All behavior/neurological phenotype, nervous system phenotype data for Knstrn

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status Graph
Knstrntm1b(KOMP)Wtsi ICS Open Field / Periphery resting time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.77832 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Center permanence time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.31552 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Whole arena resting time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.95436 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Activity (body position) HOM 12f:8m Fisher Exact Test framework 0.67428 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Head bobbing HOM 12f:8m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Knstrntm1b(KOMP)Wtsi ICS Grip Strength / Forelimb grip strength normalised against body weight HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.42766 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Trunk curl HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Center resting time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.16197 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Locomotor activity HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.70487 Success
Knstrntm1b(KOMP)Wtsi ICS Eye Morphology / Optic Disc HOM 11f:7m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Center average speed HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.11805 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Contact righting HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Grip Strength / Forelimb and hindlimb grip strength normalised against body weight HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.11935 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Distance travelled - total HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.44180 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Number of rears - total HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.24364 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Unexpected behaviors HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.82891 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_037_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Open Field / Periphery permanence time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.31546 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Gait HOM 12f:8m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.95561 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_033_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.50937 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_035_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Rotarod / Latency to fall mean HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.25667 Success
Knstrntm1b(KOMP)Wtsi ICS Indirect Calorimetry / Total food intake HOM 3f:2m Not processed 1.0000 FAILED - Not enough mutant or control data
Knstrntm1b(KOMP)Wtsi ICS Open Field / Latency to center entry HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.48772 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Percentage center time HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.31551 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Aggression HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Number of center entries HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.32522 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Tremor HOM 12f:8m Fisher Exact Test framework 1.8695E-05 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.54853 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_034_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.97960 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Grip Strength / Forelimb grip strength measurement mean HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.29822 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Startle response HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Periphery average speed HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.12527 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4 HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.77657 Success
Knstrntm1b(KOMP)Wtsi ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4 HOM 5f:2m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_ACS_036_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Knstrntm1b(KOMP)Wtsi ICS Indirect Calorimetry / Total water intake HOM 3f:2m Not processed 1.0000 FAILED - Not enough mutant or control data
Knstrntm1b(KOMP)Wtsi ICS Eye Morphology / Pupil Light Response HOM 4f:1m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Limb grasp HOM 12f:8m Fisher Exact Test framework 1.0000 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Whole arena average speed HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.13868 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Center distance travelled HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.68581 Success
Knstrntm1b(KOMP)Wtsi ICS Combined SHIRPA and Dysmorphology / Vocalization HOM 12f:8m Fisher Exact Test framework 0.49861 Success
Knstrntm1b(KOMP)Wtsi ICS Open Field / Periphery distance travelled HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.24986 Success
Knstrntm1b(KOMP)Wtsi ICS Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 12f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.14244 Success

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