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Gene: Plk2 MGI:1099790

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
polo like kinase 2
Synonyms:
Snk

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plk2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Plk2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor, Abnormal bone structure ORPHA:46532
Placental Insufficiency
Abnormal umbilical cord blood vessel morphology, Proportionate short stature, Small placenta, Abn... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Short stature, Postnatal growth retardation, Osteoporosis, Congenital bilateral ptosis, Severe po... ORPHA:73272
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Osteoporosis, Pallor, Short stature ORPHA:2786
Dermatitis, Atopic
Dry skin, Conjunctivitis, Pallor, Facial erythema OMIM:603165
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Growth delay, Pallor, Ptosis OMIM:613561
Optic Atrophy 1
Pallor OMIM:165500
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Myopathic Ehlers-Danlos Syndrome
Multiple joint contractures, Foot joint contracture, Shoulder flexion contracture, Ankle flexion ... ORPHA:536516
Restrictive Dermopathy
Osteopenia, Multiple joint contractures, Premature delivery because of cervical insufficiency or ... ORPHA:1662
Congenital Heart Block
Premature birth, Hydrops fetalis, Pallor, Vaginal birth after Caesarian, Intrauterine growth reta... ORPHA:60041
Silver-Russell Syndrome Due To A Point Mutation
Postnatal growth retardation, Intrauterine growth retardation, Small placenta, Oligohydramnios ORPHA:397590
Fetal Akinesia Deformation Sequence 1
Hip contracture, Decreased fetal movement, Telecanthus, Premature birth, Elbow contracture, Campt... OMIM:208150
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Joint laxity, Epicanthus, Redundant neck skin, Polyhydramnios, Postnatal growth retardation, Larg... ORPHA:254528
Breath-Holding Spells
Pallor OMIM:607578
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Hemoglobin D Disease
Pallor ORPHA:90039
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Cyclic Vomiting Syndrome
Growth delay, Pallor OMIM:500007
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Rickets, Pallor, Short stature OMIM:611590
Anemia, Congenital Dyserythropoietic, Type Ib
Growth delay, Short stature, Pallor OMIM:615631
Hb Bart'S Hydrops Fetalis
Pallor, Hydrops fetalis, Polyhydramnios, Oligohydramnios ORPHA:163596
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Joint laxity, Growth delay, Pallor, Delayed puberty, Distichiasis OMIM:600462
Thiamine-Responsive Megaloblastic Anemia Syndrome
Short stature, Pallor ORPHA:49827
Beta-Thalassemia
Pallor, Skin ulcer, Reduced bone mineral density ORPHA:848
Myelofibrosis
Myelofibrosis, Pallor, Purpura OMIM:254450
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor, Nonimmune hydrops fetalis OMIM:266200
Fanconi Anemia, Complementation Group I
Fused cervical vertebrae, Short stature, Pallor, Intrauterine growth retardation OMIM:609053
Retinitis Pigmentosa 51
Pallor OMIM:613464
Hyperinsulinism Due To Ucp2 Deficiency
Pallor ORPHA:276556
Dravet Syndrome
Limited knee extension, Pallor ORPHA:33069
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Pallor ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor ORPHA:276580
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Restrictive Dermopathy 1
Spontaneous chorioamniotic separation, Polyhydramnios, Flexion contracture, Premature rupture of ... OMIM:275210
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Evans Syndrome
Pallor, Petechiae ORPHA:1959
Beta-Thalassemia Intermedia
Osteopenia, Osteoporosis, Skin ulcer, Increased susceptibility to fractures, Reduced bone mineral... ORPHA:231222
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor, Ptosis ORPHA:13
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Fanconi Anemia, Complementation Group C
Epicanthus, Anemic pallor, Short stature, Flexion contracture, Prolonged G2 phase of cell cycle, ... OMIM:227645
Anemia, Hypochromic Microcytic, With Iron Overload 2
Growth delay, Pallor OMIM:615234
Neu-Laxova Syndrome 1
Decreased fetal movement, Ablepharon, Spina bifida, Fetal akinesia sequence, Polyhydramnios, Abse... OMIM:256520
Greenberg Dysplasia
Polyhydramnios, Multiple prenatal fractures, Patchy variation in bone mineral density, Hydrops fe... OMIM:215140
Primary Myelofibrosis
Ecchymosis, Pallor, Petechiae, Purpura ORPHA:824
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Dominant Beta-Thalassemia
Osteoporosis, Skin ulcer, Upslanted palpebral fissure, Growth delay, Pallor, Delayed puberty ORPHA:231226
Irida Syndrome
Pallor ORPHA:209981
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Rheumatic Fever
Arthritis, Erythema, Pallor ORPHA:3099
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Hypophosphatemic rickets, Pallor ORPHA:263455
Prolactinoma
Osteopenia, Osteoporosis, Pallor, Delayed puberty, Ptosis ORPHA:2965
Deafness-Lymphedema-Leukemia Syndrome
Pallor ORPHA:3226
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Beta-Thalassemia Major
Osteoporosis, Skin ulcer, Upslanted palpebral fissure, Growth delay, Pallor, Delayed puberty ORPHA:231214
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Cold Agglutinin Disease
Pallor ORPHA:56425
Hereditary Spherocytosis
Growth delay, Skin ulcer, Pallor, Gout ORPHA:822
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Retinitis Pigmentosa 75
Pallor OMIM:617023
Myopathy, Mitochondrial, And Ataxia
Growth delay, Short stature, Pallor OMIM:617675
Kagami-Ogata Syndrome
Premature birth, Polyhydramnios, Postnatal growth retardation, Large placenta, Limitation of join... ORPHA:254519
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Idiopathic Pulmonary Hemosiderosis
Pallor ORPHA:99931
Congenital Dyserythropoietic Anemia Type Iii
Short stature, Pallor ORPHA:98870
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Conjunctival icterus, Pallor OMIM:194380
Sepsis In Premature Infants
Premature birth, Pallor, Caesarian section, Petechiae, Purpura ORPHA:90051
American Trypanosomiasis
Pallor ORPHA:3386
Tay-Sachs Disease
Pallor OMIM:272800
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Fumarase Deficiency
Conjunctival icterus, Bilateral fetal pyelectasis, Pallor, Polyhydramnios OMIM:606812
Diamond-Blackfan Anemia 1
Epicanthus, Premature birth, Short stature, Pallor, Intrauterine growth retardation, Spina bifida... OMIM:105650
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle, Anemic pallor, Short stature OMIM:600901
Trichohepatoenteric Syndrome 1
Short stature, Polyhydramnios, Large placenta, Abnormalities of placenta or umbilical cord, Intra... OMIM:222470
Degcags Syndrome
Osteopenia, Abnormal eyebrow morphology, Premature birth, Craniosynostosis, Echogenic fetal bowel... OMIM:619488
Elliptocytosis 1
Pallor OMIM:611804
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Growth delay, Pallor ORPHA:300298
Non-Functioning Pituitary Adenoma
Pallor, Ptosis ORPHA:91349
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle, Anemic pallor, Short stature OMIM:227650
Senior-Loken Syndrome 8
Pallor OMIM:616307
Systemic Mastocytosis With Associated Hematologic Neoplasm
Osteoporosis, Pallor, Increased susceptibility to fractures ORPHA:98849
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Pituitary Apoplexy
Pallor, Ptosis ORPHA:95613
Childhood Absence Epilepsy
Pallor ORPHA:64280
Letterer-Siwe Disease
Pallor OMIM:246400
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Epicanthus, Redundant neck skin, Premature birth, Interphalangeal joint contracture of finger, Po... ORPHA:96334
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Fanconi Anemia, Complementation Group D2
Blepharophimosis, Prolonged G2 phase of cell cycle, Anemic pallor, Short stature OMIM:227646
Autosomal Recessive Malignant Osteopetrosis
Recurrent fractures, Craniosynostosis, Reduced bone mineral density, Growth delay, Osteopetrosis,... ORPHA:667
Beta-Ketothiolase Deficiency
Pallor ORPHA:134
Hereditary Pheochromocytoma-Paraganglioma
Retinal capillary hemangioma, Pallor ORPHA:29072
Waldenström Macroglobulinemia
Pallor, Purpura ORPHA:33226
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Tsh-Secreting Pituitary Adenoma
Osteopenia, Osteoporosis, Pallor, Delayed puberty, Ptosis ORPHA:91347
Mosaic Trisomy 16
Large placenta, Single umbilical artery, Premature birth, Intrauterine growth retardation ORPHA:1708
Esophageal Atresia
Polyhydramnios, Growth delay, Pallor, Absence of stomach bubble on fetal sonography, Laryngotrach... ORPHA:1199
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Adenohypophysitis
Pallor ORPHA:95512
Meckel Syndrome, Type 1
Occipital encephalocele, Ptosis, Camptodactyly of finger, Breech presentation, Large placenta, An... OMIM:249000
Diamond-Blackfan Anemia
Epicanthus, Short stature, Nonimmune hydrops fetalis, Growth delay, Pallor, Ptosis ORPHA:124
3-Hydroxy-3-Methylglutaric Aciduria
Pallor ORPHA:20
Aregenerative Anemia
Pallor ORPHA:101096
Alternating Hemiplegia Of Childhood
Pallor, Thin eyebrow ORPHA:2131
Panhypophysitis
Pallor ORPHA:95513
Incontinentia Pigmenti
Erythema, Short stature, Pallor OMIM:308300
Sheehan Syndrome
Dry skin, Pallor ORPHA:91355
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Growth delay, Anemic pallor ORPHA:329971
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Pearson Marrow-Pancreas Syndrome
Pallor, Erythema, Hydrops fetalis OMIM:557000
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Idiopathic Hypereosinophilic Syndrome
Myelofibrosis, Arthritis, Pallor ORPHA:3260
Histiocytoid Cardiomyopathy
Pallor ORPHA:137675
Multiple Endocrine Neoplasia Type 2
Joint laxity, Pallor ORPHA:653
Infection-Related Hemolytic Uremic Syndrome
Septic arthritis, Pallor ORPHA:544482
Von Hippel-Lindau Disease
Retinal capillary hemangioma, Pallor ORPHA:892
Beckwith-Wiedemann Syndrome
Premature birth, Redundant skin, Polyhydramnios, Large placenta, Subchorionic septal cyst, Umbili... ORPHA:116
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Congenital Total Pulmonary Venous Return Anomaly
Low 1-minute APGAR score, Low 5-minute APGAR score, Pallor ORPHA:99125

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plk2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plk2.

No publications found that use IMPC mice or data for Plk2.

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MGI Allele Allele Type Produced
Plk2tm80676(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Plk2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Plk2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice

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