cardiovascular system

This page introduces cardiovascular related phenotypes present in mouse lines produced by the IMPC. The cardiovascular system refers to the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan.



Current Total Number of Genes Tested: 3301


Approach

In order to identify the function of genes, the consortium uses a series of standardised protocols as described in IMPReSS (International Mouse Phenotyping Resource of Standardised Screens).

Heart and vascular function/physiology are measured through several procedures like echocardiography and electrocardiogram and non-invasive blood pressure. Cardiovascular system morphology is assessed through macroscopic and microscopic measurements, like heart weight, gross pathology and gross morphology in both embryo and adult animals. A complete list of protocols and related phenotypes are presented in the table below. Links to impress are provided for more details on the procedure.



Procedures that can lead to relevant phenotype associations

Young Adult:

Embryo:

Phenotypes distribution

This graph shows genes with a significant effect on at least one cardiovascular system phenotype.




The following diagram represents the various biological system phenotypes associations for genes linked to cardiovascular system phenotypes. The line thickness is correlated with the strength of the association.

Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.

Gene KO effect comparator for cardiovascular system continuous parameters

This tool allows you to visualize continuous parameters used by the consortium to assess cardiovascular phenotypes. The measurement values are corrected to account for batch effects to represent the true genotype effect thus allowing a side by side comparison/visualisation.

Use this interactive graph and table:

  • Drag your mouse pointer on any parameter axis to select a region of interest, while the associated gene/s will be automatically filtered for in the gene table below. You can click on a line to highlight it and filter by procedure from the “Procedures” list. Click on the parameter name to know more about it – you get redirected to the IMPReSS pages.
  • Click on any row in the gene table (space next to the gene name) to highlight the corresponding values in the graph above, or click on the gene name to open the associated gene page. When you select a gene row, the parameter name in the graph will change to orange if genotype is significant.
  • Click “Clear filters” to return to the default view.
  • cardiovascular system IKMC/IMPC related publications