Gene: Gfm1

Order

Name G elongation factor, mitochondrial 1

Synonyms D3Wsu133e

Status ES CellsMice
tm1a
phenotype data available

Links MGI:107339    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Gfm1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Gfm1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Bone marrow - hyperplasia Gfm1tm1a(EUCOMM)Wtsi HET Male postnatal 0.0
Spleen - hyperplasia Gfm1tm1a(EUCOMM)Wtsi HET Male postnatal 0.0
Spleen - MPATH diagnostic term extramedullary hemopoiesis Gfm1tm1a(EUCOMM)Wtsi HET Male postnatal 0.0
preweaning lethality, complete penetrance Gfm1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (2/2)
Lung 2 No
Lymph node 2 No (2/2)
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (1/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No (1/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system immune system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (24)
  • Gfm1tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    bone, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI

show all 24 images

trunk (15)
  • Gfm1tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Female, WTSI

show all 15 images

digestive system (4)
  • Gfm1tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    stomach, oesophagus, HET, Male, WTSI
immune system (4)
  • Gfm1tm1a(EUCOMM)Wtsi
    mesenteric lymph node, lymph node, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
nervous system (4)
  • Gfm1tm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    pituitary gland, peripheral nervous system, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
integumental system (3)
  • Gfm1tm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    skin muscle, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    cartilage tissue, skin, HET, Female, WTSI
endocrine system (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
musculoskeletal system (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    bone, HET, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
reproductive system (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    uterus, ovary, oviduct, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
respiratory system (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
urinary system (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
cardiovascular system (1)
  • Gfm1tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
sensory organ (1)
  • Gfm1tm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI
set of connective tissues (1)
  • Gfm1tm1a(EUCOMM)Wtsi
    cartilage tissue, skin, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (251)
  • Gfm1tm1a(EUCOMM)Wtsi
    forearm, WT, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI

show all 251 images

Eye Morphology (3)
  • Gfm1tm1a(EUCOMM)Wtsi
    eye, synechia, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    eye, corneal opacity, narrow eye opening, abnormal placement of pupils, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    eye, cataracts, persistence of hyaloid vascular system, HET, Female, WTSI
Skin Histopathology (2)
  • Gfm1tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Gfm1tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Gfm1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene