All nervous system phenotype, behavior/neurological phenotype data for Aak1

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status Graph
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery resting time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.63734 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center permanence time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.11582 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Whole arena resting time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.61333 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Activity (body position) HOM 9f:9m Fisher Exact Test framework 1.0000 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Head bobbing HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb grip strength normalised against body weight HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.49123 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Trunk curl HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Locomotor activity HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.17565 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center resting time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.86694 Success
Aak1tm1b(EUCOMM)Hmgu ICS Eye Morphology / Optic Disc HOM 7f:8m Fisher Exact Test framework 0.081522 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0011332 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Contact righting HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb and hindlimb grip strength normalised against body weight HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.43113 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Distance travelled - total HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0048885 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Number of rears - total HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 5.1980E-15 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Unexpected behaviors HOM 9f:9m Fisher Exact Test framework 1.0000 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery permanence time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.11582 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Gait HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Rotarod / Latency to fall mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0017285 Success
Aak1tm1b(EUCOMM)Hmgu ICS Indirect Calorimetry / Total food intake HOM 6f:3m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_CAL_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Latency to center entry HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.26264 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Percentage center time HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.11582 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Aggression HOM 9f:9m Fisher Exact Test framework 1.0000 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Number of center entries HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.31705 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Tremor HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb grip strength measurement mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0035460 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Startle response HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 1.1090E-05 Success
Aak1tm1b(EUCOMM)Hmgu ICS Indirect Calorimetry / Total water intake HOM 3f:3m Not processed 1.0000 FAILED - Not enough mutant measurements (3f/3m)
Aak1tm1b(EUCOMM)Hmgu ICS Eye Morphology / Pupil Light Response HOM 7f:8m Fisher Exact Test framework 0.11061 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Limb grasp HOM 9f:9m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Whole arena average speed HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 5.4577E-05 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Center distance travelled HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.23488 Success
Aak1tm1b(EUCOMM)Hmgu ICS Combined SHIRPA and Dysmorphology / Vocalization HOM 9f:9m Fisher Exact Test framework 0.072111 Success
Aak1tm1b(EUCOMM)Hmgu ICS Open Field / Periphery distance travelled HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00037701 Success
Aak1tm1b(EUCOMM)Hmgu ICS Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 9f:9m Mixed Model framework, linear mixed-effects model, equation withWeight 2.8935E-05 Success

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