All nervous system phenotype, behavior/neurological phenotype data for Acat2

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status Graph
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Responsive to tactile stimuli HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Responsive to tactile stimuli HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Responsive to tactile stimuli HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Responsive to tactile stimuli HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Holoprosencephaly HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Holoprosencephaly HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Holoprosencephaly HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Holoprosencephaly HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Center permanence time HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.85112 Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Whole arena resting time HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withWeight 0.82835 Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Activity (body position) HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Head bobbing HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Trunk curl HET 9f:10m Fisher Exact Test framework 1.0000 Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / spina bifida HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / spina bifida HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / spina bifida HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / spina bifida HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Eye Morphology / Optic Disc HET 7f:10m Fisher Exact Test framework 0.0044386 Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Midbrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Midbrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Midbrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Midbrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Contact righting HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Exencephaly HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Exencephaly HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Exencephaly HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Exencephaly HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Distance travelled - total HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withWeight 0.46105 Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Spontaneous movement HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Spontaneous movement HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Spontaneous movement HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E18.5 / Spontaneous movement HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Number of rears - total HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.86272 Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Unexpected behaviors HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Open Field / Periphery permanence time HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.46260 Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Gait HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Neural Tube Closure HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Neural Tube Closure HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Neural Tube Closure HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Neural Tube Closure HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Forebrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Forebrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Forebrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Forebrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Aggression HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Tremor HET 9f:10m Fisher Exact Test framework 0.075028 Success
Acat2tm1b(KOMP)Wtsi BCM Grip Strength / Forelimb grip strength measurement mean HET 6f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.38480 Success
Acat2tm1b(KOMP)Wtsi BCM Grip Strength / Forelimb grip strength measurement mean HET 3f:5m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_GRS_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Startle response HET 9f:10m Fisher Exact Test framework 1.0000 Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Limb grasp HET 9f:10m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Acat2tm1b(KOMP)Wtsi BCM Open Field / Whole arena average speed HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.87680 Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Hindbrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Hindbrain morphology HOM f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Hindbrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Gross Morphology Embryo E12.5 / Hindbrain morphology HET f:m Supplied as data Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Center distance travelled HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.90583 Success
Acat2tm1b(KOMP)Wtsi BCM Combined SHIRPA and Dysmorphology / Vocalization HET 9f:10m Fisher Exact Test framework 1.0000 Success
Acat2tm1b(KOMP)Wtsi BCM Open Field / Periphery distance travelled HET 9f:10m Mixed Model framework, linear mixed-effects model, equation withWeight 0.25016 Success
Acat2tm1b(KOMP)Wtsi BCM Grip Strength / Forelimb and hindlimb grip strength measurement mean HET 6f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.57583 Success
Acat2tm1b(KOMP)Wtsi BCM Grip Strength / Forelimb and hindlimb grip strength measurement mean HET 3f:5m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_GRS_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.

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