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Gene: Plcb3 MGI:104778

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
phospholipase C, beta 3
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plcb3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Plcb3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spondylometaphyseal Dysplasia With Corneal Dystrophy
OMIM:618961

The table below shows human diseases predicted to be associated to Plcb3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nevus Comedonicus
Nevus comedonicus OMIM:617025
Capillary Malformations, Congenital
Nevus flammeus OMIM:163000
Knuckle Pads
Subcutaneous nodule OMIM:149100
Rheumatoid Nodulosis
Subcutaneous nodule OMIM:180350
Milia, Multiple Eruptive
Milia OMIM:157400
Elastosis Perforans Serpiginosa
Nevus OMIM:130100
Proliferating Trichilemmal Cyst
Epidermoid cyst, Skin ulcer ORPHA:492
Dyschromatosis Universalis Hereditaria 3
Hypopigmented macule, Hypermelanotic macule OMIM:615402
Nevus, Epidermal
Numerous nevi, Melanocytic nevus OMIM:162900
Non-Epidermolytic Palmoplantar Keratoderma
Papule, Erythema, Skin ulcer ORPHA:2337
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Dermatofibrosarcoma Protuberans
Subcutaneous nodule, Erythema, Skin ulcer ORPHA:31112
Aplasia Cutis Congenita Of Limbs, Autosomal Recessive
Aplasia cutis congenita, Congenital absence of skin of limbs OMIM:600360
Hyperkeratosis Lenticularis Perstans
Papule, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:409
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Necrobiosis Lipoidica
Indurated nodule, Skin nodule, Erythema, Skin ulcer, Atrophic scars, Annular cutaneous lesion, Sk... ORPHA:542592
Chilblain Lupus 1
Skin ulcer OMIM:610448
Aplasia Cutis Congenita
Aplasia cutis congenita over the scalp vertex, Skin ulcer, Congenital localized absence of skin ORPHA:1114
Juvenile Hyaline Fibromatosis
Subcutaneous nodule, Papule, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:2028
Aplasia Cutis-Myopia Syndrome
Aplasia cutis congenita, Skin ulcer ORPHA:1117
Familial Keratoacanthoma
Papule, Subcutaneous nodule, Skin ulcer ORPHA:493
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer, Purpura ORPHA:743
Buerger Disease
Skin ulcer ORPHA:36258
Neuropathy, Hereditary Sensory, Type Iic
Acral ulceration OMIM:614213
Dracunculiasis
Subcutaneous nodule, Skin ulcer ORPHA:231
Striae Distensae, Familial
Striae distensae OMIM:185200
Pruritic Urticarial Papules And Plaques Of Pregnancy
Striae distensae OMIM:178995
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Acrogeria
Excessive wrinkled skin, Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer ORPHA:2500
Classic Mycosis Fungoides
Erythema, Hypopigmented skin patches, Skin ulcer, Skin plaque, Dry skin ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Lichen Planopilaris
Dermal atrophy, Papule, Hypopigmented skin patches, Skin ulcer ORPHA:525
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Pyoderma Gangrenosum
Skin vesicle, Atrophic scars, Papule, Skin ulcer ORPHA:48104
Brooke-Spiegler Syndrome
Skin-colored papule, Skin nodule, Skin ulcer, Nodular changes affecting the eyelids ORPHA:79493
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous plaque, Erythematous papule, Skin ulcer ORPHA:86884
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Limited Cutaneous Systemic Sclerosis
Hypopigmented skin patches, Skin ulcer ORPHA:220402
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Familial Multiple Nevi Flammei
Nevus flammeus, Skin ulcer, Hypermelanotic macule, Papule ORPHA:624
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Leishmaniasis
Skin plaque, Skin ulcer, Pallor, Papule ORPHA:507
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Polyarteritis Nodosa
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:767
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Acquired Purpura Fulminans
Macule, Erythematous macule, Pyoderma gangrenosum, Macular purpura ORPHA:49566
Hereditary Sensory And Autonomic Neuropathy Type 1
Penetrating foot ulcers, Skin ulcer ORPHA:36386
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Dermatoosteolysis, Kirghizian Type
Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:1657
Prolidase Deficiency
Aplasia/Hypoplasia of the skin, Erythema, Skin ulcer, Thin skin, Dry skin, Papule ORPHA:742
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Calciphylaxis
Skin ulcer ORPHA:280062
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Papa Syndrome
Skin ulcer ORPHA:69126
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Meige Disease
Atypical scarring of skin, Skin erosion, Skin dimple, Skin ulcer ORPHA:90186
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Erythema, Skin ulcer, Skin fissure ORPHA:659
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Cryoglobulinemic Vasculitis
Petechiae, Skin ulcer, Purpura ORPHA:91138
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Acute Radiation Syndrome
Dermal atrophy, Scaling skin, Skin ulcer ORPHA:454831
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
X-Linked Agammaglobulinemia
Hypopigmented skin patches, Skin ulcer ORPHA:47
Neutrophilic Dermatosis, Acute Febrile
Erythema, Pyoderma gangrenosum OMIM:608068
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
Autosomal Dominant Hyper-Ige Syndrome
Skin vesicle, Skin ulcer, Papule ORPHA:2314
Adult Syndrome
Dry skin, Thin skin, Skin ulcer, Melanocytic nevus ORPHA:978
Chronic Granulomatous Disease
Macule, Hypermelanotic macule, Skin ulcer ORPHA:379
Chronic Mucocutaneous Candidiasis
Erythema, Skin ulcer, Papule ORPHA:1334
Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Acral ulceration OMIM:162400
Livedoid Vasculopathy
Skin ulcer, Atrophic scars, Macular purpura, Ecchymosis, Erythematous papule ORPHA:542643
Werner Syndrome
Aplasia/Hypoplasia of the skin, Lack of skin elasticity, Skin ulcer ORPHA:902
Reynolds Syndrome
Skin ulcer ORPHA:779
Microscopic Polyangiitis
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:727
Acrodermatitis Enteropathica
Erythema, Dry skin, Skin ulcer ORPHA:37
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Sweet Syndrome
Skin nodule, Pyoderma gangrenosum, Erythematous plaque, Skin vesicle, Erythematous papule ORPHA:3243
Hereditary Acrokeratotic Poikiloderma
Erythema, Hypopigmented skin patches, Skin ulcer, Thin skin, Papule ORPHA:2907
Malakoplakia
Subcutaneous nodule, Skin ulcer, Papule ORPHA:556
Fusariosis
Subcutaneous nodule, Skin ulcer, Skin detachment, Papule ORPHA:228119
Dyskeratosis Congenita
Macule, Aplasia/Hypoplasia of the skin, Hypermelanotic macule, Hypopigmented skin patches, Skin u... ORPHA:1775
Tumoral Calcinosis, Normophosphatemic, Familial
Calcinosis OMIM:610455
Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Acral ulceration OMIM:201300
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Giant Cell Arteritis
Skin ulcer ORPHA:397
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Juvenile Dermatomyositis
Erythema, Dry skin, Skin ulcer ORPHA:93672
Immunoglobulin A Vasculitis
Macule, Erythema, Skin ulcer, Purpura ORPHA:761
Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive
Acral ulceration OMIM:256840
Incontinentia Pigmenti
Erythema, Hypopigmented skin patches, Skin ulcer ORPHA:464
Toxic Epidermal Necrolysis
Macule, Erythema, Skin ulcer ORPHA:537
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Parkes Weber Syndrome
Erythematous plaque, Capillary malformation, Scaling skin, Skin ulcer ORPHA:90307
Systemic Sclerosis
Cutaneous sclerotic plaque, Digital pitting scar, Spotty hypopigmentation, Digital ulcer, Acral u... ORPHA:90291
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Pgm3-Cdg
Skin ulcer ORPHA:443811
Dermatomyositis
Aplasia/Hypoplasia of the skin, Erythema, Skin ulcer, Dry skin, Papule ORPHA:221
Blau Syndrome
Intermittent generalized erythematous papular rash, Skin ulcer OMIM:186580
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Skin ulcer, Papule ORPHA:68
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Subcutaneous nodule, Scaling skin, Skin ulcer ORPHA:2526
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Urticarial plaque, Skin ulcer, Purpura OMIM:615688
Leprosy
Urticarial plaque, Hypopigmented macule, Skin nodule, Penetrating foot ulcers, Verrucous papule, ... ORPHA:548
Hajdu-Cheney Syndrome
Dry skin, Skin ulcer ORPHA:955
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Chime Syndrome
Erythema, Skin ulcer ORPHA:3474
Wiskott-Aldrich Syndrome
Petechiae, Skin ulcer, Purpura ORPHA:906
Cushing Disease
Skin ulcer, Thin skin, Ecchymosis, Striae distensae, Purpura ORPHA:96253
Granulomatosis With Polyangiitis
Skin ulcer, Papule, Purpura ORPHA:900
Insensitivity To Pain, Congenital, With Anhidrosis
Acral ulceration OMIM:256800
Simple Cryoglobulinemia
Localized skin lesion, Acral ulceration, Purpura ORPHA:91139
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Primary Sjögren Syndrome
Dry skin, Lichenoid skin lesion, Skin ulcer, Purpura ORPHA:289390
Blau Syndrome
Erythema, Dry skin, Skin ulcer, Papule ORPHA:90340
Atypical Werner Syndrome
Aplasia/Hypoplasia of the skin, Thin skin, Skin ulcer, Lack of skin elasticity ORPHA:79474
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Ecchymosis, Skin ulcer ORPHA:2072
Chronic Graft Versus Host Disease
Skin vesicle, Erythema, Intermittent generalized erythematous papular rash, Skin ulcer ORPHA:99921
Plague
Localized skin lesion, Dry skin, Skin ulcer ORPHA:707
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Acral ulceration OMIM:256810
Cushing Syndrome Due To Ectopic Acth Secretion
Skin ulcer, Thin skin, Ecchymosis, Striae distensae, Purpura ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Split Cord Malformation
Skin dimple, Penetrating foot ulcers ORPHA:573278
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Spondylometaphyseal Dysplasia With Corneal Dystrophy
OMIM:618961

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plcb3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plcb3.

No publications found that use IMPC mice or data for Plcb3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Plcb3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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