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Gene: Ogg1 MGI:1097693

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
8-oxoguanine DNA-glycosylase 1
Synonyms:
Mmh

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ogg1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ogg1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Renal Cell Carcinoma, Nonpapillary
Renal cell carcinoma OMIM:144700

The table below shows human diseases predicted to be associated to Ogg1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lung Cancer
Alveolar cell carcinoma, Lung adenocarcinoma, Non-small cell lung carcinoma OMIM:211980
Tumor Predisposition Syndrome 1
Uveal melanoma, Renal cell carcinoma, Cutaneous melanoma, Malignant mesothelioma, Lung adenocarci... OMIM:614327
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Colorectal Cancer, Susceptibility To, 12
Carcinoma OMIM:615083
Li-Fraumeni Syndrome
Neoplasm of the pancreas, Adrenocortical carcinoma, Soft tissue sarcoma, Breast carcinoma, Acute ... OMIM:151623
Neurodegeneration Due To Cerebral Folate Transport Deficiency
Neurodegeneration OMIM:613068
Diaminopentanuria
Neurodegeneration, Ataxia OMIM:222350
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Ceroid Lipofuscinosis, Neuronal, 7
Cerebellar atrophy, Ataxia, Cerebral atrophy, Neurodegeneration OMIM:610951
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano... OMIM:606719
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Xeroderma Pigmentosum, Complementation Group G
Defective DNA repair after ultraviolet radiation damage OMIM:278780
Neurodegeneration With Brain Iron Accumulation 6
Bradykinesia, Tip-toe gait, Gait disturbance, Neurodegeneration OMIM:615643
Nut Midline Carcinoma
Oropharyngeal squamous cell carcinoma, Pancreatoblastoma, Squamous cell carcinoma, Neoplasm, Panc... ORPHA:443167
Spastic Paraplegia 35, Autosomal Recessive, With Or Without Neurodegeneration
Cerebellar atrophy, Ataxia, Dysmetria, Dysdiadochokinesis, Neurodegeneration, Difficulty walking,... OMIM:612319
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Cerebellar atrophy, Neurodegeneration, Gait ataxia ORPHA:438134
Neurodegeneration With Brain Iron Accumulation 2A
Cerebellar atrophy, Ataxia, Unsteady gait, Cerebral atrophy, Gliosis, Neurodegeneration, Neuronal... OMIM:256600
Neurodegeneration, Childhood-Onset, With Brain Atrophy
Cerebellar atrophy, Ataxia, Inability to walk, Cerebral atrophy, Neurodegeneration, Cerebral cort... OMIM:617672
Leukoencephalopathy, Progressive, With Ovarian Failure
Cerebellar atrophy, Ataxia, Neurodegeneration OMIM:615889
Neurodegeneration With Brain Iron Accumulation 5
Cerebellar atrophy, Akinesia, Cerebral atrophy, Bradykinesia, Neurodegeneration OMIM:300894
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cerebellar atrophy, Ataxia, Gait apraxia, Limb ataxia, Dysmetria, Gait ataxia, Bradykinesia, Dysd... OMIM:615157
Bazex Syndrome
Neoplasm, Lung adenocarcinoma, Liposarcoma ORPHA:166113
Xeroderma Pigmentosum, Complementation Group F
Deficient excision of UV-induced pyrimidine dimers in DNA, Defective DNA repair after ultraviolet... OMIM:278760
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Abnormality of chromosome stability OMIM:600546
Opsoclonus-Myoclonus Syndrome
Ovarian teratoma, Small cell lung carcinoma, Breast carcinoma, Neoplasm of the lung, Melanoma, Ne... ORPHA:1183
Fanconi Renotubular Syndrome 5
Lung adenocarcinoma OMIM:618913
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
Neurodevelopmental Disorder With Dysmorphic Facies And Ischiopubic Hypoplasia
Splenomegaly, Leukopenia, Lymphopenia, Neurodegeneration OMIM:620210
Spastic Paraplegia 79B, Autosomal Recessive
Cerebellar atrophy, Ataxia, Cerebral atrophy, Dysmetria, Neurodegeneration, Loss of ambulation OMIM:615491
Neurodegeneration With Brain Iron Accumulation 3
Choreoathetosis, Ataxia, Bradykinesia, Neurodegeneration OMIM:606159
Xeroderma Pigmentosum, Complementation Group E
Defective DNA repair after ultraviolet radiation damage OMIM:278740
Hsd10 Disease, Infantile Type
Diffuse cerebral atrophy, Cerebral atrophy, Choreoathetosis, Frontotemporal cerebral atrophy, Neu... ORPHA:391428
Chediak-Higashi Syndrome
Impaired neutrophil bactericidal activity, Ataxia, Thrombocytopenia, Splenomegaly, Neutropenia, L... OMIM:214500
Legius Syndrome
Acute monocytic leukemia, Non-small cell lung carcinoma, Neurofibroma, Desmoid tumors, Ovarian ne... ORPHA:137605
Cerebrooculofacioskeletal Syndrome 1
Cerebellar atrophy, Diffuse cerebral atrophy, Gliosis, Neurodegeneration, Brain atrophy OMIM:214150
Krabbe Disease
Diffuse cerebral atrophy, Neurodegeneration, Autoimmune thrombocytopenia OMIM:245200
Cancer-Associated Retinopathy
Neoplasm of the pancreas, Pancreatic adenocarcinoma, Testicular neoplasm, Hematological neoplasm,... ORPHA:71505
Neurodegeneration With Brain Iron Accumulation 2B
Cerebellar atrophy, Dysmetria, Gait ataxia, Bradykinesia, Cerebral atrophy, Dysdiadochokinesis, N... OMIM:610217
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Pancytopenia, Ataxia, Cerebral atrophy, Gait ataxia, Gliosis, Neurodegeneration, Lethargy OMIM:618321
Pyruvate Dehydrogenase E2 Deficiency
Neurodegeneration, Broad-based gait, Gait disturbance, Difficulty walking ORPHA:79244
Xeroderma Pigmentosum, Complementation Group C
Defective DNA repair after ultraviolet radiation damage OMIM:278720
Asbestos Intoxication
Malignant mesothelioma, Lung adenocarcinoma ORPHA:2302
Lambert-Eaton Myasthenic Syndrome
Small cell lung carcinoma ORPHA:43393
Combined Oxidative Phosphorylation Deficiency 24
Cerebellar atrophy, Neuronal loss in central nervous system, Gliosis, Neurodegeneration OMIM:616239
Ataxia-Telangiectasia-Like Disorder 2
Cerebellar atrophy, Unsteady gait, Ataxia, Neurodegeneration OMIM:615919
Adrenoleukodystrophy
Neurodegeneration, Limb ataxia, Truncal ataxia OMIM:300100
Xeroderma Pigmentosum, Complementation Group A
Defective DNA repair after ultraviolet radiation damage OMIM:278700
Fanconi Anemia, Complementation Group E
Deficient excision of UV-induced pyrimidine dimers in DNA, Chromosomal breakage induced by crossl... OMIM:600901
Xeroderma Pigmentosum, Complementation Group D
Defective DNA repair after ultraviolet radiation damage OMIM:278730
Fanconi Anemia, Complementation Group A
Deficient excision of UV-induced pyrimidine dimers in DNA, Chromosomal breakage induced by crossl... OMIM:227650
Adrenocortical Carcinoma
Adrenocortical carcinoma, Lung adenocarcinoma ORPHA:1501
Amyotrophic Lateral Sclerosis
Motor neuron atrophy, Amyotrophic lateral sclerosis, Neurodegeneration ORPHA:803
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Neurodegeneration, Ataxia, Difficulty walking, Periventricular heterotopia OMIM:618476
Xfe Progeroid Syndrome
Defective DNA repair after ultraviolet radiation damage OMIM:610965
Combined Oxidative Phosphorylation Defect Type 29
Diffuse cerebellar atrophy, Axonal degeneration, Neurodegeneration, Global brain atrophy ORPHA:478029
Neurodegeneration With Brain Iron Accumulation 4
Cerebellar atrophy, Ataxia, Gait disturbance, Neurodegeneration, Loss of ambulation OMIM:614298
Fanconi Anemia, Complementation Group C
Deficient excision of UV-induced pyrimidine dimers in DNA, Chromosomal breakage induced by crossl... OMIM:227645
Multiple System Atrophy 1, Susceptibility To
Bradykinesia, Ataxia, Neurodegeneration OMIM:146500
Trichothiodystrophy
Defective DNA repair after ultraviolet radiation damage ORPHA:33364
Neurodegeneration With Brain Iron Accumulation 1
Ataxia, Akinesia, Acanthocytosis, Choreoathetosis, Bradykinesia, Gait disturbance, Neurodegenerat... OMIM:234200
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Ataxia, Cerebral atrophy, Gait ataxia, Neurodegeneration, Gait disturbance OMIM:616878
Gm2 Gangliosidosis, Ab Variant
Neurodegeneration, Cerebral atrophy ORPHA:309246
Fanconi Anemia, Complementation Group D2
Deficient excision of UV-induced pyrimidine dimers in DNA, Chromosomal breakage induced by crossl... OMIM:227646
De Sanctis-Cacchione Syndrome
Defective DNA repair after ultraviolet radiation damage OMIM:278800
Cerebral Visual Impairment
Central nervous system degeneration, Neurodegeneration ORPHA:447788
Gm2-Gangliosidosis, Ab Variant
Neurodegeneration, Cerebral atrophy OMIM:272750
Dermatomyositis
Gastrointestinal stroma tumor, Lymphoma, Breast carcinoma, Neoplasm, Lung adenocarcinoma ORPHA:221
Cushing Syndrome Due To Ectopic Acth Secretion
Pancreatic adenocarcinoma, Pancreatoblastoma, Pituitary corticotropic cell adenoma, Neoplasm of t... ORPHA:99889
Mucopolysaccharidosis, Type Ii
Splenomegaly, Neurodegeneration, Hepatosplenomegaly OMIM:309900
Hurler Syndrome
Splenomegaly, Neurodegeneration, Hepatosplenomegaly OMIM:607014
Renal Cell Carcinoma, Nonpapillary
Renal cell carcinoma OMIM:144700
Nijmegen Breakage Syndrome
Autoimmune hemolytic anemia, Glioma, T lymphocytopenia, B lymphocytopenia, Neurodegeneration, Thr... OMIM:251260
Mucopolysaccharidosis, Type Vii
Splenomegaly, Neurodegeneration OMIM:253220
Sotos Syndrome
Sacrococcygeal teratoma, Astrocytoma, Small cell lung carcinoma, Acute lymphoblastic leukemia, Ne... ORPHA:821
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Broad-based gait, Ataxia, Tip-toe gait, Neurodegeneration, Falls OMIM:619475
Primrose Syndrome
Neurodegeneration, Ataxia OMIM:259050

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ogg1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ogg1.

No publications found that use IMPC mice or data for Ogg1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ogg1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ogg1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ogg1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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