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Gene: Ccnf MGI:102551

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cyclin F
Synonyms:
Fbxo1,  CycF

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ccnf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ccnf by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Amyotrophic Lateral Sclerosis
ORPHA:803
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 5
OMIM:619141

The table below shows human diseases predicted to be associated to Ccnf by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Hydrolethalus Syndrome 2
Hydrocephalus, Postaxial hand polydactyly, Anencephaly, Postaxial foot polydactyly, Molar tooth s... OMIM:614120
Joubert Syndrome 15
Molar tooth sign on MRI, Preaxial polydactyly, Exencephaly OMIM:614464
Blepharocheilodontic Syndrome 1
Neural tube defect, Clinodactyly, Cutaneous syndactyly OMIM:119580
Alg3-Cdg
Hypoplasia of the pons, Neural tube defect, Abnormal limb bone morphology, Metaphyseal chondrodys... ORPHA:79321
Meckel Syndrome, Type 4
Encephalocele, Bowing of the long bones, Hydrocephalus, Meningocele, Anencephaly, Postaxial hand ... OMIM:611134
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Fanconi Anemia, Complementation Group D2
Absent thumb, Absent radius, Preaxial hand polydactyly, Short thumb, Hydrocephalus, Partial dupli... OMIM:227646
Iniencephaly
Encephalocele, Rhizomelia, Rocker bottom foot, Spina bifida, Hydrocephalus, Myelomeningocele, Ane... ORPHA:63259
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Bilateral talipes... OMIM:600145
Fanconi Anemia, Complementation Group C
Absent thumb, Absent radius, Short thumb, Prolonged G2 phase of cell cycle, Complete duplication ... OMIM:227645
Fanconi Anemia, Complementation Group E
Absent thumb, Absent radius, Short thumb, Prolonged G2 phase of cell cycle, Complete duplication ... OMIM:600901
Fanconi Anemia, Complementation Group A
Absent thumb, Absent radius, Short thumb, Prolonged G2 phase of cell cycle, Complete duplication ... OMIM:227650
Semilobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal brainstem morphology ORPHA:220386
Alobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal brainstem morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal brainstem morphology ORPHA:93926
Lobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal brainstem morphology ORPHA:93924
Schinzel-Giedion Syndrome
Overlapping fingers, Overlapping toe, Tibial bowing, Neural tube defect, Radioulnar synostosis, C... ORPHA:798
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 5
OMIM:619141
Amyotrophic Lateral Sclerosis
ORPHA:803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ccnf

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ccnf.

No publications found that use IMPC mice or data for Ccnf.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ccnftm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ccnftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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