Gene: Sema3f

Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Synonyms
  • Sema IV
  • Semak

Status ES CellsMice
tm1c
Mice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1096347   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Sema3f

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sema3f data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Sema3ftm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
limb grasping Sema3ftm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.47E-9
abnormal gait Sema3ftm1b(EUCOMM)Hmgu HOM Female postnatal 5.34E-7
decreased circulating serum albumin level Sema3ftm1b(EUCOMM)Hmgu HOM Female Male postnatal 7.51E-7
increased circulating iron level Sema3ftm1b(EUCOMM)Hmgu HOM Female postnatal 3.4E-6
abnormal bone structure Sema3ftm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.89E-6
decreased circulating total protein level Sema3ftm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.73E-6
cataract Sema3ftm1b(EUCOMM)Hmgu HOM Male postnatal 1.4E-5
abnormal nail morphology Sema3ftm1b(EUCOMM)Hmgu HOM Male postnatal 2.3E-5
hypoactivity Sema3ftm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.12E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354)
Aorta 2 No (2/530) (2/2)
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354) (2/2)
Eye 2 No (1/530) (2/2)
Gall bladder 2 No
Heart 2 No (4/530)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354) (2/2)
Oral epithelium 2 No (2/2)
Ovary 2 No (1/530)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530)
Parathyroid gland 2 No (2/516)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No
Skin 2 No (2/530) (2/2)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530) (2/2)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530) (2/2)
Thyroid gland 2 No (11/530) (2/2)
Trachea 2 No (5/530) (2/2)
Uterus 2 No (1/530)
Vascular system 2 No (1/354) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    nervous system
    sensory organ
    reproductive system
    immune system
    integumental system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413) (4/4)
Ear 2 (2/4)
Embryo 2 (4/4)
Eye 2 (4/4)
Foot 2 (4/4)
Forebrain 2 (4/4)
Forelimb 2 (4/4)
Hand 2 (4/4)
Head 2 (4/413) (4/4)
Heart 2 (2/4)
Hindbrain 2 (5/413) (3/4)
Hindlimb 2 (4/4)
Liver 2 (1/4)
Lung 2 (1/4)
Mandibular process 2 (2/4)
Maxillary process 2 (2/4)
Midbrain 2 (4/4)
Oral cavity 2 (2/4)
Skin 2 (2/4)
Tail 2 (4/4)
Tail somite 2 (2/4)


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    8 Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    20 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Sema3ftm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp)
Vector
Gene
Sema3ftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Sema3ftm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene