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Gene: Rad21 MGI:108016

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
RAD21 cohesin complex component
Synonyms:
SCC1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rad21 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rad21 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cornelia De Lange Syndrome
Hypoplasia of penis, Hypospadias, Cryptorchidism, Primary amenorrhea, Hypoplastic labia majora, A... ORPHA:199
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
OMIM:614701
Mungan Syndrome
OMIM:611376
Trichorhinophalangeal Syndrome Type 2
ORPHA:502

The table below shows human diseases predicted to be associated to Rad21 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cornelia De Lange Syndrome
Hypoplasia of penis, Hypospadias, Cryptorchidism, Primary amenorrhea, Hypoplastic labia majora, A... ORPHA:199
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
OMIM:614701
Mungan Syndrome
OMIM:611376
Trichorhinophalangeal Syndrome Type 2
ORPHA:502

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rad21

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rad21.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes. Current biology : CB (March 2019) Rad21ltm1b(KOMP)Wtsi 30853435
Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology (January 2017) Rad21ltm1b(KOMP)Wtsi PMC5441961
Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L. G3 (Bethesda, Md.) (June 2016) Rad21ltm1b(KOMP)Wtsi PMC4889667

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MGI Allele Allele Type Produced
Rad21tm277927(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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