Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | Wholemount images | heterozygote | 50% (2 of 4) |
Cerebellum | Wholemount images | heterozygote | 50% (2 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Liver | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Lung | Wholemount images | heterozygote | 50% (2 of 4) |
Mesenteric adipose tissue | Wholemount images | heterozygote | 50% (2 of 4) |
Midbrain | Wholemount images | heterozygote | 50% (2 of 4) |
Olfactory lobe | Wholemount images | heterozygote | 50% (2 of 4) |
Oviduct | Wholemount images | heterozygote | 25% (1 of 4) |
Pancreas | Wholemount images | heterozygote | 50% (2 of 4) |
Prostate gland | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Spinal cord | Wholemount images | heterozygote | 50% (2 of 4) |
Spleen | Wholemount images | heterozygote | 25% (1 of 4) |
Sublingual gland | Section images | heterozygote | 25% (1 of 4) |
Submandibular gland | Section images | heterozygote | 50% (2 of 4) |
Thymus | Wholemount images | heterozygote | 50% (2 of 4) |
Tongue | Wholemount images | heterozygote | 50% (2 of 4) |
Urinary bladder | Wholemount images | heterozygote | 25% (1 of 4) |
Uterus | Wholemount images | heterozygote | 25% (1 of 4) |
Vas deferens | Section images | heterozygote | 25% (1 of 4) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 4) |
Aorta | N/A | heterozygote | 0.0% (0 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cartilage tissue | N/A | heterozygote | Not available |
Cecum | N/A | heterozygote | 50% (2 of 4) |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Colon | N/A | heterozygote | 50% (2 of 4) |
Diaphragm | N/A | heterozygote | 0.0% (0 of 4) |
Duodenum | N/A | heterozygote | 0.0% (0 of 4) |
Esophagus | N/A | heterozygote | 0.0% (0 of 4) |
Eye | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Harderian gland | N/A | heterozygote | 0.0% (0 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Ileum | N/A | heterozygote | 50% (2 of 4) |
Jejunum | N/A | heterozygote | 50% (2 of 4) |
Kidney | N/A | heterozygote | 25% (1 of 4) |
Large intestine | N/A | heterozygote | 50% (2 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Parathyroid gland | N/A | heterozygote | Not available |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Penis | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 4) |
Quadriceps | N/A | heterozygote | 0.0% (0 of 4) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Skin | N/A | heterozygote | 0.0% (0 of 4) |
Small intestine | N/A | heterozygote | 50% (2 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Stomach | N/A | heterozygote | 0.0% (0 of 4) |
Striatum | N/A | heterozygote | Not available |
Testis | N/A | heterozygote | 0.0% (0 of 4) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 4) |
Trachea | N/A | heterozygote | 0.0% (0 of 4) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 4) |
Vagina | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
Vesicular gland | N/A | heterozygote | 0.0% (0 of 4) |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Apof by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Apof.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. | PLoS genetics (February 2016) | Apoftm1(KOMP)Vlcg | PMC4739719 |
The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. | PloS one (February 2012) | Apoftm1(KOMP)Vlcg | PMC3282742 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Apoftm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Apoftm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Apoftm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Apoftm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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