Gene: Cxcr2

Name chemokine (C-X-C motif) receptor 2

Synonyms
  • Il8rb
  • CD128
  • Cmkar2
  • IL8RA
  • IL-8rb
  • IL-8Rh
  • Gpcr16

Status ES CellsMice
tm1a
phenotype data available

Links MGI:105303   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Cxcr2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cxcr2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased B cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, alpha-beta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased immature B cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased mature B cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased pre-B cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased pre-pro B cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD103-positive CD11b-low dendritic cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1+ CD8 alpha beta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased Ly6C high monocyte number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased Ly6C low monocyte number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD4-positive, alpha-beta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD8-positive, alpha-beta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory T-helper cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased eosinophil cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased gamma-delta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased granulocyte number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory-marker CD4-positive NK T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory-marker NK cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory-marker gamma-delta T cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased monocyte cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased neutrophil cell number Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.0E-7
increased circulating calcium level Cxcr2tm1a(EUCOMM)Wtsi HOM Female postnatal 4.86E-7
increased circulating creatinine level Cxcr2tm1a(EUCOMM)Wtsi HET Female postnatal 1.97E-6
increased circulating magnesium level Cxcr2tm1a(EUCOMM)Wtsi HET Female Male postnatal 2.21E-5
increased circulating total protein level Cxcr2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.46E-5
decreased circulating thyroxine level Cxcr2tm1a(EUCOMM)Wtsi HOM Female postnatal 6.76E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    76 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    25 Images
  • X-ray: XRay Images Lateral Orientation
    50 Images
  • X-ray: XRay Images Forepaw
    26 Images
  • X-ray: XRay Images Skull Lateral Orientation
    25 Images
  • DSS Histology
    8 Images
  • Anti-nuclear antibody assay
    17 Images
Legacy Phenotype Associated Images
Xray (126)
  • Cxcr2tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 126 images

Dysmorphology (6)
  • Cxcr2tm1a(EUCOMM)Wtsi
    HEAD, abnormal snout morphology, upturned snout, HET, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HEAD, abnormal snout morphology, asymmetric snout, HET, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HEAD, abnormal snout morphology, asymmetric snout, HET, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    HEAD, abnormal snout morphology, upturned snout, HET, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal snout morphology, HEAD, asymmetric snout, malocclusion, HET, Male, WTSI

show all 6 images

Eye Morphology (5)
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal pupil morphology, HET, Female, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI
  • Cxcr2tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cxcr2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene