Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  thickness 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Alanine aminotransferase 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.63929

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Alanine aminotransferase 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_013_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  back 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVPWd 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.25932

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVPWd 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Bulging eye 
HOM 
11f:7m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / RR 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.16505

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / RR 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_004_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  whole body 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left vitreous humour thickness 
HOM 
11f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.10043

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Trunk curl 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Creatinine 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.20846

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Creatinine 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_005_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Iris/Pupil 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of thoracic vertebrae 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_014_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Mean cell hemoglobin concentration 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.046185

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Radius 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal deposits 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Indirect Calorimetry / Total food intake 
HOM 
3f:2m 
Not processed 
1.0000

FAILED  Not enough mutant or control data 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Fibula 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Percentage center time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.31551

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Eosinophil differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_035_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Auditory Brain Stem Response / 6kHzevoked ABR Threshold 
HOM 
8f:5m 

1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Shape of vertebrae 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Body length 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.33381

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Body length 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Brachydactyly 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vibrissae  presence 
HOM 
12f:8m 
Fisher Exact Test framework 
0.62407

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Lower teeth appearance 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Scapulae 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Lens Opacity 
HOM 
3f:1m 
 
1.0000

FAILED  Not enough mutant measurements (3f/1m) 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  back paws 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  shape 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Periphery distance travelled 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.24986

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal mineralization 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Zygomatic bone 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Calcium 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.39315

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Calcium 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / HR 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.68133

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / HR 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_013_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Shape of ribs 
HOM 
10f:7m 
Fisher Exact Test framework 
0.39274

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Contact righting 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Hematocrit 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.00077665

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  ear 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  number 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.11935

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  number 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  head 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.57661

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  abdomen 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Pupil Dilation 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI3 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.50937

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI3 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_035_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat mass 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_002_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat mass 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_002_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Auditory Brain Stem Response / 30kHzevoked ABR Threshold 
HOM 
8f:5m 

1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left inner nuclear layer 
HOM 
11f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.0054658

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Phosphorus 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.013073

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Phosphorus 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_010_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tremor 
HOM 
12f:8m 
Fisher Exact Test framework 
1.8695E05

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Viability Primary Screen / Outcome 
HOM 
107f:97m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Large Unstained Cell (LUC) count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_039_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Indirect Calorimetry / Total water intake 
HOM 
3f:2m 
Not processed 
1.0000

FAILED  Not enough mutant or control data 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Lymphocyte cell count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_032_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / ST 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.48864

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / ST 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Indirect Calorimetry / Respiratory Exchange Ratio 
HOM 
3f:2m 
Not processed 
1.0000

FAILED  Not enough mutant or control data 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Upper teeth appearance 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Center distance travelled 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.68581

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Auditory Brain Stem Response / 18kHzevoked ABR Threshold 
HOM 
8f:5m 

1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal vascularization 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Retinal Blood Vessels Pattern 
HOM 
11f:7m 
Fisher Exact Test framework 
0.44826

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Triglycerides 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0065882

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Triglycerides 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_017_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right total retinal thickness 
HOM 
11f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.88911

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Clavicle 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Platelet count 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
6.3225E13

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Activity (body position) 
HOM 
12f:8m 
Fisher Exact Test framework 
0.67428

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Digit integrity 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  snout 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total protein 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.22857

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total protein 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Pupil Position 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  position 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat/Body weight 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat/Body weight 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of cervical vertebrae 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_013_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Latency to center entry 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.48772

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Eyelid closure 
HOM 
12f:8m 
Fisher Exact Test framework 
0.0073903

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVIDd 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.42840

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVIDd 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Fusion of vertebrae 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Tibia 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  abdomen 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Iris transilumination 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Aspartate aminotransferase 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.94687

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Aspartate aminotransferase 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_012_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  length 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  length 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Eosinophil cell count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_036_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vocalization 
HOM 
12f:8m 
Fisher Exact Test framework 
0.49861

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Grip Strength / Forelimb and hindlimb grip strength measurement mean 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.14244

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Hemoglobin 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.0062355

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Whole arena resting time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.95436

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Syndactylism 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Vitreous 
HOM 
11f:7m 
Fisher Exact Test framework 
0.55184

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Teeth presence 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Lens 
HOM 
3f:1m 
 
1.0000

FAILED  Not enough mutant measurements (3f/1m) 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / QTc 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.49339

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / QTc 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Grip Strength / Forelimb grip strength normalised against body weight 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.42766

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left corneal thickness 
HOM 
8f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.90221

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  back 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Optic Disc 
HOM 
11f:7m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Center average speed 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.11805

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Narrow eye opening 
HOM 
11f:7m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Heart Weight / Heart weight 
HOM 
11f:6m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.70246

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_005_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_005_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Neutrophil differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_029_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  snout 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  back 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / HDLcholesterol 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.91110

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / HDLcholesterol 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_016_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Persistence of hyaloid vascular system 
HOM 
11f:7m 
Fisher Exact Test framework 
0.66670

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI2 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.54853

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI2 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_034_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / Response amplitude  S 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.97960

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / Response amplitude  S 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Pupil Shape 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Periphery average speed 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.12527

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Fertility of Homozygous Knockout Mice / Gross Findings Male 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Eye 
HOM 
12f:8m 
Fisher Exact Test framework 
0.0094634

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Processes on vertebrae 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right vitreous humor thickness 
HOM 
11f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.045867

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Maxilla/Premaxilla 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Lymphocyte differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_031_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right anterior chamber depth 
HOM 
7f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.59803

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Mouth morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Monocyte differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_033_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head bobbing 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Heart Weight / Tibia length 
HOM 
10f:5m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.39784

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean/Body weight 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean/Body weight 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of ribs right 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_008_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  ear 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Distance travelled  total 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.44180

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Snout size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / PR 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.98541

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / PR 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Synechia 
HOM 
3f:1m 
 
1.0000

FAILED  Not enough mutant measurements (3f/1m) 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Auditory Brain Stem Response / 24kHzevoked ABR Threshold 
HOM 
8f:5m 

1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total cholesterol 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.53003

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total cholesterol 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_015_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Periphery permanence time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.31546

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right inner nuclear layer 
HOM 
11f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.00010731

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Albumin 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.22809

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Albumin 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  length 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  length 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / HR 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.19403

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / HR 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_002_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.26406

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVAWd 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.028931

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVAWd 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Aggression 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Number of center entries 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.32522

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Pelvis 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Grip Strength / Forelimb grip strength measurement mean 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.29822

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  shape 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Startle response 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Eyelid morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Mean cell volume 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
1.7659E49

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  back 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Femur 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Cornea 
HOM 
5f:1m 
Fisher Exact Test framework 
0.0026832

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left anterior chamber depth 
HOM 
8f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.022406

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Center permanence time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.31552

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Auditory Brain Stem Response / 12kHzevoked ABR Threshold 
HOM 
8f:5m 

1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  size 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  size 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Basophil cell count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Insufficient variability in dependent variable 'IMPC_HEM_037_001' for MM/TF framework. Fisher Exact Test can be better way to do the analysis. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_004_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_004_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Upper lip morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Red blood cell count 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
1.1501E15

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Locomotor activity 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.70487

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  tail 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Iris Pigmentation 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vibrissae  appearance 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Retinal Blood Vessels 
HOM 
11f:7m 
Fisher Exact Test framework 
0.41848

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI1 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.95561

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI1 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_033_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Lacrimation 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Mandibles 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right corneal thickness 
HOM 
7f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.97926

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Neutrophil cell count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_030_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Humerus 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  back paws 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Limb grasp 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  whole body 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of digits 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_028_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  abdomen 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Urea (Blood Urea Nitrogen  BUN) 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.17362

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Urea (Blood Urea Nitrogen  BUN) 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_004_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  head 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Periphery resting time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.77832

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  presence 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left outer nuclear layer 
HOM 
11f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.61722

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of lumbar vertebrae 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_015_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Ulna 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  head 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  number 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal Sclerization 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  number 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Alkaline phosphatase 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_014_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  length 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Eye Hemorrhage or Blood Presence 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Monocyte cell count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_034_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Number of rears  total 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.24364

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Unexpected behaviors 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Teeth 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  Global 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.82891

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  Global 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_037_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of ribs left 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_009_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  size 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Rotarod / Latency to fall mean 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.25667

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  front paws 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Area 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_010_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Area 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_010_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Fusion between cornea and lens 
HOM 
3f:1m 
 
1.0000

FAILED  Not enough mutant measurements (3f/1m) 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  head 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Mean corpuscular hemoglobin 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
5.7091E31

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVIDs 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.51884

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / LVIDs 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_011_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Right outer nuclear layer 
HOM 
11f:7m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.94412

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  shape 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  shape 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.046333

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Large Unstained Cell (LUC) differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_HEM_040_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  size 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total bilirubin 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.48221

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Total bilirubin 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  position 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  size 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Fusion of ribs 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / BMC/Body weight 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / BMC/Body weight 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Lower lip morphology 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / Basophil differential count 
HOM 
4f:2m 
Not processed 
1.0000

FAILED  Insufficient variability in dependent variable 'IMPC_HEM_038_001' for MM/TF framework. Fisher Exact Test can be better way to do the analysis. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  front paws 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  abdomen 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Center resting time 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.16197

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Glucose 
HOM 
6f:4m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.10837

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Clinical Chemistry / Glucose 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_CBC_018_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Retinal Blood Vessels Structure 
HOM 
11f:7m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Fertility of Homozygous Knockout Mice / Gross Findings Female 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Left total retinal thickness 
HOM 
11f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.045282

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Joints 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal ulcer 
HOM 
4f:1m 
Fisher Exact Test framework 
0.025480

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Skull shape 
HOM 
10f:7m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / Fractional Shortening 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.83303

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Echo / Fractional Shortening 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECH_005_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  number 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  number 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Gait 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / QRS 
HOM 
7f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.80722

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Electrocardiogram (ECG) / QRS 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ECG_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Ears 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  number 
HOM 
5f:2m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  presence 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI4 
HOM 
7f:6m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.77657

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI4 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_ACS_036_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Tibia length 
HOM 
10f:7m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
0.48857

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean mass 
HOM 
7f:3m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_003_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean mass 
HOM 
5f:2m 
Not processed 
1.0000

FAILED  Not enough data points in dependent variable 'IMPC_DXA_003_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Pupil Light Response 
HOM 
4f:1m 
Fisher Exact Test framework 
1.0000

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Eye Morphology / Corneal opacity 
HOM 
5f:1m 
Fisher Exact Test framework 
0.023042

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Open Field / Whole arena average speed 
HOM 
12f:8m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.13868

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Xray / Number of pelvic vertebrae 
HOM 
10f:7m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_016_001'. 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  number 
HOM 
7f:6m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Hematology / White blood cell count 
HOM 
9f:6m 
Mixed Model framework, linear mixedeffects model, equation withoutWeight 
0.045534

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  tail 
HOM 
12f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HOM 
f:m 
Supplied as data 

Success 

Knstrn^{tm1b(KOMP)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HOM 
f:m 
Supplied as data 

Success 
