Gene: Tbr1

Order

Name T-box brain gene 1

Status ES CellsMice
tm1b
Mice
tm1
phenotype data available

Links MGI:107404    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Tbr1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Tbr1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Tbr1tm1b(KOMP)Mbp HOM Female Male n/a 0.0
decreased circulating glucose level Tbr1tm1b(KOMP)Mbp HET Female Male postnatal 2.37E-8
increased prepulse inhibition Tbr1tm1b(KOMP)Mbp HET Female Male postnatal 9.14E-6
decreased blood urea nitrogen level Tbr1tm1b(KOMP)Mbp HET Female postnatal 9.87E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Blood 2 No
Bone marrow 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cecum 2 No (12/383)
Cerebellum 2 No
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127)
Diaphragm 2 No
Duodenum 2 No (2/127)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Gonadal fat pad 2 No
Harderian gland 2 No
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127)
Jejunum 2 No (6/127)
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Parotid gland 2 No
Penis 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Tongue 2 No (5/127)
Trachea 2 No
Trigeminal V nerve 2 No
Urinary bladder 2 No
Uterus 2 No
Vagina 2 No
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse nervous system reproductive system exocrine system trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 3 (1/51)
Brain 3 (6/485) (6/6)
Central nervous system ganglion 3 (1/51)
Dorsal root ganglion 3 (1/47)
Ear 3 (1/485)
Embryo 3 (1/485) (6/6)
Eye 3 (1/485)
Foot 3 (1/485)
Forebrain 3 (1/485) (6/6)
Forelimb 3 (1/485)
Fronto-nasal process 3 (1/48)
Gut 3 (1/50) (1/6)
Hand 3 (1/485)
Head 3 (5/485)
Head mesenchyme 3 (1/47)
Heart 3 (1/485)
Hindbrain 3 (6/485)
Hindlimb 3 (1/485)
Liver 3 (1/485)
Lung 3 (1/485)
Mandibular process 3 (1/485)
Maxillary process 3 (1/485) (1/6)
Midbrain 3 (1/485)
Nasal septum 3 (1/47)
Nose 3 (1/51)
Notochord 3 (1/47)
Oral cavity 3 (1/485)
Skeleton 3 (1/51)
Skin 3 (1/485)
Spinal cord 3 (1/50)
Tail 3 (1/485)
Tail somite 3 (1/485) (1/6)
Trunk mesenchyme 3 (1/47)
Vibrissa 3 (1/47)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • X-ray: XRay Images Dorso Ventral
    11 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Tbr1tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Tbr1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Tbr1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene