Gene: Fgf10

Order

Name fibroblast growth factor 10

Synonyms
  • FGF-10
  • Gsfaey17
  • AEY17

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1c
phenotype data available

Links MGI:1099809    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Fgf10

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Fgf10 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Fgf10tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased circulating HDL cholesterol level Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 8.27E-9
decreased grip strength Fgf10tm1b(EUCOMM)Wtsi HET Female postnatal 7.45E-8
increased total body fat amount Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 5.06E-6
decreased spleen weight Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 4.83E-5
increased circulating cholesterol level Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 7.59E-5
decreased lean body mass Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 8.25E-5
decreased kidney weight Fgf10tm1b(EUCOMM)Wtsi HET Female Male postnatal 9.14E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562) (1/2)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No
Heart 2 No (3/562) (1/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (1/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (1/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    nervous system
    sensory organ
    reproductive system
    exocrine system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/440) (2/5)
Ear 2 (1/440) (1/5)
Embryo 2 (1/440) (5/5)
Eye 2 (1/440)
Foot 2 (1/5)
Forebrain 2 (1/440) (2/5)
Forelimb 2 (1/440)
Hand 2 (1/5)
Head 2 (5/440) (5/5)
Heart 2 (1/440) (1/5)
Hindbrain 2 (5/440) (1/5)
Hindlimb 2 (1/440)
Liver 2 (1/440) (1/5)
Lung 2 (1/440)
Mandibular process 2 (1/440) (1/5)
Maxillary process 2 (1/440) (1/5)
Midbrain 2 (1/440)
Oral cavity 2 (1/440)
Skin 2 (1/440)
Tail 2 (1/440)
Tail somite 2 (1/440)


Associated Images

Associated Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images
  • Adult LacZ: LacZ Images Wholemount
    12 Images
  • X-ray: XRay Images Dorso Ventral
    12 Images
  • Echo: M-Mode Images
    31 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Fgf10tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Fgf10tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fgf10tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene
Fgf10tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene