Gene: Prmt1

Name protein arginine N-methyltransferase 1

Synonyms
  • Hrmt1l2
  • 6720434D09Rik

Status ES CellsMice
tm1a
Mice
tm1c
phenotype data available

Links MGI:107846   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Prmt1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Prmt1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Prmt1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased circulating creatinine level Prmt1tm1a(EUCOMM)Wtsi HET Female Male postnatal 8.69E-6
increased startle reflex Prmt1tm1a(EUCOMM)Wtsi HET Female Male postnatal 9.74E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/176) (3/4)
Aorta 4 No (2/530)
Blood vessel 4 No
Bone 4 No (1/515) (2/4)
Brain 4 No (8/530) (4/4)
Brainstem 4 No (5/530)
Brown adipose tissue 4 No
Cartilage tissue 4 No (1/530) (3/4)
Cerebellum 4 No (6/530)
Cerebral cortex 4 No (6/530)
Eye 4 No (1/530) (2/4)
Gall bladder 4 No (2/4)
Heart 4 No (4/530) (3/4)
Hippocampus 4 No (7/530)
Hypothalamus 4 No (5/529)
Kidney 4 No (13/530) (3/4)
Large intestine 4 No (7/530) (3/4)
Liver 4 No
Lower urinary tract 4 No (3/530) (3/4)
Lung 4 No (4/530) (2/4)
Lymph node 4 No (2/530) (3/4)
Mammary gland 4 No (1/4)
Esophagus 4 No (3/4)
Olfactory lobe 4 No (2/176)
Ovary 4 No (1/530) (2/4)
Oviduct 4 No (1/530) (2/4)
Pancreas 4 No (2/530) (3/4)
Parathyroid gland 4 No (2/516) (1/4)
Peripheral nervous system 4 No (4/530) (4/4)
Peyer's patch 4 No (1/176) (3/4)
Pituitary gland 4 No (2/530) (3/4)
Prostate gland 4 No (3/530) (2/4)
Skeletal muscle tissue 4 No (4/4)
Skin 4 No (2/530) (3/4)
Small intestine 4 No (5/530) (3/4)
Spinal cord 4 No (5/530) (4/4)
Spleen 4 No (3/530) (3/4)
Stomach 4 No (5/530) (3/4)
Striatum 4 No (6/530)
Testis 4 No (7/530) (2/4)
Thymus 4 No (1/530) (3/4)
Thyroid gland 4 No (11/530) (1/4)
Trachea 4 No (5/530) (3/4)
Uterus 4 No (1/530) (2/4)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (15)
  • Prmt1tm1a(EUCOMM)Wtsi
    HEART, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    LUNG, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    OVARY, UTERUS, OVIDUCT, HET, Female, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Male, WTSI

show all 15 images

digestive system (4)
  • Prmt1tm1a(EUCOMM)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    ESOPHAGUS, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    LARGE INTESTINE, HET, Male, WTSI
immune system (4)
  • Prmt1tm1a(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    LYMPH NODE, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    THYMUS, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    SPLEEN, HET, Male, WTSI
integumental system (4)
  • Prmt1tm1a(EUCOMM)Wtsi
    SKIN, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    AURICLE, SKIN, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    SKIN, TAIL, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    MAMMARY GLAND, INGUINAL FAT PAD, HET, Female, WTSI
nervous system (4)
  • Prmt1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    PITUITARY GLAND, PERIPHERAL NERVOUS SYSTEM, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Male, WTSI
musculoskeletal system (3)
  • Prmt1tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, CARTILAGE TISSUE, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, HET, Female, WTSI
endocrine system (2)
  • Prmt1tm1a(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    THYROID GLAND, HET, Female, WTSI
reproductive system (2)
  • Prmt1tm1a(EUCOMM)Wtsi
    OVARY, UTERUS, OVIDUCT, HET, Female, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
sensory organ (2)
  • Prmt1tm1a(EUCOMM)Wtsi
    AURICLE, SKIN, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    EYE, HET, Male, WTSI
set of connective tissues (2)
  • Prmt1tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, CARTILAGE TISSUE, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    MAMMARY GLAND, INGUINAL FAT PAD, HET, Female, WTSI
urinary system (2)
  • Prmt1tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    LOWER URINARY TRACT, URINARY BLADDER, HET, Male, WTSI
adipose tissue (1)
  • Prmt1tm1a(EUCOMM)Wtsi
    MAMMARY GLAND, INGUINAL FAT PAD, HET, Female, WTSI
cardiovascular system (1)
  • Prmt1tm1a(EUCOMM)Wtsi
    HEART, HET, Male, WTSI
exocrine system (1)
  • Prmt1tm1a(EUCOMM)Wtsi
    MAMMARY GLAND, INGUINAL FAT PAD, HET, Female, WTSI
respiratory system (1)
  • Prmt1tm1a(EUCOMM)Wtsi
    LUNG, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (143)
  • Prmt1tm1a(EUCOMM)Wtsi
    TRUNK, WT, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    TRUNK, WT, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    TRUNK, WT, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    HEAD, WT, Male, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    LOWER ARM, WT, Male, WTSI

show all 143 images

Skin Histopathology (3)
  • Prmt1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Prmt1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Prmt1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Prmt1tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene