Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - thickness
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - thickness
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - back
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - back
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Bulging eye
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Bulging eye
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris/Pupil
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
6.91×10-06
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris/Pupil
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
0.0336
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cartilage tissue
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell hemoglobin concentration
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell hemoglobin concentration
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.000129
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Striatum
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / B2 Immature + MZB
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Monocytes
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fibula
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fibula
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of vertebrae
|
HET
|
6f:5m
|
Fisher Exact Test framework
|
0.0281
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of vertebrae
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 6kHz-evoked ABR Threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0308
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 6kHz-evoked ABR Threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0760
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Viability E18.5 Secondary Screen / Outcome
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Peyers Patch
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Small Intestine
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / T/NKT/B1
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens Opacity
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens Opacity
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - back paws
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - back paws
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - shape
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - shape
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00838
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lymph Node
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Zygomatic bone
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Zygomatic bone
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Spleen weight
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Calcium
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Calcium
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.434
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / HR
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / HR
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.901
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center movement time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center movement time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.404
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of ribs
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00445
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of ribs
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Number of signals
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Number of signals
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - ear
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - ear
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - number
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - number
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.885
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Body weight
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.277
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Potassium
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Potassium
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.497
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.870
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 30kHz-evoked ABR Threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0174
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 30kHz-evoked ABR Threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.122
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Phosphorus
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Phosphorus
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.165
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - shape
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - morphology
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - morphology
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Viability Primary Screen / Viability Outcome
|
HOM
|
f:m
|
Supplied as data
|
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.365
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.178
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head morphology
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head morphology
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / ST
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / ST
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.347
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal vascularization
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00530
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal vascularization
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD8 Resting
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Pattern
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Pattern
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Triglycerides
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Triglycerides
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.762
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / B2 Total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Platelet count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Platelet count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.198
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Macrophages
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD8 Naive
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Thymus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Skeletal Muscle
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Position
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.000202
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Position
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - position
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - position
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Peripheral Nervous System
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Latency to center entry
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Latency to center entry
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.398
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Mammary gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of vertebrae
|
HET
|
6f:5m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of vertebrae
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
0.0132
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - morphology
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
0.0447
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - morphology
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - abdomen
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - abdomen
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Tregs
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.762
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Adrenal gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QTc
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QTc
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.000262
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head size
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00213
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head size
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.245
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Sodium
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Sodium
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - shape
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - shape
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Alive
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Alive
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull)
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull)
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.00526
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Number of live cells acquired Panel 1
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil differential count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.128
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - snout
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - snout
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Trachea
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / HDL-cholesterol
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / HDL-cholesterol
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.148
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Persistence of hyaloid vascular system
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Persistence of hyaloid vascular system
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
0.172
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.338
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cerebral Cortex
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Processes on vertebrae
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Processes on vertebrae
|
HET
|
6f:5m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Maxilla/Pre-maxilla
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
3.12×10-05
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Maxilla/Pre-maxilla
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte differential count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.000777
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Viability E12.5 Secondary Screen / Outcome
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Mouth morphology
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Mouth morphology
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Testis
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Kidney
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head bobbing
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head bobbing
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Pituitary gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs right
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs right
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / rMSSD
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / rMSSD
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
8.74×10-09
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - ear
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - ear
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Body weight
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed series
|
HET
|
31f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alpha-amylase
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alpha-amylase
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.00377
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PR
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PR
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0730
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD8 Effector
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Iron
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Iron
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.00848
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.210
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - length
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - length
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Total cell count in spleen
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWd
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWd
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.418
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Aggression
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Aggression
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Number of center entries
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Number of center entries
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.235
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement mean
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement mean
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.00135
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Olfactory Lobe
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Startle response
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Startle response
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - shape
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Tregs Effector
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - BN
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - BN
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWs
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWs
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.0944
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Femur
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Femur
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Cornea
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00303
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Cornea
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 12kHz-evoked ABR Threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0308
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 12kHz-evoked ABR Threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.104
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / gd + B1
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
1.58×10-08
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull)
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull)
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0169
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Ejection Fraction
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Ejection Fraction
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.544
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.193
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / LIH (Hemolysis Severity - available on AU analysers)
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / LIH (Hemolysis Severity - available on AU analysers)
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - tail
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - tail
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris Pigmentation
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris Pigmentation
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - appearance
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - appearance
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / B2 Mature
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Right kidney
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Right kidney
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.816
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil cell count
|
HET
|
8f:7m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.651
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Humerus
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Humerus
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Limb grasp
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Limb grasp
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cerebellum
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN)
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN)
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.394
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - head
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - head
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0265
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean R amplitude
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean R amplitude
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - presence
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - presence
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Ulna
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Ulna
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Spleen weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Spleen weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.420
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - number
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - number
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - length
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - length
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Unexpected behaviors
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Unexpected behaviors
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.605
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs left
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs left
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - front paws
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - front paws
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Area
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Area
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0137
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Vascular System
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QT
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QT
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.359
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDs
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDs
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.956
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Cardiac Output
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Cardiac Output
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.148
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Pigmentation
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Pigmentation
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD4 T cells total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Liver
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Gall Bladder
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Stomach
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - position
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - position
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3_S
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - front paws
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - front paws
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil differential count
|
HET
|
8f:7m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
4.53×10-19
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - abdomen
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - abdomen
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2_S
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Hippocampus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Glucose
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Glucose
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.208
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Fertility of Homozygous Knock-out Mice / Gross Findings Female
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / iNKT
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Skull shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.0148
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Skull shape
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
0.0972
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Fractional Shortening
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Fractional Shortening
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.512
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - number
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - number
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Spinal cord
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QRS
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QRS
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.956
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - number
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - number
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - presence
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - presence
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Chloride
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Chloride
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.925
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean mass
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean mass
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0499
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Light Response
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00303
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Light Response
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
0.0344
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal opacity
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00163
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal opacity
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Prostate gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Left kidney
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Left kidney
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.678
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / White blood cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / White blood cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.561
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alanine aminotransferase
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alanine aminotransferase
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.155
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Ophthalmoscope Observation
|
HET
|
f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWd
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWd
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.00638
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - shape
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - shape
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / RR
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / RR
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.400
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - whole body
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - whole body
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatinine
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatinine
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.366
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Radius
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Radius
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.311
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean platelet volume
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean platelet volume
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.475
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil differential count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00270
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWs
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWs
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.485
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Brachydactyly
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Brachydactyly
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Number of live cells acquired Panel 2
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - presence
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - presence
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower teeth appearance
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower teeth appearance
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Scapulae
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
5.37×10-05
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Scapulae
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Parathyroid gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Structure
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Structure
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Skin
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD4 Resting/Naive
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Esophagus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina (combined)
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Body weight
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Pancreas
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Contact righting
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Contact righting
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hematocrit
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hematocrit
|
HET
|
8f:7m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.0549
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - head
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - head
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatine kinase
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatine kinase
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.696
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - abdomen
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - abdomen
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1_S
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Tregs Resting
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Hypothalamus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Dilation
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00228
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Dilation
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat mass
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat mass
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.117
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / NK Total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tremor
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tremor
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Diastolic Diameter
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Diastolic Diameter
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.0788
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper teeth appearance
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper teeth appearance
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Body Weight
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Body Weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.296
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Eye
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 18kHz-evoked ABR Threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0141
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 18kHz-evoked ABR Threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean SR amplitude
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean SR amplitude
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Thyroid gland
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Clavicle
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Clavicle
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight curve
|
HOM
|
f:34m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight curve
|
HET
|
124f:125m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PQ
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PQ
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0538
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Activity (body position)
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Activity (body position)
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Heart
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - size
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - size
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Digit integrity
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Digit integrity
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Slit Lamp observation
|
HOM
|
f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - snout
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - snout
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total protein
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total protein
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.192
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Respiration Rate
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Respiration Rate
|
HET
|
7f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.555
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat/Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat/Body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.233
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid closure
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid closure
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Oviduct
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD4 Effector
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDd
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDd
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.00582
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Aspartate aminotransferase
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Aspartate aminotransferase
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.730
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - length
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - length
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Bone
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0577
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vocalization
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vocalization
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hemoglobin
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hemoglobin
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.195
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Aorta
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0114
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Syndactylism
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Syndactylism
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Teeth presence
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Teeth presence
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Optic Disc
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Optic Disc
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - back
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - back
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Narrow eye opening
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
5.73×10-07
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Narrow eye opening
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Heart weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Heart weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.458
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - back
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - back
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.0582
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.000260
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Shape
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Blood glucose concentration
|
HOM
|
f:10m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Blood glucose concentration
|
HET
|
40f:40m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00441
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Fertility of Homozygous Knock-out Mice / Gross Findings Male
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / NKT Effector
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Neutrophils
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Stroke Volume
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Stroke Volume
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.0654
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Comment on XRay image
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Comment on XRay image
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte differential count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.691
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / NKT Resting
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean/Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean/Body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0556
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled - total
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled - total
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0101
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Snout size
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
4.90×10-05
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Snout size
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Synechia
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Synechia
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / Click-evoked ABR threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0462
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / Click-evoked ABR threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.253
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 24kHz-evoked ABR Threshold
|
HET
|
2f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
0.0256
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Auditory Brain Stem Response / 24kHz-evoked ABR Threshold
|
HOM
|
f:2m
|
Reference Range Plus Test framework; quantile = 0.95 (Tails probability = 0.025)
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total cholesterol
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total cholesterol
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0114
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Albumin
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Albumin
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.933
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.334
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HR
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HR
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.406
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Pelvis
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
8.14×10-05
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Pelvis
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / B1 Total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lung
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid morphology
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.00152
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid morphology
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - shape
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - shape
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell volume
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell volume
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.154
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Spleen
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - back
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - back
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.311
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement
|
HOM
|
f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement
|
HET
|
24f:24m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena permanence
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena permanence
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / Eosinophils
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper lip morphology
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper lip morphology
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Locomotor activity
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Locomotor activity
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.128
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lower Urinary Tract
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Ovary
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HRV
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HRV
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00143
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.877
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Uterus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Mandibles
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Mandibles
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - back paws
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - back paws
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - whole body
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - whole body
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of digits
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of digits
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - abdomen
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - abdomen
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / NKT Total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brainstem
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - shape
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - head
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - head
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Oral epithelium
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Fructosamine
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Fructosamine
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.000732
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alkaline phosphatase
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alkaline phosphatase
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.502
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye Hemorrhage or Blood Presence
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye Hemorrhage or Blood Presence
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte cell count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte cell count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.719
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Teeth
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
3.33×10-06
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Teeth
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Systolic Diameter
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Systolic Diameter
|
HET
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.659
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / White Adipose Tissue
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight
|
HET
|
98f:99m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight
|
HOM
|
f:26m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / B cell total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Fusion between cornea and lens
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Fusion between cornea and lens
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - head
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - head
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean corpuscular hemoglobin
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean corpuscular hemoglobin
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.000873
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - shape
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - shape
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - size
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - size
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) differential count
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) differential count
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0792
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0556
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total bilirubin
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total bilirubin
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.724
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / CV
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / CV
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00769
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of ribs
|
HET
|
6f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of ribs
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / BMC/Body weight
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / BMC/Body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00513
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower lip morphology
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower lip morphology
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brown adipose tissue
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.594
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Structure
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Structure
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Joints
|
HET
|
6f:6m
|
Fisher Exact Test framework
|
0.0132
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Joints
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Large Intestine
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HET
|
24f:24m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HOM
|
f:6m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Gait
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
0.0172
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Gait
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell distribution width
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell distribution width
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00433
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Ears
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Ears
|
HOM
|
f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
FACS / CD8 T cells total
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed series
|
HOM
|
f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed series
|
HET
|
32f:32m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brain
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia length
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia length
|
HET
|
6f:4m
|
Linear Mixed Model framework, LME, including Weight
|
0.986
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4_S
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0101
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - tail
|
HET
|
8f:8m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - tail
|
HOM
|
f:2m
|
|
|
NotProcessed |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HET
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt1tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |