Gene: Dctn2

Name dynactin 2

Synonyms
  • C130077D06Rik
  • DCTN-50
  • 2310042E05Rik
  • RBP50
  • p50

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:107733   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Dctn2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dctn2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Dctn2tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
prolonged ST segment Dctn2tm1b(EUCOMM)Hmgu HET Female Male postnatal 2.99E-17
prolonged QT interval Dctn2tm1b(EUCOMM)Hmgu HET Female Male postnatal 1.72E-15
cardiovascular system phenotype Dctn2tm1b(EUCOMM)Hmgu HET Female Male postnatal 2.87E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/354)
Aorta 4 No (2/530)
Bone 4 No (1/515) (4/4)
Brain 4 No (8/530) (4/4)
Brainstem 4 No (5/530)
Brown adipose tissue 4 No
Cartilage tissue 4 No (1/530) (4/4)
Cecum 4 No (1/325) (4/4)
Cerebellum 4 No (6/530)
Cerebral cortex 4 No (6/530) (4/4)
Chest bone 4 No (4/4)
Colon 4 No (1/99) (4/4)
Cranium 4 No
Diaphragm 4 No
Duodenum 4 No (1/99) (4/4)
Epididymis 4 No (1/103)
Esophagus 4 No (1/354) (4/4)
Eye 4 No (1/530) (3/4)
Gall bladder 4 No
Gonadal fat pad 4 No (4/4)
Harderian gland 4 No (4/4)
Heart 4 No (4/530) (4/4)
Hindlimb 4 No (4/4)
Hippocampus 4 No (7/530) (4/4)
Hypothalamus 4 No (5/529) (4/4)
Ileum 4 No (1/99) (4/4)
Jejunum 4 No (1/99) (4/4)
Kidney 4 No (13/530) (4/4)
Large intestine 4 No (7/530) (4/4)
Liver 4 No
Lower urinary tract 4 No (3/530) (4/4)
Lung 4 No (4/530) (4/4)
Lymph node 4 No (2/530)
Main olfactory bulb 4 No (4/4)
Mammary gland 4 No (2/4)
Mesenteric lymph node 4 No
Mesenteric adipose tissue 4 No (4/4)
Midbrain 4 No
Olfactory lobe 4 No (3/354) (4/4)
Oral epithelium 4 No
Ovary 4 No (1/530) (2/4)
Oviduct 4 No (1/530) (2/4)
Pancreas 4 No (2/530) (4/4)
Parathyroid gland 4 No (2/516) (4/4)
Parotid gland 4 No (4/4)
Penis 4 No (2/4)
Peripheral nervous system 4 No (4/530)
Peyer's patch 4 No (1/354)
Pituitary gland 4 No (2/530) (4/4)
Prostate gland 4 No (3/530)
Quadriceps 4 No
Sciatic nerve 4 No (4/4)
Skeletal muscle 4 No
Skin 4 No (2/530) (4/4)
Small intestine 4 No (5/530) (4/4)
Spinal cord 4 No (5/530) (4/4)
Spleen 4 No (3/530)
Stomach 4 No (5/530) (4/4)
Stomach pyloric region 4 No
Striatum 4 No (6/530)
Sublingual gland 4 No (4/4)
Submandibular gland 4 No (4/4)
Testis 4 No (7/530) (2/4)
Thalamus 4 No (4/4)
Thymus 4 No (1/530)
Thyroid gland 4 No (11/530)
Tongue 4 No (4/4)
Trachea 4 No (5/530) (4/4)
Trigeminal V nerve 4 No (4/4)
Urinary bladder 4 No (4/4)
Uterus 4 No (1/530) (2/4)
Vagina 4 No (2/4)
Vas deferens 4 No (1/331)
Vascular system 4 No (1/354) (4/4)
Vesicular gland 4 No
White adipose tissue 4 No (4/4)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    limb
    endocrine system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 7 (5/413) (7/7)
Ear 7
Embryo 7 (7/7)
Eye 7 (7/7)
Foot 7
Forearm 7 (7/7)
Forebrain 7 (7/7)
Forelimb 7 (7/7)
Hand 7
Head 7 (4/413) (7/7)
Heart 7 (7/7)
Hindbrain 7 (5/413) (7/7)
Hindlimb 7 (7/7)
Liver 7
Lower leg 7 (7/7)
Lung 7
Mandibular process 7
Maxillary process 7
Midbrain 7
Oral cavity 7
Skin 7
Tail 7 (7/7)
Tail somite 7 (7/7)
Upper arm 7 (7/7)
Upper leg 7 (7/7)
  • alimentary system(2)
    Mandibular process ambiguous
    Maxillary process ambiguous
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • head(3)
    Eye expression
    EMAPA:16198 eye
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    202 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Embryo LacZ: LacZ images wholemount
    80 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Eye Morphology: Images Ophthalmoscopy
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Dctn2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dctn2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Dctn2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene