Orc1tm1b(KOMP)Wtsi
|
JAX
|
Electroconvulsive Threshold Testing / mA threshold inducing clonic seizure
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.296
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Whole arena average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.593
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Gait (inc. ataxia)
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Hole-board Exploration / Holepoke sequence
|
HET
|
232f:257m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Activity (body position)
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Head bobbing
|
HET
|
8f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Percent time in light
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00600
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Center average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.442
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Center permanence time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.863
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Side changes
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.000221
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E12.5 / Midbrain morphology
|
HET
|
6f:5m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Indirect Calorimetry / Cumulative food intake
|
HET
|
f:155m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Hole-board Exploration / Total holepokes
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.372
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
0.209
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Unexpected behaviors
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Convulsions
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0375
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Light side time spent
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0103
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E12.5 / Neural Tube Closure
|
HET
|
6f:5m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Periphery distance travelled
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.534
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E12.5 / Forebrain morphology
|
HET
|
6f:5m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Indirect Calorimetry / Total food intake
|
HET
|
f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0154
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Whole arena resting time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.736
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Trunk curl
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Aggression
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Number of Rears
|
HET
|
32f:32m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Time mobile light side
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0135
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength measurement mean
|
HET
|
9f:7m
|
Linear Mixed Model framework, LME, including Weight
|
2.53×10-05
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb grip strength measurement mean
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0349
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Startle response
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Percentage center time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.863
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E9.5 / Midbrain
|
HET
|
12f:9m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Distance travelled
|
HET
|
32f:32m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - BN
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Indirect Calorimetry / Total activity (no. of fine movement + no. of beam cuts)
|
HET
|
f:155m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E12.5 / Hindbrain morphology
|
HET
|
6f:5m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Limb grasping
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Vocalization
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Touch escape
|
HET
|
8f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Tail Suspension / Time immobile
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.564
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Dark side time spent
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0103
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HET
|
9f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.0377
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb and hindlimb grip strength measurement mean
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.219
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Number of rears - total
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.0495
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength measurement
|
HET
|
27f:21m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb grip strength measurement
|
HET
|
24f:24m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Rotarod / Latency to fall
|
HET
|
40f:40m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Tail Suspension / Latency to immobility
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.482
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E9.5 / Neural tube closure
|
HET
|
12f:9m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HET
|
9f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.000474
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb grip strength normalised against body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0101
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Locomotor activity
|
HET
|
8f:7m
|
Linear Mixed Model framework, LME, including Weight
|
0.122
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Eye Morphology / Optic Disc
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Eye Morphology / Optic Disc
|
HET
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HET
|
8f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP2_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Periphery average speed
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.557
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Time mobile dark side
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.616
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Fecal boli
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.690
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Contact righting
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.105
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight
|
HET
|
9f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.172
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HET
|
24f:24m
|
|
|
NotProcessed |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Grip Strength / Forelimb and hindlimb grip strength measurement
|
HET
|
27f:21m
|
|
|
NotProcessed |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Positional passivity
|
HET
|
9f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Distance travelled - total
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.591
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Indirect Calorimetry / Ambulatory activity (no. of beam cuts)
|
HET
|
f:155m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Gross Morphology Embryo E9.5 / Forebrain
|
HET
|
12f:9m
|
Supplied as data
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Corneal touch reflex
|
HET
|
9f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP1_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Periphery permanence time
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.863
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Gait
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Rotarod / Learning slope
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.00881
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0320
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Contact righting reflex
|
HET
|
9f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.0383
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Startle response
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Tremor
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.126
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Pinna touch reflex
|
HET
|
9f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00196
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Latency to first transition into dark
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.575
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Rotarod / Learning difference
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, not including Weight
|
0.130
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4
|
HET
|
8f:8m
|
Linear Model Using Generalized Least Squares framework, GLS, including Weight
|
0.155
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Indirect Calorimetry / Total water intake
|
HET
|
f:7m
|
Linear Mixed Model framework, LME, not including Weight
|
0.718
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP3
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Limb grasp
|
HET
|
8f:7m
|
Fisher Exact Test framework
|
0.388
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Eye Morphology / Pupil Light Response
|
HET
|
8f:8m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Eye Morphology / Pupil Light Response
|
HET
|
7f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Head bobbing/circling
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - PP4_S
|
HET
|
8f:8m
|
|
|
NotProcessed |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tail elevation
|
HET
|
9f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Combined SHIRPA and Dysmorphology / Transfer arousal
|
HET
|
8f:7m
|
|
|
NotProcessed |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Light-Dark Test / Percent time in dark
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.00600
|
Successful |
Orc1tm1a(KOMP)Wtsi
|
WTSI
|
Combined SHIRPA and Dysmorphology / Tremor
|
HET
|
9f:7m
|
Fisher Exact Test framework
|
1.00
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Rotarod / Average duration
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, including Weight
|
0.891
|
Successful |
Orc1tm1b(KOMP)Wtsi
|
JAX
|
Open Field - centre start / Center distance travelled
|
HET
|
8f:8m
|
Linear Mixed Model framework, LME, not including Weight
|
0.855
|
Successful |