:263455
Greig Cephalopolysyndactyly Syndrome
Congenital diaphragmatic hernia ORPHA:380
Acrocallosal Syndrome
Congenital diaphragmatic hernia ORPHA:36
Congenital Unilateral Hypoplasia Of Depressor Anguli Oris
Congenital diaphragmatic hernia ORPHA:1166
Linear Skin Defects With Multiple Congenital Anomalies 2
Congenital diaphragmatic hernia OMIM:300887
Matthew-Wood Syndrome
Congenital diaphragmatic hernia, Annular pancreas, Abnormal spleen morphology, Aplasia/Hypoplasia... ORPHA:2470
Multicentric Carpotarsal Osteolysis Syndrome
Congenital diaphragmatic hernia OMIM:166300
Non-Syndromic Posterior Hypospadias
Abnormality of the endocrine system, Congenital diaphragmatic hernia, Androgen insufficiency ORPHA:95706
Serkal Syndrome
Abnormality of the adrenal glands, Congenital diaphragmatic hernia ORPHA:139466
Gillessen-Kaesbach-Nishimura Syndrome
Periportal fibrosis, Flexion contracture, Congenital diaphragmatic hernia OMIM:263210
Craniofrontonasal Dysplasia
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:1520
Intellectual Disability-Strabismus Syndrome
Decreased serum insulin-like growth factor 1, Decreased response to growth hormone stimulation te... ORPHA:363528
Cebalid Syndrome
Congenital diaphragmatic hernia OMIM:618774
Tonne-Kalscheuer Syndrome
Congenital diaphragmatic hernia OMIM:300978
Donnai-Barrow Syndrome
Congenital diaphragmatic hernia ORPHA:2143
Schisis Association
Congenital diaphragmatic hernia ORPHA:63862
15Q24 Microdeletion Syndrome
Decreased response to growth hormone stimulation test, Congenital diaphragmatic hernia ORPHA:94065
Perlman Syndrome
Hypoplasia of the abdominal wall musculature, Pancreatic islet-cell hyperplasia, Congenital diaph... OMIM:267000
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Death in infancy, Congenital diaphragmatic hernia ORPHA:1120
Xp22.13P22.2 Duplication Syndrome
Congenital diaphragmatic hernia ORPHA:284180
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus
Type I diabetes mellitus, Hepatomegaly, Insulin-resistant diabetes mellitus, Reduced pancreatic b... OMIM:226980
Proximal 16P11.2 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:370079
1Q41Q42 Microdeletion Syndrome
Hypergonadotropic hypogonadism, Congenital diaphragmatic hernia ORPHA:250999
Cooper-Jabs Syndrome
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:1488
Humerofemoral Hypoplasia With Radiotibial Ray Deficiency
Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:618022
13Q12.3 Microdeletion Syndrome
Congenital diaphragmatic hernia, Camptodactyly ORPHA:412035
Genitopalatocardiac Syndrome
Abnormal mesentery morphology, Abnormality of the gallbladder, Congenital diaphragmatic hernia ORPHA:2075
Axial Mesodermal Dysplasia Spectrum
Abnormality of the spleen, Abnormality of the liver, Congenital diaphragmatic hernia ORPHA:1834
Ferguson-Bonni Neurodevelopmental Syndrome
Congenital diaphragmatic hernia OMIM:619699
Emanuel Syndrome
Joint contracture, Torticollis, Congenital diaphragmatic hernia OMIM:609029
Simpson-Golabi-Behmel Syndrome
Hepatomegaly, Death in infancy, Camptodactyly of finger, Congenital diaphragmatic hernia, Splenom... ORPHA:373
Denys-Drash Syndrome
Neonatal death, Posterolateral diaphragmatic hernia, Congenital diaphragmatic hernia OMIM:194080
Greenberg Dysplasia
Hepatomegaly, Hepatic calcification, Hepatosplenomegaly, Stillbirth, Pancreatic islet-cell hyperp... OMIM:215140
Pericardial And Diaphragmatic Defect
Aplasia of the left hemidiaphragm, Congenital diaphragmatic hernia ORPHA:2847
Lowry-Maclean Syndrome
Abnormality of the abdominal organs, Congenital diaphragmatic hernia ORPHA:2409
Isolated Permanent Neonatal Diabetes Mellitus
Neonatal insulin-dependent diabetes mellitus, Lower-limb joint contracture, Arthrogryposis multip... ORPHA:99885
Emanuel Syndrome
Multiple joint contractures, Hypogonadism, Congenital diaphragmatic hernia ORPHA:96170
Microphthalmia, Syndromic 9
Congenital diaphragmatic hernia, Multilobulated spleen, Neonatal death, Diaphragmatic eventration... OMIM:601186
Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis
Congenital diaphragmatic hernia OMIM:606164
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome
Congenital diaphragmatic hernia ORPHA:2063
Halperin-Birk Syndrome
Flexion contracture, Congenital diaphragmatic hernia, Death in childhood OMIM:618651
Vacterl/Vater Association
Abnormality of the pancreas, Abnormality of the gallbladder, Congenital diaphragmatic hernia ORPHA:887
Zaki Syndrome
Congenital diaphragmatic hernia OMIM:619648
Trisomy 1Q
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:261344
Fetal Alcohol Syndrome
Congenital diaphragmatic hernia ORPHA:1915
Oculocerebrocutaneous Syndrome
Congenital diaphragmatic hernia ORPHA:1647
Autosomal Recessive Spondylocostal Dysostosis
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:2311
Donnai-Barrow Syndrome
Diaphragmatic eventration, Congenital diaphragmatic hernia OMIM:222448
Chromosome 1Q41-Q42 Deletion Syndrome
Congenital diaphragmatic hernia OMIM:612530
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
Adrenal gland agenesis, Congenital diaphragmatic hernia OMIM:611812
White-Sutton Syndrome
Facial hypotonia, Congenital diaphragmatic hernia OMIM:616364
Ataxia-Telangiectasia-Like Disorder 2
Joint contracture, Congenital diaphragmatic hernia OMIM:615919
Diamond-Blackfan Anemia 10
Congenital diaphragmatic hernia, Morgagni diaphragmatic hernia OMIM:613309
Tyrosinemia, Type I
Hepatomegaly, Splenomegaly, Pancreatic islet-cell hyperplasia, Cirrhosis, Hepatocellular carcinoma OMIM:276700
Mosaic Trisomy 1
Hepatic agenesis, Elbow flexion contracture, Camptodactyly of finger, Congenital diaphragmatic he... ORPHA:1692
2Q37 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:1001
Pentalogy Of Cantrell
Absent gallbladder, Congenital diaphragmatic hernia, Polysplenia ORPHA:1335
Multiple Pterygium Syndrome, Escobar Variant
Multiple joint contractures, Congenital diaphragmatic hernia, Weakness of facial musculature, Fle... OMIM:265000
Congenital Heart Defects And Skeletal Malformations Syndrome
Congenital diaphragmatic hernia, Camptodactyly OMIM:617602
Proximal 16P11.2 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:261197
Craniorachischisis
Congenital diaphragmatic hernia ORPHA:63260
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Neonatal insulin-dependent diabetes mellitus, Congenital diaphragmatic hernia, Biliary atresia, C... ORPHA:2255
8P23.1 Microdeletion Syndrome
Congenital diaphragmatic hernia ORPHA:251071
Acro-Renal-Mandibular Syndrome
Congenital diaphragmatic hernia ORPHA:958
Seckel Syndrome 9
Congenital diaphragmatic hernia OMIM:616777
Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart Defects
Left ventricular hypertrophy, Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:245600
Cutis Laxa, Autosomal Recessive, Type Ia
Congenital diaphragmatic hernia OMIM:219100
White-Sutton Syndrome
Facial hypotonia, Congenital diaphragmatic hernia ORPHA:468678
Beckwith-Wiedemann Syndrome
Hepatomegaly, Adrenocortical cytomegaly, Diastasis recti, Congenital diaphragmatic hernia, Rhabdo... ORPHA:116
Chromosome 15Q25 Deletion Syndrome
Congenital diaphragmatic hernia, Polysplenia OMIM:614294
Arterial Tortuosity Syndrome
Flexion contracture, Congenital diaphragmatic hernia OMIM:208050
Thakker-Donnai Syndrome
Congenital diaphragmatic hernia ORPHA:1780
Holoprosencephaly
Diabetes mellitus, Congenital diaphragmatic hernia, Abnormality of the spleen, Panhypopituitarism... ORPHA:2162
Focal Dermal Hypoplasia
Camptodactyly of finger, Diastasis recti, Congenital diaphragmatic hernia ORPHA:2092
Fryns Syndrome
Congenital diaphragmatic hernia ORPHA:2059
Pagod Syndrome
Abnormality of the spleen, Congenital diaphragmatic hernia, Death in infancy ORPHA:991
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
Congenital diaphragmatic hernia OMIM:614080
Heart Defects, Congenital, And Other Congenital Anomalies
Absent gallbladder, Diabetes mellitus, Congenital diaphragmatic hernia, Biliary atresia, Aplasia ... OMIM:600001
Simpson-Golabi-Behmel Syndrome, Type 1
Hepatomegaly, Facial hypotonia, Diastasis recti, Congenital diaphragmatic hernia, Splenomegaly, M... OMIM:312870
Trisomy 18
Camptodactyly of finger, Congenital diaphragmatic hernia ORPHA:3380
Hydrolethalus Syndrome 1
Accessory spleen, Stillbirth, Agenesis of the diaphragm, Adrenal gland dysgenesis OMIM:236680
Developmental Delay With Or Without Dysmorphic Facies And Autism
Congenital diaphragmatic hernia OMIM:618454
Oligomeganephronia
Congenital diaphragmatic hernia ORPHA:2260
7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia ORPHA:96121
Thoracoabdominal Syndrome
Congenital diaphragmatic hernia OMIM:313850
Cornelia De Lange Syndrome 1
Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:122470
Opitz Gbbb Syndrome
Thyroglossal cyst, Congenital diaphragmatic hernia ORPHA:2745
Craniofrontonasal Syndrome
Congenital diaphragmatic hernia OMIM:304110
Meacham Syndrome
Abnormality of the spleen, Congenital diaphragmatic hernia ORPHA:3097
Aymé-Gripp Syndrome
Congenital diaphragmatic hernia, Camptodactyly ORPHA:1272
Mycophenolate Mofetil Embryopathy
Congenital diaphragmatic hernia ORPHA:268249
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Congenital diaphragmatic hernia OMIM:616546
Wolf-Hirschhorn Syndrome
Abnormality of the gallbladder, Abdominal situs inversus, Congenital diaphragmatic hernia ORPHA:280
Kabuki Syndrome
Precocious puberty, Congenital diaphragmatic hernia ORPHA:2322
Tetraamelia Syndrome 1
Asplenia, Adrenal gland agenesis, Congenital diaphragmatic hernia OMIM:273395
Smith-Lemli-Opitz Syndrome
Abnormality of the gallbladder, Congenital diaphragmatic hernia ORPHA:818
Acrorenal-Mandibular Syndrome
Elbow flexion contracture, Congenital diaphragmatic hernia OMIM:200980
Poland Syndrome
Aplasia of the pectoralis major muscle, Abnormality of the liver, Diabetes mellitus, Congenital d... ORPHA:2911
Linear Skin Defects With Multiple Congenital Anomalies 1
Congenital diaphragmatic hernia OMIM:309801
Distal Deletion 15Q
Decreased serum insulin-like growth factor 1, Congenital diaphragmatic hernia ORPHA:1596
Acrofacial Dysostosis 1, Nager Type
Congenital diaphragmatic hernia OMIM:154400
Monosomy 9P
Congenital diaphragmatic hernia ORPHA:261112
C Syndrome
Death in infancy, Aplasia/Hypoplasia of the abdominal wall musculature, Congenital diaphragmatic ... ORPHA:1308
Mullegama-Klein-Martinez Syndrome
Facial palsy, Congenital diaphragmatic hernia OMIM:301022
Limb Body Wall Complex
Abnormality of the liver, Diastasis recti, Congenital diaphragmatic hernia ORPHA:2369
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Contracture of the proximal interphalangeal joint of the 3rd finger, Congenital diaphragmatic her... OMIM:301044
Iniencephaly
Arthrogryposis multiplex congenita, Congenital diaphragmatic hernia ORPHA:63259
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Congenital diaphragmatic hernia OMIM:617641
Diets-Jongmans Syndrome
Congenital diaphragmatic hernia OMIM:618846
Microphthalmia With Linear Skin Defects Syndrome
Congenital diaphragmatic hernia ORPHA:2556
Cutis Laxa, Autosomal Recessive, Type Ib
Congenital diaphragmatic hernia OMIM:614437
Cardiac-Urogenital Syndrome
Accessory spleen, Hepatopulmonary fusion, Congenital diaphragmatic hernia OMIM:618280
Witteveen-Kolk Syndrome
Type II diabetes mellitus, Congenital diaphragmatic hernia, Decreased response to growth hormone ... OMIM:613406
Focal Dermal Hypoplasia
Diastasis recti, Congenital diaphragmatic hernia OMIM:305600
Cardiospondylocarpofacial Syndrome
Congenital diaphragmatic hernia OMIM:157800
Cornelia De Lange Syndrome
Congenital diaphragmatic hernia, Delayed puberty ORPHA:199
Coffin-Siris Syndrome 1
Congenital diaphragmatic hernia OMIM:135900
Pallister-Killian Syndrome
Anhidrosis, Congenital diaphragmatic hernia, Flexion contracture, Hypohidrosis, Macroglossia, Sti... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myt1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myt1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Postnatal age-differential ASD-like transcriptomic, synaptic, and behavioral deficits in Myt1l-mutant mice. Cell reports (September 2022) Myt1ltm1a(EUCOMM)Wtsi 36130507
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Myt1ltm1a(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Myt1ltm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Myt1ltm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Myt1ltm1a(EUCOMM)Wtsi PMC5827107

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MGI Allele Allele Type Produced
Myt1tm299770(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Myt1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Myt1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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