Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - thickness
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - thickness
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw footpad size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - back
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - back
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Bulging eye
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Bulging eye
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Bulging eye
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Bone marrow - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / External genitalia morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris/Pupil
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris/Pupil
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Iris/Pupil
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cartilage tissue
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Snout morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.197
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell hemoglobin concentration
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell hemoglobin concentration
|
HOM
|
8f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.349
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Mean cell hemoglobin concentration
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.907
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Striatum
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Kyphosis
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Body weight before experiment
|
HOM
|
f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Body weight before experiment
|
HET
|
f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Body weight before experiment
|
HOM
|
f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Lumbar processes
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Incisors morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.0334
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Heart Weight / Heart weight normalised against body weight
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Urinary bladder - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Total food intake
|
HOM
|
f:5m
|
Linear Mixed Model framework, LME, including Weight
|
0.901
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fibula
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fibula
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Fibula
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / 6kHz-evoked ABR Threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of vertebrae
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Shape of vertebrae
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.450
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of vertebrae
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Body length
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.269
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Cortical Bone MicroCT / Cortical Bone Mineral Density
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Peyers Patch
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Small Intestine
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thyroid
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Spinal cord - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Stomach - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens Opacity
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Lens Opacity
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.410
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens Opacity
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - back paws
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - back paws
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Antigen Specific Immunoglobulin Assay / Comment
|
HOM
|
f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb skin appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / LDL-cholesterol
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0464
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - shape
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Vertebral Microradiography / Vertebral Height
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0228
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindlimb size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / CD8+CD44+CD62L- percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lymph Node
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Zygomatic bone
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Zygomatic bone
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Zygomatic bone
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head skin colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Calcium
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Calcium
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.189
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Calcium
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.415
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / HR
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / HR
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.833
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral coat/hair colour pattern
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of ribs
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Shape of ribs
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Shape of ribs
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center movement time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center movement time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.827
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Spleen - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - ear
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - ear
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Number of signals
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Number of signals
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - number
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - number
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.112
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.168
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Body weight
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Body weight
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.284
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.950
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail length
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Potassium
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Potassium
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.000368
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Potassium
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.168
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.968
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / 30kHz-evoked ABR Threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Seminal vesicle - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Phosphorus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Phosphorus
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.509
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Phosphorus
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.550
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - shape
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - morphology
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Viability Primary Screen / Viability Outcome
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Viability Primary Screen / Viability Outcome
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.397
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lymph node
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Spleen Dilution Reading
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head bobbing/circling
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.00969
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head morphology
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw nail colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / ST
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / ST
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.141
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Respiratory Exchange Ratio
|
HET
|
f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Respiratory Exchange Ratio
|
HOM
|
f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.600
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Respiratory Exchange Ratio
|
HOM
|
f:5m
|
Linear Mixed Model framework, LME, including Weight
|
0.939
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Digit coat/hair colour pattern
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal vascularization
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal vascularization
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Corneal vascularization
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Pattern
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Pattern
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retinal Blood Vessels Pattern
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Triglycerides
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Triglycerides
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.143
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Triglycerides
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.349
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Platelet count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Platelet count
|
HOM
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.847
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Platelet count
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.906
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / External genitalia
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindlimb morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Cumulative food intake
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Thymus
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Thymus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Skeletal Muscle
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery distance travelled series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Position
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Position
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Pupil Position
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - position
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - position
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb skin colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Peripheral Nervous System
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.0152
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Latency to center entry
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Latency to center entry
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.464
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Scoliosis
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Incisor colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Mammary gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.567
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of vertebrae
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of vertebrae
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
7.84×10-07
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Fusion of vertebrae
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.606
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Esophagus - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Mammary gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - morphology
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Tibia
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Trachea - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - abdomen
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - abdomen
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head skin appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0972
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.172
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw footpad skin appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Caecal Contents Dilution Reading
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Digit coat/hair appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Adrenal gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Lens
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.410
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Lens
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QTc
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QTc
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0897
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.973
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head size
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.141
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Sodium
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Sodium
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Sodium
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.00731
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - shape
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Femoral Microradiography / Femur Length
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / T cell CD3+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Alive
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Alive
|
HOM
|
2f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Alive
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral coat/hair colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull)
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.775
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull)
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.954
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Corneal touch reflex
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0576
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Contact righting reflex
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - snout
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - snout
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skin
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw nail morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Trachea
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / Comment
|
HOM
|
f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / HDL-cholesterol
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / HDL-cholesterol
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.269
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / HDL-cholesterol
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.515
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Persistence of hyaloid vascular system
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Persistence of hyaloid vascular system
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
0.0883
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Persistence of hyaloid vascular system
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.430
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cerebral Cortex
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Processes on vertebrae
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Processes on vertebrae
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
0.00100
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Vertebra Compression / Vertebra Yield Load
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Maxilla/Pre-maxilla
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Maxilla/Pre-maxilla
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.120
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Maxilla/Pre-maxilla
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Lymphocyte differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.103
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Brown adipose tissue - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Body weight
|
HOM
|
3f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength measurement
|
HOM
|
9f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Mouth morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Mouth morphology
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HOM
|
9f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hot Plate / Time of first response
|
HOM
|
3f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hot Plate / Type of response
|
HOM
|
3f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Testis
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.212
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Gait (inc. ataxia)
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail coat/hair appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Kidney
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hot Plate / Body Weight
|
HOM
|
3f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Caudal processes
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral skin appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindlimb
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head bobbing
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Head bobbing
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Pituitary gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal coat/hair colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Prostate - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of ribs right
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs right
|
HOM
|
6f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs right
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / rMSSD
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / rMSSD
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.646
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina
|
HOM
|
8f:8m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retina
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - ear
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - ear
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Body weight
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Body weight
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alpha-amylase
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alpha-amylase
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.0143
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Alpha-amylase
|
HOM
|
7f:6m
|
Linear Mixed Model framework, LME, including Weight
|
0.864
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center average speed series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PR
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PR
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.153
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Iron
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Iron
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.128
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Iron
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.323
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Magnesium
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.126
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Convulsions
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery permanence time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.297
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - length
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - length
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Sternum - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWd
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWd
|
HOM
|
8f:m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.323
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw digit size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Pre-Day 14 Death
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Aggression
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Aggression
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw digit fusion
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Number of center entries
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Number of center entries
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, including Weight
|
0.433
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement mean
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength measurement mean
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0666
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement mean
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.823
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - shape
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Startle response
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Startle response
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Olfactory Lobe
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral coat/hair appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Three-point Bend / Energy Dissipated Prior to Fracture
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - BN
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - BN
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWs
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWs
|
HOM
|
8f:m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.197
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb coat/hair appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Gall bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Femur
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Femur
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Femur
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Heart - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Cornea
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Cornea
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Cornea
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Free fatty acids
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.000981
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Adrenal gland - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / 12kHz-evoked ABR Threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Tibia - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.671
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull)
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.413
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull)
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.440
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Ejection Fraction
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Ejection Fraction
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.249
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna position
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Red blood cell count
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.101
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell count
|
HOM
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.666
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw coat/hair colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Knee joint - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / LIH (Hemolysis Severity - available on AU analysers)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / LIH (Hemolysis Severity - available on AU analysers)
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw digit count
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - tail
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - tail
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / Mature B cell IgD+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris Pigmentation
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Iris Pigmentation
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Iris Pigmentation
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - appearance
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - appearance
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw footpad skin colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / T cell CD4+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Liver Weight
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Right kidney
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Right kidney
|
HOM
|
7f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.677
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Neutrophil cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.776
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Startle response
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Seminal vesicle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Thoracic processes
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.169
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Humerus
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Humerus
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Humerus
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Large intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Limb grasp
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Limb grasp
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Femur - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Cerebellum
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - head
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - head
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN)
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.521
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN)
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.986
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean R amplitude
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean R amplitude
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - presence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Genitalia - presence
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery resting time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0892
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of lumbar vertebrae
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Lordosis
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral skin colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Ulna
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Ulna
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Ulna
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Sacral processes
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Uterus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Spleen weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Spleen weight
|
HOM
|
7f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.342
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - number
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - number
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw digit count
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - length
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - length
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Stomach
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Body weight after experiment
|
HOM
|
f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Body weight after experiment
|
HET
|
f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Body weight after experiment
|
HOM
|
f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Digit coat/hair presence
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / External genitalia size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of caudal vertebrae
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Liver Counts in 20 micro litres
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Unexpected behaviors
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Unexpected behaviors
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.852
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of ribs left
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs left
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of ribs left
|
HOM
|
6f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Large intestine - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw nail colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimbs - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - front paws
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - front paws
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Area
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Bone Area
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.134
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Bone Area
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.627
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Mammary gland - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Vascular System
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QT
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QT
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.191
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Cardiac Output
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Cardiac Output
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.509
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDs
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDs
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.134
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retinal Pigmentation
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Pigmentation
|
HOM
|
8f:8m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Pigmentation
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Liver
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Gall Bladder
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Stomach
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Heart
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - position
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimbs - position
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw digit morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Small intestine - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Comment
|
HOM
|
f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail skin colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3_S
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3_S
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw digit size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - front paws
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - front paws
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Basophil differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.635
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Trachea
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - abdomen
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - abdomen
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Glucose
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Glucose
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.667
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Glucose
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.671
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2_S
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2_S
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Hippocampus
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Epididymis - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Fertility of Homozygous Knock-out Mice / Gross Findings Female
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Fertility of Homozygous Knock-out Mice / Gross Findings Female
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Skull shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Skull shape
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.0424
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Skull shape
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Fractional Shortening
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Fractional Shortening
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.257
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - number
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - number
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Salivary gland - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Oxygen consumption
|
HOM
|
f:669m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Oxygen consumption
|
HET
|
f:61m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Oxygen consumption
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QRS
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / QRS
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.279
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Spinal cord
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forelimb
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Small intestine
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - number
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - number
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Digit coat/hair colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - presence
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tail - presence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Trigeminal V nerve - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Chloride
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Chloride
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Chloride
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.388
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Insulin Blood Level / Insulin
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.00563
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Thymus - MPATH diagnostic term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.818
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean mass
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Lean mass
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.154
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean mass
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.295
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Light Response
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Light Response
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Pupil Light Response
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal opacity
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Corneal opacity
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Corneal opacity
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / Treg cell CD25+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Prostate gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.212
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of pelvic vertebrae
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Shape of ribcage
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.0283
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Ovary
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tremor
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Left kidney
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Left kidney
|
HOM
|
7f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.367
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / White blood cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / White blood cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.0483
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / White blood cell count
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.444
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alanine aminotransferase
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alanine aminotransferase
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
6.48×10-06
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Alanine aminotransferase
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.790
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Ophthalmoscope Observation
|
HOM
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Ophthalmoscope Observation
|
HOM
|
2f:2m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWd
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVPWd
|
HOM
|
8f:m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.440
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb nail - shape
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / RR
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / RR
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.420
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - whole body
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - whole body
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatinine
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Creatinine
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.542
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatinine
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.998
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal coat/hair appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of thoracic vertebrae
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb coat/hair colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Trabecular Bone MicroCT / Trabecular Thickness (mm)
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Brain - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Radius
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Radius
|
HOM
|
6f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Radius
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Uterus - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail coat/hair colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Percentage center time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.219
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean platelet volume
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean platelet volume
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0228
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Mean platelet volume
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.436
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.356
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWs
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVAWs
|
HOM
|
8f:m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.0689
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Brachydactyly
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Brachydactyly
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Brachydactyly
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - presence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vibrissae - presence
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail skin appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower teeth appearance
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower teeth appearance
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw nail morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Scapulae
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Scapulae
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Scapulae
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / Monocyte percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw digit fusion
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Parathyroid gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retinal Structure
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Structure
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Structure
|
HOM
|
8f:8m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Skin
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Esophagus
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina (combined)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retina (combined)
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.266
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retina (combined)
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Body weight
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Heart Weight / Body weight
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spleen
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Pancreas
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Polysyndactylism
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Epididymis
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Contact righting
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Contact righting
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hematocrit
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Hematocrit
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.299
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hematocrit
|
HOM
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.918
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Antigen Specific Immunoglobulin Assay / TetC specific total IgG
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Esophagus
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - head
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - head
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Vibrissae shape
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatine kinase
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Creatine kinase
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
1.49×10-07
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Creatine kinase
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.00239
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - abdomen
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - abdomen
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1_S
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1_S
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Hypothalamus
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Dilation
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Dilation
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Pupil Dilation
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat mass
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Fat mass
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.369
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat mass
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.710
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Three-point Bend / Stiffness
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw coat/hair appearance
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Liver Dilution Reading
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tremor
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Tremor
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Thyroxine
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.579
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Diastolic Diameter
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Diastolic Diameter
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.344
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Brain
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forelimb size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Total water intake
|
HOM
|
f:5m
|
Linear Mixed Model framework, LME, not including Weight
|
0.556
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal skin colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper teeth appearance
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper teeth appearance
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Carbon dioxide production
|
HOM
|
f:669m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Carbon dioxide production
|
HET
|
f:61m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Carbon dioxide production
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, including Weight
|
0.684
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / T cell CD8+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Intraperitoneal glucose tolerance test (IPGTT) / Body Weight
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Body Weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Body Weight
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / 18kHz-evoked ABR Threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Eye
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean SR amplitude
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / Mean SR amplitude
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Thyroid gland
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Clavicle
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Clavicle
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Clavicle
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight curve
|
HET
|
15f:13m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight curve
|
HOM
|
124f:152m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Weight / Body weight curve
|
HOM
|
92f:123m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Weight / Body weight curve
|
HOM
|
15f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PQ
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / PQ
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.203
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / Body weight
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Activity (body position)
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Activity (body position)
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Liver
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Trabecular Bone MicroCT / Trabecular Spacing (mm)
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Heart
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / NK cell percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - size
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail coat/hair colour pattern
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Digit integrity
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Digit integrity
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
0.285
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Digit integrity
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw nail length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Slit Lamp observation
|
HOM
|
f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - snout
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin texture - snout
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total protein
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Total protein
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.842
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total protein
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.905
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Respiration Rate
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Respiration Rate
|
HOM
|
7f:m
|
Linear Mixed Model framework, LME, not including Weight
|
0.372
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat/Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Fat/Body weight
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0845
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Fat/Body weight
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.420
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal coat/hair colour pattern
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of cervical vertebrae
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Thyroid - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid closure
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid closure
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Eyelid closure
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head coat/hair colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Three-point Bend / Fracture Load
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Days post-infection
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / Granulocyte Gr1+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Oviduct
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.0584
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb coat/hair colour pattern
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDd
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / LVIDd
|
HOM
|
8f:m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.119
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - length
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - length
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Aspartate aminotransferase
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Aspartate aminotransferase
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.000127
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Aspartate aminotransferase
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.00908
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Bone
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw digit morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Eosinophil cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.108
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vocalization
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Vocalization
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
0.169
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hemoglobin
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Hemoglobin
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.176
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Hemoglobin
|
HOM
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.545
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Aorta
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.0152
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Heat production (metabolic rate)
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Heat production (metabolic rate)
|
HET
|
f:61m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Heat production (metabolic rate)
|
HOM
|
f:669m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Syndactylism
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Syndactylism
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Syndactylism
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0268
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Teeth presence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Teeth presence
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forelimb morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Optic Disc
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Optic Disc
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Optic Disc
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - back
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color pattern - back
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Narrow eye opening
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Narrow eye opening
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Narrow eye opening
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Skin - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Lung - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Glycerol
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.345
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Weight / Body Weight
|
HOM
|
9f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Heart weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Heart Weight / Heart weight
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.575
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Organ Weight / Heart weight
|
HOM
|
7f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.782
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Vibrissae size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal skin appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Prostate
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Vibrissae colour
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - back
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - back
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Lung
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw footpad size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Pupil Shape
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Pupil Shape
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.333
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0348
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Blood glucose concentration
|
HET
|
5f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Blood glucose concentration
|
HOM
|
40f:45m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Intraperitoneal glucose tolerance test (IPGTT) / Blood glucose concentration
|
HOM
|
35f:35m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Fertility of Homozygous Knock-out Mice / Gross Findings Male
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Fertility of Homozygous Knock-out Mice / Gross Findings Male
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Cervical processes
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.539
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Pancreas
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Stroke Volume
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / Stroke Volume
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.409
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw coat/hair colour pattern
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Comment on XRay image
|
HOM
|
6f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Comment on XRay image
|
HOM
|
2f:2m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Three-point Bend / Yield Load
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.0720
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw nail count
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Cortical Bone MicroCT / Cortical Thickness
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Spinal cord
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean/Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / Lean/Body weight
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00472
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / Lean/Body weight
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0975
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Thymus - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / NKT cell percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Kidney - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Snout size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Snout size
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled - total
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Distance travelled - total
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0305
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Lymph node - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / Click-evoked ABR threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Synechia
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Synechia
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Synechia
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Auditory Brain Stem Response / 24kHz-evoked ABR Threshold
|
HOM
|
1f:5m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total cholesterol
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Total cholesterol
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0591
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total cholesterol
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.263
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Albumin
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Albumin
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.518
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Albumin
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.758
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Pancreas - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HR
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HR
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.331
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.357
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.759
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Antigen Specific Immunoglobulin Assay / TetC specific IgG1
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Testes - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Transitional vertebrae
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Pelvis
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Pelvis
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.308
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Pelvis
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Adrenal gland
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lung
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00433
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna rotation
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Urinary bladder
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eyelid morphology
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Eyelid morphology
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Shape of spine
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - shape
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forelimb digit - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Mean cell volume
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell volume
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean cell volume
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.960
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Spleen
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - back
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - back
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Femoral Microradiography / Femoral Bone Mineral Content
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Vertebra Compression / Vertebra Max Load
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center permanence time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.219
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Ovary - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement
|
HOM
|
24f:27m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb grip strength measurement
|
HET
|
3f:3m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength measurement
|
HOM
|
21f:21m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindpaw - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena permanence
|
HOM
|
8f:10m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena permanence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper lip morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Upper lip morphology
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Locomotor activity
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Locomotor activity
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.393
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / B cell CD19+ percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna skin colour
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Spleen Weight
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Positional passivity
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw nail length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Lower Urinary Tract
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.0844
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Skeletal muscle
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head coat/hair colour pattern
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Ambulatory activity (no. of beam cuts)
|
HET
|
f:61m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Ambulatory activity (no. of beam cuts)
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Ambulatory activity (no. of beam cuts)
|
HOM
|
f:669m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Digit coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Ovary
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HRV
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / HRV
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.149
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retinal Blood Vessels
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.693
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Trabecular Bone MicroCT / Trabecular Number (mm-1)
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Uterus
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.247
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Skeletal muscle - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Mandibles
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Mandibles
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Mandibles
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Vibrissae
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna touch reflex
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Ventral coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - back paws
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - back paws
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Caecal Contents Counts in 20 micro litres
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Mouth morphology
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - whole body
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - whole body
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - abdomen
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - abdomen
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of digits
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Number of digits
|
HOM
|
6f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Number of digits
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center distance travelled series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dysmorphology comment
|
HOM
|
f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena resting time series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Gall bladder - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Incisors
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brainstem
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb nail - shape
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - head
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - hair distribution - head
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Hindpaw size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Oral epithelium
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Vertebral Microradiography / Vertebral Bone Mineral Content
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Fructosamine
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Fructosamine
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.402
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Fructosamine
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.577
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alkaline phosphatase
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Alkaline phosphatase
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.807
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Alkaline phosphatase
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.898
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye Hemorrhage or Blood Presence
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Eye Hemorrhage or Blood Presence
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Eye Hemorrhage or Blood Presence
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte cell count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Monocyte cell count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.273
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Teeth
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Teeth
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
0.0247
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Teeth
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Systolic Diameter
|
HET
|
1f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Echo / End-Systolic Diameter
|
HOM
|
8f:m
|
Linear Mixed Model framework, LME, including Weight
|
0.115
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Paw coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Cortical Bone MicroCT / Internal Diameter
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Liver - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Buffy coat peripheral blood leukocyte immunophenotyping / CD4+CD44+CD62L- percentage
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / White Adipose Tissue
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.455
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight
|
HOM
|
98f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Weight / Body weight
|
HET
|
12f:8m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Weight / Body weight
|
HOM
|
70f:83m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Antigen Specific Immunoglobulin Assay / TetC specific IgG2
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Fusion between cornea and lens
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Fusion between cornea and lens
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Fusion between cornea and lens
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - head
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Coat - color - head
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean corpuscular hemoglobin
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Mean corpuscular hemoglobin
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.169
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Mean corpuscular hemoglobin
|
HOM
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.333
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail coat/hair presence
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw size
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - shape
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Hindlimb digit - shape
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - size
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Forepaw - size
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) differential count
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Large Unstained Cell (LUC) differential count
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.0482
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.506
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.975
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total bilirubin
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Clinical Chemistry / Total bilirubin
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.268
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Clinical Chemistry / Total bilirubin
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.719
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / CV
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Electrocardiogram (ECG) / CV
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.306
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Indirect Calorimetry / Total activity (no. of fine movement + no. of beam cuts)
|
HOM
|
f:106m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Total activity (no. of fine movement + no. of beam cuts)
|
HOM
|
f:669m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Indirect Calorimetry / Total activity (no. of fine movement + no. of beam cuts)
|
HET
|
f:61m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Histopathology / Eye with optic nerve - MPATH process term
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of ribs
|
HOM
|
6f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Fusion of ribs
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Fusion of ribs
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb grasping
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / BMC/Body weight
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Body Composition (DEXA lean/fat) / BMC/Body weight
|
HOM
|
6f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0268
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Body Composition (DEXA lean/fat) / BMC/Body weight
|
HOM
|
8f:9m
|
Linear Mixed Model framework, LME, not including Weight
|
0.730
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower lip morphology
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Lower lip morphology
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Salmonella Challenge / Spleen Counts in 20 micro litres
|
HOM
|
f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brown adipose tissue
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Testes
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head coat/hair appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Forepaw nail count
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Center resting time
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0167
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Vertebra Compression / Vertebra Stiffness
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Structure
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Eye Morphology / Retinal Blood Vessels Structure
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Eye Morphology / Retinal Blood Vessels Structure
|
HOM
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Joints
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Joints
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Joints
|
HOM
|
6f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HOM
|
24f:27m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HET
|
3f:3m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HOM
|
21f:21m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Large Intestine
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.106
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna skin appearance
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Gait
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Gait
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
8.49×10-07
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Kidney
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
X-ray / Fusion of processes
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell distribution width
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Hematology / Red blood cell distribution width
|
HOM
|
7f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.597
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Hematology / Red blood cell distribution width
|
HOM
|
8f:9m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.606
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Ears
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Ears
|
HOM
|
8f:9m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed series
|
HET
|
4f:4m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Periphery average speed series
|
HOM
|
32f:40m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Adult LacZ / Brain
|
HET
|
4f:2m
|
Fisher Exact Test framework
|
0.00216
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Snout size
|
HOM
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia length
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
X-ray / Tibia length
|
HOM
|
6f:9m
|
Linear Mixed Model framework, LME, including Weight
|
0.00683
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Open Field / Whole arena average speed
|
HOM
|
8f:10m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0305
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4_S
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4_S
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Three-point Bend / Max Load
|
HOM
|
2f:m
|
|
|
NotProcessed |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Dorsal coat/hair length
|
HOM
|
7f:7m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - tail
|
HET
|
1f:1m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Combined SHIRPA and Dysmorphology / Skin color - tail
|
HOM
|
8f:9m
|
|
|
NotProcessed |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1b(EUCOMM)Wtsi
|
MRC Harwell
|
Gross Pathology and Tissue Collection / Eye with optic nerve
|
HOM
|
f:m
|
Supplied as data
|
1.00
|
Successful |
Sirt3tm1a(EUCOMM)Wtsi
|
WTSI
|
Trabecular Bone MicroCT / Bone Volume/Tissue Volume (%)
|
HOM
|
2f:m
|
|
|
NotProcessed |