Gene: Twf1

Order

Name twinfilin actin binding protein 1

Synonyms
  • actin monomer-binding protein
  • twinfilin
  • A6
  • Twinfilin-1
  • Ptk9

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1100520    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Twf1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Twf1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal skin condition Twf1tm1a(EUCOMM)Wtsi HOM Male postnatal 8.48E-8

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse reproductive system integumental system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (4)
  • Twf1tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
trunk (3)
  • Twf1tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
immune system (1)
  • Twf1tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
integumental system (1)
  • Twf1tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
reproductive system (1)
  • Twf1tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
urinary system (1)
  • Twf1tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (75)
  • Twf1tm1a(EUCOMM)Wtsi
    head, HOM, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    head, HOM, Male, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    forearm, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI

show all 75 images

Eye Morphology (6)
  • Twf1tm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    eye, cornea/lens fusion, corneal opacity, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, abnormal retinal pigmentation, HOM, Female, WTSI
  • Twf1tm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI

show all 6 images

Skin Histopathology (1)
  • Twf1tm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Twf1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Twf1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Twf1tm46454(L1L2_gt1)
Vector
Gene