Gene: Gclc

Order

Name glutamate-cysteine ligase, catalytic subunit

Synonyms
  • GLCL-H
  • gamma GCS-HS
  • Glclc
  • D9Wsu168e

Status ES CellsMice
tm1a
phenotype data available

Links MGI:104990    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Gclc

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Gclc data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Liver - lipid deposition Gclctm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
Ovary - hyperplasia Gclctm1a(EUCOMM)Wtsi HOM Female postnatal 0.0
increased body weight Gclctm1a(EUCOMM)Wtsi HOM Female Male postnatal 7.21E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No (2/2)
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (25)
  • Gclctm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI

show all 25 images

trunk (16)
  • Gclctm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI

show all 16 images

digestive system (4)
  • Gclctm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    large intestine, HET, Male, WTSI
immune system (4)
  • Gclctm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
nervous system (4)
  • Gclctm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    peripheral nervous system, pituitary gland, HET, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
cardiovascular system (3)
  • Gclctm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    cartilage tissue, skeletal muscle tissue, blood vessel, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    blood vessel, cartilage tissue, skeletal muscle tissue, HET, Female, WTSI
reproductive system (3)
  • Gclctm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    uterus, ovary, oviduct, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    prostate gland, HET, Male, WTSI
endocrine system (2)
  • Gclctm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    adrenal gland, HET, Male, WTSI
musculoskeletal system (2)
  • Gclctm1a(EUCOMM)Wtsi
    cartilage tissue, skeletal muscle tissue, blood vessel, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    blood vessel, cartilage tissue, skeletal muscle tissue, HET, Female, WTSI
respiratory system (2)
  • Gclctm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Male, WTSI
sensory organ (2)
  • Gclctm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI
set of connective tissues (2)
  • Gclctm1a(EUCOMM)Wtsi
    cartilage tissue, skeletal muscle tissue, blood vessel, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    blood vessel, cartilage tissue, skeletal muscle tissue, HET, Female, WTSI
urinary system (2)
  • Gclctm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Female, WTSI
exocrine system (1)
  • Gclctm1a(EUCOMM)Wtsi
    prostate gland, HET, Male, WTSI
integumental system (1)
  • Gclctm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (67)
  • Gclctm1a(EUCOMM)Wtsi
    head, HOM, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    head, HOM, Male, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI

show all 67 images

Skin Histopathology (2)
  • Gclctm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Gclctm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Gclctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene