Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to P2ry2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Hypocalcemia, Autosomal Dominant 2 | Abnormal blood phosphate concentration, Hypocalcemia | OMIM:615361 | |
Colchicine Poisoning | Hyponatremia, Abnormal blood ion concentration, Hypophosphatemia, Hypokalemia, Hypocalcemia, Hypo... | ORPHA:31824 | |
Cholera | Hyponatremia, Hypocalcemia, Hypokalemia, Abnormal blood ion concentration | ORPHA:173 | |
Infantile Nephropathic Cystinosis | Hypokalemia, Abnormal blood ion concentration, Hypophosphatemia | ORPHA:411629 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to P2ry2.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. | Proceedings of the National Academy of Sciences of the United States of America (January 2020) | P2ry2tm1c(EUCOMM)Hmgu | 31896584 |
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. | The Journal of clinical investigation (October 2016) | P2ry2tm1c(EUCOMM)Hmgu | PMC5127677 |
P2Yā and Gq/Gāā control blood pressure by mediating endothelial mechanotransduction. | The Journal of clinical investigation (July 2015) | P2ry2tm1c(EUCOMM)Hmgu P2ry2tm1a(EUCOMM)Hmgu | PMC4563756 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
P2ry2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
P2ry2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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