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Gene: Larp7 MGI:107634

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Gene Summary

Name:
La ribonucleoprotein 7, transcriptional regulator
Synonyms:
C330027G06Rik,  D3Wsu161e

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Larp7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Larp7 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Alazami Syndrome
Retractile testis OMIM:615071
Alazami Syndrome
ORPHA:319671

The table below shows human diseases predicted to be associated to Larp7 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect, Gonadal dysgenesis OMIM:615041
Spina Bifida-Hypospadias Syndrome
Hypospadias, Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Caudal Duplication
Abnormal penis morphology, Spina bifida, Cryptorchidism, Myelomeningocele, Uterus didelphys ORPHA:1756
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Subependymal Nodular Heterotopia
Occipital encephalocele, Myelomeningocele, Meningocele, Nasofrontal encephalocele ORPHA:101030
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Triploidy
Hypoplasia of penis, Hypospadias, Cryptorchidism, Hydrocephalus, Meningocele, Holoprosencephaly, ... ORPHA:3376
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holoprosencephaly, Int... ORPHA:1908
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Lumbar Syndrome
Bifid scrotum, Hypospadias, Spina bifida, Bifid uterus, Cryptorchidism, Myelomeningocele, Hypopla... ORPHA:83628
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Intrauterine growth retardation OMIM:611134
Schisis Association
Encephalocele, Anencephaly, Spina bifida ORPHA:63862
Meckel Syndrome, Type 2
Encephalocele, Intrauterine growth retardation, Meningocele, Anencephaly OMIM:603194
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida OMIM:207950
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Autosomal Recessive Spondylocostal Dysostosis
Hypospadias, Cryptorchidism, Meningocele, Abnormal morphology of female internal genitalia, Umbil... ORPHA:2311
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Pagod Syndrome
Encephalocele, Death in infancy, Spina bifida, Meningocele, Abnormal morphology of female interna... ORPHA:991
Camptodactyly Syndrome, Guadalajara Type 1
Intrauterine growth retardation, Spina bifida ORPHA:1327
Wildervanck Syndrome
Meningocele ORPHA:3456
Cerebrocostomandibular Syndrome
Death in infancy, Spina bifida, Myelomeningocele, Meningocele, Hydranencephaly, Intrauterine grow... ORPHA:1393
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Humero-Radial Synostosis
Meningocele ORPHA:3265
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Sirenomelia
Ambiguous genitalia, Spina bifida, Sirenomelia ORPHA:3169
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Neurocutaneous Melanocytosis
Death in infancy, Meningocele ORPHA:2481
Czeizel-Losonci Syndrome
Myelomeningocele, Spina bifida occulta, Hydrocephalus, Spina bifida ORPHA:2437
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Death in infancy, Spina bifida ORPHA:1120
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Amish Lethal Microcephaly
Death in infancy, Spina bifida ORPHA:99742
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Acromelic Frontonasal Dysplasia
Encephalocele, Cryptorchidism, Meningocele ORPHA:1827
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida, Ambiguous genitalia ORPHA:2839
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Vacterl With Hydrocephalus
Spina bifida, Aqueductal stenosis, Cryptorchidism, Hydrocephalus, Abnormal fallopian tube morphol... ORPHA:3412
Mosaic Trisomy 9
Hypoplasia of penis, Spina bifida, Cryptorchidism, Abnormality of the uterus, Abnormal fallopian ... ORPHA:99776
Joubert Syndrome 14
Encephalocele, Hydrocephalus, Meningocele OMIM:614424
Trisomy 20P
Hypospadias, Spina bifida, Cryptorchidism, Macroorchidism, Umbilical hernia ORPHA:261318
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Lateral Meningocele Syndrome
Umbilical hernia, Meningocele, Cryptorchidism ORPHA:2789
Iniencephaly
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Hol... ORPHA:63259
Lateral Meningocele Syndrome
Umbilical hernia, Hydrocephalus, Meningocele, Cryptorchidism OMIM:130720
Trisomy 18
Spina bifida, Cryptorchidism, Anencephaly, Holoprosencephaly, Intrauterine growth retardation, Ab... ORPHA:3380
Chromosome 17P13.1 Deletion Syndrome
Hydrocele testis, Umbilical hernia, Hydrocephalus, Spina bifida OMIM:613776
Neu-Laxova Syndrome
External genital hypoplasia, Spina bifida, Hypogonadism, Ambiguous genitalia, Intrauterine growth... ORPHA:2671
Phakomatosis Pigmentokeratotica
Precocious puberty, Cryptorchidism, Spina bifida ORPHA:2874
Cloacal Exstrophy
Hypoplasia of penis, Spina bifida, Myelomeningocele, Abnormality of the clitoris, Abnormal fallop... ORPHA:93929
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Phocomelia, Schinzel Type
Hypoplasia of penis, Cryptorchidism, Meningocele, Aplasia of the uterus, Intrauterine growth reta... ORPHA:2879
Neu-Laxova Syndrome 2
Intrauterine growth retardation, Spina bifida OMIM:616038
Neu-Laxova Syndrome 1
Spina bifida, Bifid uterus, Cryptorchidism, Stillbirth, Neonatal death, Small placenta, Short umb... OMIM:256520
Fanconi Anemia
Hypospadias, Spina bifida, Abnormal preputium morphology, Cryptorchidism, Hydrocephalus, Azoosper... ORPHA:84
Lathosterolosis
Intrauterine growth retardation, Hypoplasia of penis, Meningocele ORPHA:46059
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele, Hypospadias ORPHA:397715
Exstrophy-Epispadias Complex
Bifid scrotum, Spina bifida, Bifid uterus, Cryptorchidism, Hydrocephalus, Epispadias, Cystocele, ... ORPHA:322
Waardenburg Syndrome, Type 1
Myelomeningocele, Aplasia of the vagina, Spina bifida OMIM:193500
Hallermann-Streiff Syndrome
Cryptorchidism, Spina bifida OMIM:234100
Jacobsen Syndrome
Cryptorchidism, Intrauterine growth retardation, Spina bifida, Death in infancy ORPHA:2308
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Occipital meningocele, Hydrocephalus, Anencephaly, Micropenis OMIM:616546
22Q11.2 Deletion Syndrome
Hypospadias, Spina bifida, Cryptorchidism, Hydrocephalus, Meningocele, Occipital myelomeningocele... ORPHA:567
Limb Body Wall Complex
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Short umbilical cord, ... ORPHA:2369
Basal Cell Nevus Syndrome 1
Hydrocephalus, Ovarian fibroma, Ovarian carcinoma, Spina bifida OMIM:109400
Nail-Patella Syndrome
Spina bifida OMIM:161200
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Koolen-De Vries Syndrome Due To A Point Mutation
Hypospadias, Testicular neoplasm, Spina bifida, Precocious puberty, Cryptorchidism, Hydrocephalus ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hypospadias, Testicular neoplasm, Spina bifida, Precocious puberty, Cryptorchidism, Hydrocephalus ORPHA:363958
Fibular Hemimelia
Spina bifida ORPHA:93323
Thrombocytopenia-Absent Radius Syndrome
Death in infancy, Aplasia of the uterus, Spina bifida OMIM:274000
Rubinstein-Taybi Syndrome 1
Hypospadias, Spina bifida, Premature thelarche, Bilateral cryptorchidism, Cryptorchidism, Papilla... OMIM:180849
Split Cord Malformation
Hypospadias, Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydrocep... ORPHA:573278
Campomelic Dysplasia
Hypospadias, Spina bifida, Hydrocephalus, Spinal dysraphism, Sex reversal OMIM:114290
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Hypospadias, Spina bifida ORPHA:508498
Aicardi Syndrome
Precocious puberty, Spina bifida OMIM:304050
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Otopalatodigital Syndrome, Type Ii
Hypospadias, Spina bifida, Cryptorchidism, Hydrocephalus, Stillbirth, Umbilical hernia OMIM:304120
Orofaciodigital Syndrome Vi
Occipital meningocele OMIM:277170
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Vater/Vacterl Association
Occipital encephalocele, Hypospadias, Spina bifida, Patent urachus, Intrauterine growth retardation OMIM:192350
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Knobloch Syndrome 1
Occipital meningocele, Occipital encephalocele, Spina bifida occulta OMIM:267750
Marfan Syndrome
Meningocele ORPHA:558
Arima Syndrome
Occipital meningocele OMIM:243910
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Small scrotum, Hypospadias, Cryptorchidism, Anteriorly displaced genitalia, Aplasia of the uterus... OMIM:276820
Alazami Syndrome
Retractile testis OMIM:615071
Alazami Syndrome
ORPHA:319671

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Larp7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Larp7.

No publications found that use IMPC mice or data for Larp7.

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MGI Allele Allele Type Produced
Larp7tm1dIcs Deletion allele (post-Flp and Cre with no reporter) Mice
Larp7tm1aIcs KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells
Larp7tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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