Gene: Acvr2a

Name activin receptor IIA

Synonyms
  • Acvr2
  • tActRII
  • ActRIIa

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:102806   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Acvr2a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Acvr2a data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Acvr2atm1.1(KOMP)Vlcg HOM Male embryonic day 15.5 0.0
abnormal embryo size Acvr2atm1.1(KOMP)Vlcg HOM Male embryonic day 15.5 0.0
anophthalmia Acvr2atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
microphthalmia Acvr2atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
preweaning lethality, incomplete penetrance Acvr2atm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
abnormal bone structure Acvr2atm1.1(KOMP)Vlcg HOM Female Male postnatal 4.87E-5
abnormal bone structure Acvr2atm1.1(KOMP)Vlcg HET Female Male postnatal 4.87E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354)
Aorta 2 No (2/530) (2/2)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Cartilage tissue 2 No (1/530)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354)
Eye 2 No (1/530) (2/2)
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530)
Hypothalamus 2 No (5/529)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530)
Peripheral nervous system 2 No (4/530)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530)
Prostate gland 2 No (3/530) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/530) (2/2)
Small intestine 2 No (5/530) (2/2)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530)
Testis 2 No (7/530)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530)
Uterus 2 No (1/530) (1/2)
Vascular system 2 No (1/354)
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 4 (5/413) Image Only
Ear 4 Image Only
Embryo 4 Image Only
Eye 4 Image Only
Foot 4 Image Only
Forebrain 4 Image Only
Forelimb 4 Image Only
Hand 4 Image Only
Head 4 (4/413) Image Only
Heart 4 Image Only
Hindbrain 4 (5/413) Image Only
Hindlimb 4 Image Only
Liver 4 Image Only
Lung 4 Image Only
Mandibular process 4 Image Only
Maxillary process 4 Image Only
Midbrain 4 Image Only
Oral cavity 4 Image Only
Skin 4 Image Only
Tail 4 Image Only
Tail somite 4 Image Only


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Section
    18 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • Gross Pathology and Tissue Collection
    12 Images
  • Eye Morphology: Images Slit Lamp
    3 Images
  • X-ray: XRay Images Dorso Ventral
    14 Images
  • X-ray: XRay Images Lateral Orientation
    14 Images
  • Combined SHIRPA and Dysmorphology
    1 Images
  • Eye Morphology: Images Ophthalmoscopy
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Acvr2atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Acvr2atm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Acvr2atm270449(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Acvr2atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Acvr2atm378905(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene