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Gene: Capzb

Order

Name capping protein (actin filament) muscle Z-line, beta

Synonyms

Cappb1
CPB2
CPbeta1
CPB1
CPbeta2
1700120C01Rik

Status ES Cells Mice
tm1a phenotype data available

Links MGI:104652 Ensembl Gene Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Capzb

Significant Not Significant Not tested

All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Capzb data for that phenotype.

All Data: Capzb Measurements Heatmap / Table

Significant Phenotypes

System	Phenotype	Allele	Zyg	Sex	Life Stage	P Value	Data
	preweaning lethality, complete penetrance	Capzb^{tm1a(EUCOMM)Wtsi}	HOM		n/a	0.0

Download data as: TSV XLS

Expression

Show expression table

Expression No Expression No Tissue Available Ambiguous

Show Wildtype Expression

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr
Adrenal gland	2	No
Aorta	2	No	(1/562)
Blood vessel	2	No
Bone	2	No	(1/539)
Brain	2	No	(6/562)	(2/2)
Brainstem	2	No	(4/562)
Brown adipose tissue	2	No
Cartilage tissue	2	No	(1/562)
Cerebellum	2	No	(4/562)
Cerebral cortex	2	No	(5/562)
Eye	2	No	(1/562)
Gall bladder	2	No
Heart	2	No	(3/562)	(2/2)
Hippocampus	2	No	(5/562)
Hypothalamus	2	No	(4/562)
Kidney	2	No	(20/562)
Large intestine	2	No	(12/562)
Liver	2	No
Lower urinary tract	2	No	(3/562)
Lung	2	No	(3/562)	(2/2)
Lymph node	2	No	(1/562)
Mammary gland	2	No
Esophagus	2	No
Olfactory lobe	2	No
Ovary	2	No	(1/562)
Oviduct	2	No	(2/562)	(1/2)
Pancreas	2	No	(6/562)
Parathyroid gland	2	No	(2/540)
Peripheral nervous system	2	No	(3/562)
Peyer's patch	2	No
Pituitary gland	2	No	(1/562)
Prostate gland	2	No	(5/562)
Skeletal muscle tissue	2	No
Skin	2	No	(1/562)	(2/2)
Small intestine	2	No	(11/562)
Spinal cord	2	No	(3/562)
Spleen	2	No	(4/562)
Stomach	2	No	(9/562)	(2/2)
Striatum	2	No	(4/562)
Testis	2	No	(4/562)	(1/2)
Thymus	2	No
Thyroid gland	2	No	(16/562)	(1/2)
Trachea	2	No	(3/562)
Uterus	2	No	(2/562)
White adipose tissue	2	No

Expression in Anatomogram

Tissues/organs lacZ+ expression

postnatal mouse

respiratory system

endocrine system

digestive system

cardiovascular system

nervous system

reproductive system

integumental system

trunk

No expression image was found for this adult tab

No expression data was found for this embryo tab

Secondary lacZ Expression Data

trunk (5)

Capzb^{tm1a(EUCOMM)Wtsi}
TESTIS, HET, Male, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
HEART, HET, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
LUNG, HET, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
STOMACH, HET, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
OVIDUCT, HET, Female, WTSI

reproductive system (2)

Capzb^{tm1a(EUCOMM)Wtsi}
TESTIS, HET, Male, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
OVIDUCT, HET, Female, WTSI

cardiovascular system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
HEART, HET, Female, WTSI

digestive system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
STOMACH, HET, Female, WTSI

endocrine system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
THYROID GLAND, HET, Male, WTSI

integumental system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
SKIN, AURICLE, HET, Male, WTSI

nervous system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
BRAIN, HET, Female, WTSI

respiratory system (1)

Capzb^{tm1a(EUCOMM)Wtsi}
LUNG, HET, Female, WTSI

sensory organ (1)

Capzb^{tm1a(EUCOMM)Wtsi}
SKIN, AURICLE, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images

Xray (76)

Capzb^{tm1a(EUCOMM)Wtsi}
HEAD, WT, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
LOWER ARM, WT, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
TRUNK, WT, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
TRUNK, WT, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
HEAD, WT, Female, WTSI

show all 76 images

Skin Histopathology (3)

Capzb^{tm1a(EUCOMM)Wtsi}
FOOT DIGIT 4, HET, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
FOOT DIGIT 4, HET, Female, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
FOOT DIGIT 4, HET, Female, WTSI

Eye Morphology (2)

Capzb^{tm1a(EUCOMM)Wtsi}
EYE, abnormal retinal pigmentation, HET, Male, WTSI
Capzb^{tm1a(EUCOMM)Wtsi}
EYE, abnormal retinal blood vessel pattern, HET, Male, WTSI

Disease Models

By annotation and orthology
By phenotypic similarity

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail

Product Ordering

MGI Allele

Allele Type

Type Map Seq

Vector

ES Cell

Mouse

Tissue Enquiry

Capzb^{tm1a(EUCOMM)Wtsi}

KO first allele (reporter-tagged insertion with conditional potential)

Vector
Gene