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Gene: Hrh2 MGI:108482

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
histamine receptor H2
Synonyms:
H2r

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hrh2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hrh2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Polyposis of gastric fundus without polyposis coli
Abnormal gastric mucosa morphology, Multiple gastric polyps OMIM:175505
Gastric Cancer
Stomach cancer OMIM:613659
Ménétrier Disease
Gastrointestinal hemorrhage, Helicobacter pylori infection, Nausea, Anorexia, Abnormal gastric mu... ORPHA:2494
Nk-Cell Enteropathy
Colonic diverticula, Duodenal ulcer, Abnormal gastric mucosa morphology, Diarrhea, Hematochezia, ... ORPHA:263665
Oculogastrointestinal Muscular Dystrophy
Abnormality of the gastrointestinal tract, Spontaneous esophageal perforation, Intestinal pseudo-... ORPHA:1876
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
Absence of intrinsic factor OMIM:243320
Pyloric Atresia
Congenital pyloric atresia OMIM:265950
Inflammatory Bowel Disease (Crohn Disease) 30
Gastritis, Duodenitis, Chronic diarrhea, Pancolitis, Bloody diarrhea, Vomiting, Abnormal intestin... OMIM:619079
Diffuse Gastric And Lobular Breast Cancer Syndrome
Stomach cancer, Atrophic gastritis, Cleft palate OMIM:137215
Dubin-Johnson Syndrome
Abnormal gastric mucosa morphology ORPHA:234
Syndromic Recessive X-Linked Ichthyosis
Abnormal stomach morphology, Cryptorchidism, Seizure, Hypogonadism, Attention deficit hyperactivi... ORPHA:281090
Necrotizing Encephalomyelopathy, Subacute, Of Leigh, Adult
Gastric ulcer, Gastric hypertrophy OMIM:161700
Pyloric Stenosis, Infantile Hypertrophic, 1
Pyloric stenosis, Projectile vomiting OMIM:179010
Tumor Predisposition Syndrome 4
Stomach cancer OMIM:609265
Colorectal Cancer
Hereditary nonpolyposis colorectal carcinoma, Neoplasm of the stomach OMIM:114500
Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach
Melena, Fundic gland polyposis, Gastric adenocarcinoma OMIM:619182
Chronic Intestinal Pseudoobstruction
Pyloric stenosis, Abnormal intestine morphology, Intestinal malrotation ORPHA:2978
Serrated Polyposis Syndrome
Pancreatic adenocarcinoma, Biliary tract neoplasm, Gastric diverticulum, Adenomatous colonic poly... ORPHA:157798
Reynolds Syndrome
Abnormal gastric mucosa morphology, Gastroesophageal reflux, Xerostomia, Dysphagia ORPHA:779
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Congenital pyloric atresia OMIM:612138
Cap Polyposis
Atrophic gastritis, Diarrhea, Hematochezia, Constipation, Colorectal polyposis ORPHA:160148
Alpha-1-Antitrypsin Deficiency
Gastric varix, Hepatocellular carcinoma OMIM:613490
Fg Syndrome 3
Chronic constipation, Hyperactivity, Pyloric stenosis, Cryptorchidism OMIM:300406
Gastritis, Familial Giant Hypertrophic
Giant hypertrophic gastritis OMIM:137280
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal pseudo-obstruction, Intestinal malrotation, Pyloric stenosis, Seizure, Vomiting, Conge... OMIM:300048
Intrinsic Factor Deficiency
Absence of intrinsic factor OMIM:261000
Immunodeficiency 57 With Autoinflammation
Perianal abscess, Diarrhea, Gastritis, Inflammation of the large intestine OMIM:618108
Wolfram Syndrome
Gastrointestinal hemorrhage, Diabetes mellitus, Ataxia, Malabsorption, Seizure, Gastric ulcer, Co... ORPHA:3463
Periventricular Nodular Heterotopia
Focal-onset seizure, Pyloric stenosis, Gastroesophageal reflux ORPHA:98892
Visceral Myopathy 2
Intestinal obstruction, Necrotizing enterocolitis, Gastroparesis, Intestinal malrotation, Intesti... OMIM:619350
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Esophageal stenosis, Congenital pyloric atresia OMIM:619817
Esophageal Ring, Lower
Hiatus hernia, Dysphagia OMIM:133240
Thrombocytopenia, Paris-Trousseau Type
Pyloric stenosis OMIM:188025
Bronchogenic Cyst
Abnormal stomach morphology, Abnormal esophagus morphology, Dysphagia ORPHA:2357
Metachromatic Leukodystrophy
Ataxia, Bowel incontinence, Abnormal stomach morphology, Neoplasm of the gallbladder, Abnormal ga... ORPHA:512
Gastrointestinal Stromal Tumor
Gastrointestinal hemorrhage, Intestinal obstruction, Neoplasm of the colon, Neoplasm of the stoma... ORPHA:44890
Houge-Janssens Syndrome 1
Multifocal seizures, Pyloric stenosis, Chronic diarrhea, Gait ataxia, Seizure OMIM:616355
Familial Melanoma
Neoplasm of the pancreas, Neoplasm of the stomach ORPHA:618
Chromosome 19Q13.11 Deletion Syndrome, Proximal
Pyloric stenosis, Seizure OMIM:617219
Ornithine Transcarbamylase Deficiency
Pyloric stenosis ORPHA:664
Msh3-Related Attenuated Familial Adenomatous Polyposis
Ovarian dermoid cyst, Juvenile gastrointestinal polyposis, Adenomatous colonic polyposis, Multipl... ORPHA:480536
Wolfram Syndrome 2
Diabetes mellitus, Gastric ulcer OMIM:604928
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Esophageal ulceration, Gastric ulcer, Duodenal ulcer OMIM:618372
External Auditory Canal, Bilateral Atresia Of, With Congenital Vertical Talus
Pyloric stenosis OMIM:133705
Juvenile Polyposis Syndrome
Neoplasm of the stomach, Diarrhea, Rectal prolapse, Multiple gastric polyps, Hematochezia, Colon ... OMIM:174900
Arteriosclerosis, Severe Juvenile
Gastric ulcer, Delayed puberty OMIM:208060
Immunodeficiency, Common Variable, 12, With Autoimmunity
Atrophic gastritis OMIM:616576
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Small intestinal polyposis, Duodenal polyposis, Rectal polyposis, Adenomatous colonic polyposis, ... ORPHA:329971
Cystic Fibrosis-Gastritis-Megaloblastic Anemia Syndrome
Diarrhea, Gastritis ORPHA:2575
Attenuated Familial Adenomatous Polyposis
Duodenal polyposis, Neoplasm of the stomach, Rectal polyposis, Adenomatous colonic polyposis, Lar... ORPHA:220460
Microcephalic Primordial Dwarfism, Montreal Type
Cryptorchidism, Congenital pyloric atresia ORPHA:2617
Muir-Torre Syndrome
Neoplasm of the stomach, Salivary gland neoplasm, Neoplasm of the liver, Adenoma sebaceum, Colon ... ORPHA:587
Familial Adenomatous Polyposis 4
Duodenal polyposis, Gastric adenocarcinoma, Adenomatous colonic polyposis, Ovarian cyst, Thyroid ... OMIM:617100
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Atrophic gastritis, Bilateral tonic-clonic seizure, Diarrhea, Lymphocytic infiltration of the col... ORPHA:436159
Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia
Intractable diarrhea, Esophageal atresia, Congenital pyloric atresia OMIM:226730
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
Hypoparathyroidism, Atrophic gastritis, Female hypogonadism, Decreased circulating parathyroid ho... OMIM:240300
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Esophageal varix, Gastric varix, Hepatocellular carcinoma ORPHA:64743
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Diarrhea, Atrophic gastritis, Lymphocytic infiltration of the colorectal mucosa, Crohn's disease OMIM:616100
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Abnormal small intestine morphology, Barrett esophagus... ORPHA:90291
Williams Syndrome
Rectal prolapse, Dysmetria, Gastroesophageal reflux, Compulsive behaviors, Hypothyroidism, Ataxia... ORPHA:904
Microgastria-Limb Reduction Defect Syndrome
Intestinal malrotation, Hiatus hernia, Esophageal atresia, Rectal atresia, Tracheoesophageal fist... ORPHA:2538
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Chronic gastritis, Perianal abscess, Diarrhea, Chronic constipation, Inflammation of the large in... OMIM:301074
Congenital Tracheal Stenosis
Abnormal stomach morphology, Tracheoesophageal fistula, Duodenal stenosis, Meckel diverticulum, A... ORPHA:141127
Ethylene Glycol Poisoning
Gastritis, Ataxia, Seizure, Addictive alcohol use, Vomiting, Myoclonus, Nausea ORPHA:31826
Mixed Connective Tissue Disease
Gastrointestinal hemorrhage, Gastritis, Xerostomia, Seizure, Gastroesophageal reflux ORPHA:809
Knobloch Syndrome 2
Chronic constipation, Seizure, Pyloric stenosis OMIM:618458
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Hyperthyroidism, Gastritis, Malabsorption, Abnormality of the endocrine system, Ileus, Secretory ... ORPHA:37042
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Broad-based gait, Bilateral tonic-clonic seizure with generalized onset, Esophageal varix, Limb a... ORPHA:2072
Autoimmune Polyendocrinopathy Type 4
Atrophic gastritis, Hypergonadotropic hypogonadism, Celiac disease, Xerostomia, Primary adrenal i... ORPHA:227990
Autoimmune Polyendocrinopathy Type 3
Atrophic gastritis, Hypergonadotropic hypogonadism, Autoimmune hypoparathyroidism, Celiac disease... ORPHA:227982
Immunodeficiency, Common Variable, 8, With Autoimmunity
Atrophic gastritis, Villous atrophy, Chronic diarrhea, Thyroiditis, Inflammation of the large int... OMIM:614700
Epidermolysis Bullosa Simplex With Pyloric Atresia
Vomiting, Congenital pyloric atresia ORPHA:158684
Zygomycosis
Gastrointestinal hemorrhage, Diabetes mellitus, Gastritis, Hematemesis, Diarrhea, Peritonitis, En... ORPHA:73263
Junctional Epidermolysis Bullosa With Pyloric Atresia
Congenital pyloric atresia, Intestinal atresia ORPHA:79403
Hardikar Syndrome
Decreased serum insulin-like growth factor 1, Cleft soft palate, Intestinal malrotation, Hemateme... OMIM:301068
Syndromic Diarrhea
Villous atrophy, Gastritis, Hepatoblastoma, Bloody diarrhea, Colitis, Hypoplasia of the thymus, I... ORPHA:84064
Coffin-Siris Syndrome 1
Duodenal ulcer, Intestinal malrotation, Aggressive behavior, Cryptorchidism, Cleft palate, Gait a... OMIM:135900
Immunodeficiency 82 With Systemic Inflammation
Villous atrophy, Gastritis, Duodenal ulcer, Anorexia, Diarrhea, Colitis, Vomiting, Anoperineal fi... OMIM:619381
Autoimmune Lymphoproliferative Syndrome
Gastritis, Thyroiditis, Colitis, Thyroid carcinoma, Recurrent aphthous stomatitis, Thyroid adenom... ORPHA:3261
Viss Syndrome
Chronic gastritis, Duodenitis, Intestinal malrotation, Cleft soft palate, Submucous cleft soft pa... OMIM:619472

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hrh2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hrh2.

No publications found that use IMPC mice or data for Hrh2.

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MGI Allele Allele Type Produced
Hrh2tm90546(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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