All nervous system phenotype, behavior/neurological phenotype data for Aak1

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status Graph
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery resting time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.91562 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center permanence time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.067526 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Whole arena resting time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.94049 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Activity (body position) HOM 9f:9m Fisher Exact Test framework 0.71023 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Head bobbing HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Trunk curl HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Locomotor activity HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.18311 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center resting time HOM 9f:9m Mixed Model framework, generalized least squares, equation withWeight 0.29679 Success
Aak1tm1b(EUCOMM)Hmgu ICS Eye Morphology / Optic Disc HOM 8f:8m Fisher Exact Test framework 0.053852 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0019674 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Contact righting HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Distance travelled - total HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.012610 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Number of rears - total HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 2.4357E-14 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Unexpected behaviors HOM 9f:9m Fisher Exact Test framework 1.0000 Success
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.010200 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery permanence time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.067526 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Gait HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 9f:9m Mixed Model framework, generalized least squares, equation withoutWeight 4.8186E-06 Success
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.78155 Success
Aak1tm1b(EUCOMM)Hmgu ICS Rotarod / Latency to fall mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0010424 Success
Aak1tm1b(EUCOMM)Hmgu ICS Indirect Calorimetry / Total food intake HOM 6f:3m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_CAL_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Latency to center entry HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.30602 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Percentage center time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.067526 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Aggression HOM 9f:9m Fisher Exact Test framework 1.0000 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Number of center entries HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.23377 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Tremor HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00059233 Success
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 5.1680E-10 Success
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb grip strength measurement mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0030367 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Startle response HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 4.9400E-05 Success
Aak1tm1b(EUCOMM)Hmgu ICS Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4 HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.24930 Success
Aak1tm1b(EUCOMM)Hmgu ICS Indirect Calorimetry / Total water intake HOM 3f:3m Not processed 1.0000 FAILED - Not enough mutant measurements (3f/3m)
Aak1tm1b(EUCOMM)Hmgu ICS Eye Morphology / Pupil Light Response HOM 8f:8m Fisher Exact Test framework 0.12039 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Limb grasp HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Whole arena average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00016848 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center distance travelled HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.16788 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Vocalization HOM 9f:9m Fisher Exact Test framework 0.13938 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery distance travelled HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0022518 Success
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0016016 Success

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