Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased locomotor activity | Tsg101tm1b(EUCOMM)Hmgu | HET | Early adult | 1.17×10-05 | ||
preweaning lethality, complete penetrance | Tsg101tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
abnormal kidney morphology | Tsg101tm1b(EUCOMM)Hmgu | HET | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Tsg101 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Fanconi Anemia, Complementation Group C | Intrauterine growth retardation, Prolonged G2 phase of cell cycle | OMIM:227645 | |
Fanconi Anemia, Complementation Group E | Prolonged G2 phase of cell cycle | OMIM:600901 | |
Fanconi Anemia, Complementation Group A | Prolonged G2 phase of cell cycle | OMIM:227650 | |
Fanconi Anemia, Complementation Group D2 | Prolonged G2 phase of cell cycle | OMIM:227646 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Tsg101tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
Tsg101tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Tsg101tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Tsg101tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
Tsg101tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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